Search Hotels Near Poplar Bluff Regional Medical Center, Poplar Bluff

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12 Dec - 13 Dec
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13 Dec - 14 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Poplar Bluff Regional Medical Center hotels

Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
0.2 km from Poplar Bluff Regional Medical Center
9.4 out of 10, Exceptional, (854)
"Very clean, great check in"
United States
Teresa
The price is Rp1.734.304
Rp1.959.329 total
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Reception
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
1.3 km from Poplar Bluff Regional Medical Center
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is Rp1.520.851
Rp1.702.972 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn Poplar Bluff
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
1.8 km from Poplar Bluff Regional Medical Center
9.2 out of 10, Wonderful, (961)
"Nice room helpful staff. "
United States
Deborah
The price is Rp1.567.377
Rp1.770.491 total
includes taxes & fees
20 Dec - 21 Dec
Drury Inn & Suites Poplar Bluff
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
1 km from Poplar Bluff Regional Medical Center
8.8 out of 10, Excellent, (698)
"Amazing place"
United States
Mladen
The price is Rp1.684.276
Rp1.902.810 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Poplar Bluff by IHG
Blackout curtains, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
2.1 km from Poplar Bluff Regional Medical Center
7.8 out of 10, Good, (1004)
"Love the updated rooms and the vending area."
United States
Kathi
The price is Rp1.267.376
Rp1.336.748 total
includes taxes & fees
13 Dec - 14 Dec
Motel 6 Poplar Bluff, MO
Lobby
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
1.6 km from Poplar Bluff Regional Medical Center
7.8 out of 10, Good, (398)
"Good breakfast selection for the price and clean room. "
United States
Jared
The price is Rp1.513.013
Rp1.709.326 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn Poplar Bluff North
In-room safe, desk, free WiFi, bed sheets
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
1.1 km from Poplar Bluff Regional Medical Center
6.6 out of 10, (622)
"The lady at the front was very nice. "
United States
Travis
The price is Rp949.698
Rp1.072.920 total
includes taxes & fees
11 Jan - 12 Jan 2026
Super 8 by Wyndham Poplar Bluff Missouri
Courtyard
Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
5.6 km from Poplar Bluff Regional Medical Center
8.4 out of 10, Very good, (212)
"Had to "
United States
Brenda
Bullwinkles Rustic Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Poplar Bluff Regional Medical Center Hotel Reviews

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

10/10 Excellent
"Staff was helpful and professional. The rooms were clean and comfortable "
Michael 2-night trip
Posted 1 month ago
Hampton Inn By Hilton Dexter
Lake Wappapello

Lake Wappapello

10/10 Excellent
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."
Dyann 2-night trip
Posted 3 months ago
Lake Wappapello

Hotels near other Poplar Bluff Regional Medical Center attractions

Lake Wappapello State Park

You can take time to visit Lake Wappapello State Park during your travels to Wappapello.
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North Main Street Historic District

You can find out about the history of Poplar Bluff when you stop by North Main Street Historic District. While in this family-friendly area, you can enjoy the restaurants.
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Frequently asked questions

What's the area like around Poplar Bluff Regional Medical Center?
Poplar Bluff Regional Medical Center is located in Poplar Bluff. Travellers like this family-friendly area for its restaurants. You'll find 18 hotels and other accommodations within a few miles for a convenient home base.
Where is the best place to stay near Poplar Bluff Regional Medical Center?
Adjacent to Poplar Bluff Regional Medical Center, Fairfield Inn & Suites by Marriott Poplar Bluff is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. Other good choices within a short distance include Holiday Inn Poplar Bluff by IHG and Hampton Inn Poplar Bluff.
How many hotels will I be able to find close to Poplar Bluff Regional Medical Center?
Expedia has 18 hotels and other accommodation options a few miles from Poplar Bluff Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Poplar Bluff Regional Medical Center, will I receive a refund?
Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to view the best deals available near Poplar Bluff Regional Medical Center.
What can I see and do near Poplar Bluff Regional Medical Center?
You'll want to browse the exhibits at Margaret Harwell Art Museum and Mo-Ark Regional Railroad Museum. You might plan a visit to Black River Coliseum or Ozark Ridge Golf Course while you're in the area. A visit to North Main Street Historic District is worth the trip when you're visiting.