Search Hotels in Grand Isle, Port St. Joe

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Check prices for these dates

Tonight
12 Nov - 13 Nov
Tomorrow
13 Nov - 14 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for Grand Isle hotels

A wooden boardwalk leading to a beach with clear skies.

1. Driftwood Inn

Driftwood Inn
2.0 star property
0.5 km from Grand Isle
9.6 out of 10, Exceptional, (137 reviews)
"Right on the beach"
United States
Jeff
The price is Rp3.243.032
Rp3.632.195 total
includes taxes & fees
29 Nov - 30 Nov
Driftwood Inn
A wooden boardwalk leading to a beach with clear skies.

2. The Blu - A Boutique Motel

The Blu - A Boutique Motel
5.5 km from Grand Isle
10.0 out of 10, Exceptional, (3 reviews)
"Location was great"
United States
Christy
The price is Rp2.840.994
Rp4.173.155 total
includes taxes & fees
15 Nov - 16 Nov
The Blu - A Boutique Motel
A black double door entrance with a black mat, white walls, and two large green planters with flowers.

3. The Port Inn - Port St Joe, an Ascend Collection Hotel

The Port Inn - Port St Joe, an Ascend Collection Hotel
3.5 star property
Downtown Port St. Joe, 17.9 km from Grand Isle
9.0 out of 10, Wonderful, (483 reviews)
"The property is adorable and the staff was amazing. I really could not ask for a better experience."
United States
Elizabeth
The price is Rp2.368.289
Rp2.652.484 total
includes taxes & fees
30 Nov - 1 Dec
The Port Inn - Port St Joe, an Ascend Collection Hotel
A Holiday Inn Express & Suites hotel with a covered entrance, palm trees, and a parking lot.

4. Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
2.5 star property
29.1 km from Grand Isle
8.6 out of 10, Excellent, (539 reviews)
"Great for the price."
United States
Anita
The price is Rp1.643.642
Rp1.776.284 total
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
A breakfast bar with seating, a refrigerator stocked with food, and a sign indicating breakfast service.

5. MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South
2.5 star property
22.1 km from Grand Isle
8.6 out of 10, Excellent, (794 reviews)
"Great location to many attractions great staff and room"
United States
Darryl
The price is Rp1.897.594
Rp2.125.306 total
includes taxes & fees
13 Dec - 14 Dec
MainStay Suites Port Saint Joe South
A hotel room with a large bathtub, a sofa, a small table, a bed, and a large mirror.

6. Comfort Suites

Comfort Suites
2.5 star property
29 km from Grand Isle
8.4 out of 10, Very good, (833 reviews)
"place was clean and safe. Bed was good and breakfast was hot."
United States
Sandra
The price is Rp1.361.875
Rp1.471.778 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Suites
A hotel sign for Candlewood Suites, an IHG hotel, with a parking lot and cars in front.

7. Candlewood Suites Panama City Tyndall AFB by IHG

Candlewood Suites Panama City Tyndall AFB by IHG
2.5 star property
28.6 km from Grand Isle
9.4 out of 10, Exceptional, (109 reviews)
"Clean hotel."
United States
Patricia
The price is Rp2.041.006
Rp2.205.715 total
includes taxes & fees
14 Nov - 15 Nov
Candlewood Suites Panama City Tyndall AFB by IHG
A hotel room with two beds, a nightstand with a lamp, and a beach mural on the wall.

8. Days Inn by Wyndham Panama City/Callaway

Days Inn by Wyndham Panama City/Callaway
2.0 star property
29.4 km from Grand Isle
6.8 out of 10, (576 reviews)
"We found trash in our room. Behind night stand and behind the beds. The pool outside looked horrible."
United States
Marion
The price is Rp1.028.631
Rp1.111.640 total
includes taxes & fees
22 Nov - 23 Nov
Days Inn by Wyndham Panama City/Callaway
A wooden staircase leading to a beach with waves and a sunset in the background.

9. Cape San Blas Inn

Cape San Blas Inn
3.0 star property
27 km from Grand Isle
9.8 out of 10, Exceptional, (82 reviews)
"I loved the back deck with a hot tub to look at the stars, as well as paddleboards, kayaks, and bicycles for use."
United States
Brittany
The price is Rp5.421.309
Rp6.071.903 total
includes taxes & fees
19 Nov - 20 Nov
Cape San Blas Inn
A hotel room with two beds, wooden flooring, and a window with blinds.

10. Extended Stay America Select Suites - Panama City - Callaway

Extended Stay America Select Suites - Panama City - Callaway
2.5 star property
30.1 km from Grand Isle
6.2 out of 10, (550 reviews)
"Clean"
United States
Yeriel
The price is Rp1.153.981
Rp1.247.181 total
includes taxes & fees
7 Dec - 8 Dec
Extended Stay America Select Suites - Panama City - Callaway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Grand Isle

Find the best Grand Isle areas for the activities you enjoy most.
A marina at sunset with boats docked and a wooden pier.
Photo by Russell Hewatt
Open Photo by Russell Hewatt

Downtown Port St. Joe

If you're spending some time in Downtown Port St. Joe, Port Saint Joe City Hall and Constitution Convention Museum State Park are top sights worth seeing.

A white house with a black roof, a white lighthouse with a black top, and a calm lake with purple flowers in the foreground.

Cape Breezes

Cape Breezes might not have many top sights, but T.H. Stone Memorial St. Joseph Peninsula State Park and St. Joseph Peninsula State Park are two attractions nearby that you can check out.

A beach with driftwood formations at sunset.

Gulf Aire

While Gulf Aire may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Saint Joe Beach and Mexico Beach.

A sandy beach with calm waters and a large cloud in the sky.

Waterside Village

While Waterside Village isn't home to many top sights, Mexico Beach Marina and Mexico Beach are some notable places to visit nearby.

A coastal landscape with tall grasses, a palm tree, and a sunset over the water.

Palms

While there might not be top attractions in Palms, you can explore the larger area and discover places like Mexico Beach and Mexico Beach Marina.

Top Grand Isle Hotel Reviews

A breakfast bar with seating, a refrigerator stocked with food, and a sign indicating breakfast service.
MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South
Port St. Joe

10/10 Excellent

The room was quiet and clean. I appriciated having a full size refrigerator with freezer for my blue ice I use in my travel cooler. There wasn't much of a breakfast but that isn't unusual these days. The location was excellent. I would stay here again if ever in Port St. Joe.
United Kingdom
Michael
Reviewed August 29, 2025
MainStay Suites Port Saint Joe South

Frequently Asked Questions

What is Grand Isle like?

Travellers to Mexico Beach's Grand Isle neighbourhood will be sure to enjoy a stay here.

How many hotels are there in Grand Isle?

When you want to put your feet up after a day of exploring the sights in Mexico Beach, you can choose from 11 Expedia hotels and other accommodation options in Grand Isle.

If I need to cancel my hotel reservation in Grand Isle, will I receive a refund?

Yes! The majority of room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might be able to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view the best options available in Grand Isle.

What is there to do around this Mexico Beach neighbourhood?

Mexico Beach Business Center, Mexico Beach and Mexico Beach Marina are just a few of the places to visit in and around Grand Isle. When you're sightseeing around the area, Saint Joe Beach and Windmark Beach are a couple of other sights to visit.