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16 Oct - 17 Oct
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17 Oct - 18 Oct
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16 Oct - 18 Oct
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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
Rp2.452.304
Rp2.783.365 total
includes taxes & fees
1 Nov - 2 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A modern restaurant with a bar area, wooden ceiling, and large windows.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

2. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
Rp3.034.213
Rp3.443.832 total
includes taxes & fees
24 Oct - 25 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

3. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
Rp2.206.374
Rp2.504.235 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A lobby with a reception desk, seating area, and a staircase.
Lobby sitting area
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
Rp1.847.614
Rp2.097.041 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
Rp2.128.882
Rp2.416.249 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
Rp2.726.576
Rp3.094.664 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A round marble table with a magazine, a pair of glasses, and a coffee cup.
A hotel room with two beds, a nightstand with a lamp, and a pair of slippers on the floor.
A living room with a sofa, a coffee table, a hanging light fixture, a framed picture, and a floor lamp.
A cafe with a front desk, a coffee machine, and two chairs outside.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
Rp3.420.472
Rp3.882.235 total
includes taxes & fees
18 Oct - 19 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A hotel room with two beds, a desk, a chair, and a large window with a view.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.
A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
Rp1.766.646
Rp2.005.144 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern living room with sofas, a coffee table, and a dining area.
A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.
A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
Rp2.134.622
Rp2.422.796 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott® Jacksonville Mayport
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A pathway leading to a sunset over a beach with sand and grass.
A modern building entrance with a sign reading "element by Westin".
A modern conference room with a long table, several chairs, and pendant lighting.

10. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Lisa
Rp2.583.072
Rp2.931.787 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Room
A conference room with multiple tables and chairs, large windows with curtains, and a flat-screen TV mounted on the wall.
Terrace/patio

11. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Camoya
Rp2.170.498
Rp2.463.516 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".
A modern hotel with a pool, palm trees, and a clear blue sky.
A modern bar area with seating, a bar counter, and a view of the city through large windows.

12. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
Rp3.210.902
Rp3.644.375 total
includes taxes & fees
18 Oct - 19 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern bar area with a counter, bar stools, and a television screen.
A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
Rp2.127.186
Rp2.414.356 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
An outdoor seating area with round tables and blue chairs, shaded by blue umbrellas with a logo, in front of a building with balconies and palm trees.
A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.
A beachside bar with a long counter, multiple chairs, and a view of the ocean.

14. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
Rp2.881.740
Rp3.270.775 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Jacksonville Beach/Oceanfront
A self-service beverage station with a refrigerated display and a coffee machine.
A modern lounge area with seating, tables, and hanging lights.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.
A snack display in a store with various chips and snacks.

15. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Josephine
Rp1.963.852
Rp2.228.971 total
includes taxes & fees
1 Nov - 2 Nov
Tru By Hilton Jacksonville St Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.
A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.
A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
Rp1.735.502
Rp1.969.794 total
includes taxes & fees
26 Oct - 27 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
A spacious lobby with a reception desk, seating area, and large windows.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.
A bar area with wooden chairs, a round table, and a brick wall.

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Madison
Rp2.113.276
Rp2.356.302 total
includes taxes & fees
29 Oct - 30 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.
A pier extending into the ocean at sunset with birds flying above.
A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.
A golf course with a water hazard and a bridge.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
Rp2.044.932
Rp2.320.998 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express Jacksonville Beach by IHG
An outdoor patio with seating, a fire pit, and string lights.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.

19. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
Rp2.281.714
Rp2.589.746 total
includes taxes & fees
19 Oct - 20 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A hotel room with a dining area, two beds, a TV, and a kitchenette.
A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.
A compact kitchen with dark cabinetry, a built-in refrigerator, a dining table with a chair, and a wall-mounted lamp.
A covered outdoor seating area with stone steps leading up to a table and chairs.

20. Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
9.2 km from Mayo Clinic Florida
United States
Joe
Rp1.883.490
Rp2.137.761 total
includes taxes & fees
25 Oct - 26 Oct
Candlewood Suites Jacksonville - Mayport by IHG
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
609 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
376 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
664 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,005 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,004 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
"What a great stay in Jacksonville! We were there for appointments at Mayo. Check-in very friendly and helpful. The facility was immaculate. Breakfast was awesome! Fresh ground/brewed coffee by the cup. Very good selection. Fresh and appealing. Housekeeping was excellent. They have a free shuttle to Mayo and back every hour which was a tremendous benefit. We enjoyed our stay so much, we almost stayed an extra day!!"
Robert 3-night trip
Posted 2 hours ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

8/10 Good
"Great room! Only complaint was noisy ac motor next to bed."
Susan 1-night trip
Posted 2 hours ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"They were awesome and couldn t ask for better serving."
Tonja 2-night trip
Posted 4 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent
"Nice weekend stay for the price close to the beach. Quiet area."
marcia 2-night trip
Posted 8 hours ago
Holiday Inn Express Jacksonville Beach by IHG
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

8/10 Good
"."
Shaneen 1-night trip
Posted 13 hours ago
TownePlace Suites by Marriott Jacksonville East
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"The number one thing about our stay was the staff. John checked is in and everyone we interacted with was positive and helpful. They were generous with coffee and towels. When a little maintenance was needed, they were two quick to reply, the problem wasn't significant enough and we needed to rest. A wild party interrupted next door to us and I asked when quiet time started and at that time (10pm) the wild noise stopped. The TV was good, the balcony better, and the exercise room more than adequate. We did not eat on property but service is available. Thank you Margaritaville."
Patrick 4-night trip
Posted 1 day ago
Margaritaville Jacksonville Beach

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.