Find hotels in Panacea, FL from Rp1.572.696

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Top 10 Panacea hotels and places to stay

The Panacea Motel

2.0 star property
Panacea
9.0 out of 10, Wonderful, (136)
"A v nice place to stay "
United States
Harry
The Panacea Motel

The Lodge at Wakulla Springs

3.0 star property
Crawfordville
9.4 out of 10, Exceptional, (1001)
"Great stay. Boat tour was enjoyable. Quiet relaxing place"
United States
PATRICIA
The Lodge at Wakulla Springs

Wildwood Inn

3.0 star property
Crawfordville
8.6 out of 10, Excellent, (1002)
"Enjoyed our stay and would definitely stay again!"
United States
Corey
The price is Rp1.911.357
Rp2.197.754 total
includes taxes & fees
21 Dec - 22 Dec
Wildwood Inn

St James Bay Golf & Pickleball Resort

3.5 star property
Carrabelle
9.0 out of 10, Wonderful, (366)
"The facility and amenities were wonderful! Everyone was so friendly and helpful. Our pup enjoyed his stay also. We will be back for sure! "
United States
Amy
The price is Rp2.348.073
Rp2.594.621 total
includes taxes & fees
1 Jan - 2 Jan 2026
St James Bay Golf & Pickleball Resort

Best Western Wakulla Inn & Suites

2.5 star property
Crawfordville
8.8 out of 10, Excellent, (945)
"Great hotel. Very good customer service and very clean"
United States
claudina
The price is Rp1.851.258
Rp2.064.153 total
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Wakulla Inn & Suites

The Moorings Hotel and Marina

2.5 star property
Carrabelle
8.4 out of 10, Very good, (39)
"Hotel was really nice and convenient to everything we wanted to do in the area. Very quiet and peaceful. Bed was a little uncomfortable, but that's a personal preference thing and I won't fault them for that. Really nice staff and easy check in and check out. Would definitely return!"
United States
Cheryl
The price is Rp2.297.524
Rp2.538.764 total
includes taxes & fees
5 Jan - 6 Jan 2026
The Moorings Hotel and Marina

The Old Carrabelle Hotel

2.0 star property
Carrabelle
The price is Rp2.380.664
Rp2.630.634 total
includes taxes & fees
1 Jan - 2 Jan 2026
The Old Carrabelle Hotel

Franklin Inn

2.0 star property
Carrabelle
7.8 out of 10, Good, (453)
"JJ was great great location clean room comfortable bed and good value. "
United States
Crystal
The price is Rp1.423.255
Rp1.572.696 total
includes taxes & fees
7 Dec - 8 Dec
Franklin Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Panacea attractions

Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

Sunset over a lake at Panacea, northern Florida, USA | NONE |

Top Panacea Hotel Reviews

More cheap stays in Panacea

Find out more about Panacea

Top reasons to visit Panacea

  • Stunning Beaches: Panacea boasts beautiful beaches perfect for sunbathing and water activities.
  • Outdoor Adventures: Enjoy a range of activities in nearby national and state parks, ideal for exploration.
  • Family-Friendly Atmosphere: The charming Apalachicola area offers recreational activities suitable for all ages.
  • Vibrant Local Culture: Proximity to Florida State University enriches the area's cultural experiences.
  • Diverse Accommodation: Choose from pet-friendly hotels to quaint guesthouses, catering to every traveller's needs.

Find great hotels near Panacea

Discover a range of delightful accommodation options in Panacea, Florida, perfect for every traveller's needs. From pet-friendly hotels to charming guesthouses, you can enjoy modern amenities including air conditioning, complimentary Wi-Fi, and private pools. Whether you're seeking an adventurous getaway or a relaxing business trip, Panacea offers a welcoming experience for all visitors.

  • Best Western Wakulla Inn & Suites: Ideal for business travellers and adventure seekers, Best Western Wakulla Inn & Suites is a welcoming hotel situated a mere 9.7km from Panacea. This property caters to those in search of a blend of professional amenities and thrilling recreational activities. Guests can indulge in a variety of adventure sports nearby, including biking, sailing, snorkelling, kayaking, and hiking. The hotel aims to provide a comfortable stay while ensuring easy access to local attractions and outdoor experiences.
  • Wildwood Inn: Located 11.3km from Panacea, Wildwood Inn shines as a pet-friendly 3-star hotel suited for both business and adventure travellers. With its warm atmosphere, this inn offers a range of outdoor activities such as sailing, kayaking, and mountain biking. The property is also notable for its pet-friendly policies, allowing pets with certain restrictions. Guests appreciate the opportunity to explore the local scenery while enjoying comfortable accommodations, making it an excellent choice for those who travel with their furry companions.
  • St James Bay Golf & Pickleball Resort: Situated 20.9km from Panacea, this 3.5-star resort is a golfer's paradise, offering an exciting blend of golf-themed activities and pet-friendly amenities. Guests can enjoy a round of golf on-site or engage in various adventure sports, including parasailing, windsurfing, and fishing. The resort's welcoming environment for pets adds an extra layer of appeal for animal lovers. With its focus on both leisure and sport, St James Bay is perfect for those seeking an active holiday experience.

Where to stay in Panacea

Panacea, Florida, offers a delightful blend of beachside relaxation and scenic outdoor adventures. Nearby attractions, such as the charming Apalachicola area, provide a family-friendly atmosphere perfect for recreation. With its proximity to Florida State University and the picturesque Apalachee Parkway, visitors can enjoy both vibrant local culture and tranquil retreats. Whether you seek relaxation or exploration, Panacea and its surrounding locales promise a memorable vacation experience.

  • Alligator Point: Nestled close to Panacea, Alligator Point is a charming village known for its picturesque beaches and serene outdoor experiences. The area attracts visitors predominantly from May to July, offering a tranquil escape for those seeking sun, sand, and spectacular scenery. While here, you can indulge in activities at the local recreational areas, unwind at resorts, or even hit the greens at a nearby golf course. Noteworthy attractions include the pristine beach, the stunning national state park, and lush wetlands, making it a great spot for nature enthusiasts and beach lovers alike.
  • Saint Teresa: Also situated within the vicinity of Panacea, Saint Teresa is a quaint village that provides a delightful mix of beach relaxation and outdoor adventure. This area sees a moderate influx of travellers, especially during the peak months of March and June to July. Visitors flock to Saint Teresa for its beautiful beaches and scenic landscapes, while recreational areas and resorts offer ample opportunities for leisure. Unique attractions such as a nudist beach and a national state park enhance its allure, making it a perfect destination for those seeking both tranquillity and excitement.
  • Ochlockonee Bay: Ochlockonee Bay is a hidden gem located near Panacea, where outdoor enthusiasts can revel in the beauty of nature. With visitor numbers peaking from May to July, this village invites travellers to explore its stunning beaches and scenic river views. The area boasts various recreational opportunities, educational experiences, and local markets, ensuring a well-rounded visit. Highlights include the captivating national state park and the tranquil river, providing a perfect backdrop for kayaking, fishing, or simply enjoying the great outdoors.

Things to do in and around Panacea

Panacea, Florida, is an ideal destination for beach and outdoor enthusiasts, offering stunning scenery and a range of activities. Visitors can enjoy an active getaway with swimming opportunities, a barbeque area, and a delightful beach experience. The area features popular attractions such as a recreational area, resorts, and golf courses, making it perfect for a relaxing beach holiday.

Shopping

For a delightful shopping experience in Panacea, explore local treasures at the Tallahassee Downtown Market, 46.7km away, offering a vibrant public market atmosphere. If you're up for a drive, visit Governor's Square Mall and Woodville Commons, both providing a blend of shopping and entertainment for the whole family.

Recreation

At Woolley Park, immerse yourself in tranquil surroundings perfect for relaxation and rejuvenation. Myron B Hodge City Park offers serene green spaces ideal for leisurely strolls and mindfulness. For sports enthusiasts, St. James Bay Golf Club presents an invigorating outdoor experience just 20.9km away, featuring beautiful landscapes.

Adventure

Explore the Tallahassee-Saint Marks Historic Railroad Trail State Park, located 43.5km from Panacea, for a scenic hiking adventure amidst nature's beauty. Alternatively, enjoy the thrills at Tom Brown Tennis Center, 49.9km away, where you can engage in exciting tennis activities surrounded by vibrant outdoor vibes.

Nightlife

The nightlife in Panacea offers a charming mix of romance and culture. A short drive to Theatre Tallahassee provides an entertaining evening filled with captivating performances, making it a perfect spot for those seeking a vibrant atmosphere and cultural experiences after dark.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Panacea

For a budget-friendly trip to Panacea, Florida, consider visiting during the cheaper months of July and December to January, avoiding the pricier May and September to October. Booking your stay on a Monday can also save you money compared to Fridays. Use Expedia to filter accommodations by budget and preferences, including eco-certifications. Additionally, look for package deals combining flights and activities for further savings. Explore free local attractions and utilise public transport to keep costs down while enjoying your visit.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Panacea are July and December to January, where the prices are slightly lower. This is in comparison to May and September to October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Panacea is Monday. The most expensive day to stay in Panacea is Friday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to refine your preferences, such as your budget, desired location, and the type of accommodation you prefer. For instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are currently available. To find the best prices and offers, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your Panacea hotel reservation with your flights and activities through an Expedia package.

Find the best attractions in Panacea

Panacea is an ideal destination for beach lovers and outdoor enthusiasts, offering stunning scenery and a variety of attractions. Visitors can explore beautiful beaches, the nearby national and state parks, and charming islands. This coastal locale provides a perfect blend of relaxation and adventure, making it a wonderful choice for those seeking a memorable outdoor experience.

  • Alligator Point Beach: Experience the laid-back beach vibes of Alligator Point Beach, where you can enjoy sunbathing, swimming, and beachcombing along its beautiful shores. The tranquil atmosphere makes it perfect for relaxation and soaking in the stunning views of the Gulf of Mexico.
  • Bald Point State Park: Embrace the great outdoors at Bald Point State Park, a haven for adventurers. Explore scenic trails, observe diverse wildlife, and take in breathtaking vistas of marshlands and the coastline. It's an ideal spot for hiking, fishing, and birdwatching.
  • Panacea Springs: Visit Panacea Springs for a delightful urban park experience, perfect for families. Enjoy picnicking, walking trails, and the lush greenery, making it an excellent spot for leisurely afternoons in a charming city setting.

Best time to go to Panacea

The best time to visit Panacea is dependent on what kind of holiday you are seeking. July and August are its hottest month on average. At the time of August, visitor numbers are average and weather is mostly sunny. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.6°F (12.0°C)Light RainMostly SunnyAverageSlightly Low
February57.6°F (14.2°C)Light RainMostly SunnyAverageAverage
March62.4°F (16.9°C)Light RainMostly SunnyAverageAverage
April68.2°F (20.1°C)Light RainMostly SunnyModerately HighAverage
May74.8°F (23.8°C)Light RainMostly SunnyAverageSlightly High
June80.4°F (26.9°C)Moderate RainMostly SunnyModerately HighAverage
July81.7°F (27.6°C)Moderate RainMostly SunnyModerately HighSlightly Low
August81.7°F (27.6°C)Moderate RainMostly SunnyAverageAverage
September78.4°F (25.8°C)Light RainMostly SunnyAverageSlightly High
October71.1°F (21.7°C)Light RainMostly SunnyModerately LowSlightly High
November61.9°F (16.6°C)Light RainMostly SunnyModerately LowAverage
December57.6°F (14.2°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Panacea

Accessing Panacea, Florida, is convenient via Tallahassee International Airport (TLH), situated 41.8km away. Excellent hotel options near TLH include the 3.5-star Hotel Indigo Tallahassee - Collegetown by IHG and the 3-star Residence Inn Tallahassee Universities at the Capitol, both only 6.4km from the airport. Another good choice is the SpringHill Suites Tallahassee Central, located 11.3km away. All these hotels offer easy access to the airport, ensuring a smooth transition for visitors. With various airlines operating at TLH, travellers will find ample choices for their journey to this charming coastal town.

Frequently asked questions

Where is the best place to stay in Panacea?
Expedia customers give high marks to The Panacea Motel. See all available top hotels, or vacation rentals in Panacea.
If I need to cancel my hotel reservation in Panacea, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.
What's the best dog-friendly place to stay in Panacea?
The Panacea Motel is a top dog-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.
How is it to stay in Panacea?
Nature enthusiasts will enjoy exploring Panacea, and many visitors will definitely appreciate the beaches and seafood restaurants. The relaxing and secluded setting also entices those visiting the city. In Panacea, there are 212 hotels and other accommodation options to choose from. Find out more about Panacea.
What are the top places to visit in Panacea?
Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach and Bald Point State Park. Dolphin viewing is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your itinerary are Wilson Beach and Public Beach Access. Take a look at what more there is to see and do in Expedia's Panacea guide.
What's the seasonal weather in Panacea?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. The rainiest months in Panacea are August, July, June and September, with each month seeing an average of 201 mm of rainfall.

Explore a world of travel with Expedia