Search Hotels Near Saint Francis Medical Center, Cape Girardeau

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29 Dec - 30 Dec
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Our top choices for Saint Francis Medical Center hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
0.8 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (1011)
"Great place and staff, very accommodating!"
United States
Megan
The price is Rp1.506.883
Rp1.699.785 total
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
0.5 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is Rp1.771.286
Rp1.998.259 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn Cape Girardeau I 55 East
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
0.5 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is Rp1.523.795
Rp1.719.054 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
0.9 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (1003)
"Awesome stay!"
United States
Breckin
The price is Rp1.506.883
Rp1.699.785 total
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites Cape Girardeau
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
1.5 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (144)
"Clean room great breakfast "
United States
Carl
The price is Rp1.473.560
Rp1.662.382 total
includes taxes & fees
8 Jan - 9 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
0.4 km from Saint Francis Medical Center
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is Rp1.171.983
Rp1.322.185 total
includes taxes & fees
3 Jan - 4 Jan 2026
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
1.6 km from Saint Francis Medical Center
8.2 out of 10, Very good, (886)
"Room was clean and spacious."
United States
George
The price is Rp1.172.150
Rp1.414.448 total
includes taxes & fees
25 Jan - 26 Jan 2026
Candlewood Suites Cape Girardeau by IHG
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
2 km from Saint Francis Medical Center
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is Rp920.975
Rp1.075.866 total
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
0.8 km from Saint Francis Medical Center
9.0 out of 10, Wonderful, (1004)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
United States
Colleen
The price is Rp1.171.983
Rp1.322.185 total
includes taxes & fees
4 Jan - 5 Jan 2026
Pear Tree Inn Cape Girardeau West
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
3.6 km from Saint Francis Medical Center
10.0 out of 10, Exceptional, (19)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is Rp2.516.472
Rp2.838.932 total
includes taxes & fees
30 Dec - 31 Dec
Rockwood Inn
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
4.3 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (469)
"Very nice hotel within walking distance to many good restaurants "
United States
Vicky
The price is Rp2.093.125
Rp2.371.803 total
includes taxes & fees
11 Jan - 12 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
5.7 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (104)
"It was a nice stay"
United States
Douglas
The price is Rp1.496.668
Rp1.703.418 total
includes taxes & fees
7 Jan - 8 Jan 2026
Tru By Hilton Cape Girardeau
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
4.9 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (479)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is Rp1.612.543
Rp1.819.174 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
6.7 km from Saint Francis Medical Center
8.8 out of 10, Excellent, (679)
"Great place "
United States
GUY
The price is Rp1.409.092
Rp1.524.990 total
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
15.3 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is Rp1.389.668
Rp1.469.206 total
includes taxes & fees
30 Dec - 31 Dec
Drury Inn & Suites Jackson MO
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
6.7 km from Saint Francis Medical Center
8.2 out of 10, Very good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is Rp1.336.251
Rp1.446.156 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Jackson-Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
3.8 km from Saint Francis Medical Center
7.2 out of 10, Good, (689)
"The room was clean and nice. The breakfast was really good."
United States
Kalani
The price is Rp990.969
Rp1.117.953 total
includes taxes & fees
8 Jan - 9 Jan 2026
Quality Inn Cape Girardeau North
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
11.4 km from Saint Francis Medical Center
7.6 out of 10, Good, (426)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is Rp1.085.076
Rp1.174.323 total
includes taxes & fees
29 Jan - 30 Jan 2026
Town House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Saint Francis Medical Center Hotel Reviews

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

10/10 Excellent
"They were great "
Alireza 1-night trip
Posted 3 days ago
Tru By Hilton Cape Girardeau

Hotels near other Saint Francis Medical Center attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties
View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park

Riverfront Bridge Park

4.4/5 (74 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Medical Center?
Saint Francis Medical Center is located in Cape Girardeau. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 9 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Saint Francis Medical Center?
Adjacent to Saint Francis Medical Center, Pear Tree Inn Cape Girardeau Near the Medical Center is one of the top choices for your stay based on our traveller data, and this hotel offers free WiFi and LCD TVs. Other good choices within a short distance include Drury Plaza Hotel Cape Girardeau Conference Center and Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.
How many hotels are there close to Saint Francis Medical Center?
Expedia has 9 hotels and other accommodation options within a mile from Saint Francis Medical Center.
If I need to cancel the hotel reservation for my stay near Saint Francis Medical Center, will I receive a refund?
Yes! The majority of hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Saint Francis Medical Center.
What can I see and do near Saint Francis Medical Center?
You might spend a leisurely day outdoors at Fort D Historic Site and Cape Rock Park. Create some family memories at Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.