Search Hotels Near Saint Francis Healthcare System, Cape Girardeau

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Saint Francis Healthcare System hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
3.1 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1011)
"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "
United States
Michael
The price is Rp1.506.883
Rp1.699.785 total
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (104)
"It was a nice stay"
United States
Douglas
The price is Rp1.500.511
Rp1.707.792 total
includes taxes & fees
7 Jan - 8 Jan 2026
Tru By Hilton Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
0.9 km from Saint Francis Healthcare System
7.2 out of 10, Good, (689)
"The room was clean and nice. The breakfast was really good."
United States
Kalani
The price is Rp993.514
Rp1.120.822 total
includes taxes & fees
8 Jan - 9 Jan 2026
Quality Inn Cape Girardeau North
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
2.7 km from Saint Francis Healthcare System
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is Rp920.975
Rp1.075.866 total
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
3.7 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is Rp1.771.286
Rp1.998.259 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn Cape Girardeau I 55 East
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
3.6 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1003)
"Awesome stay!"
United States
Breckin
The price is Rp1.506.883
Rp1.699.785 total
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites Cape Girardeau
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
4.1 km from Saint Francis Healthcare System
10.0 out of 10, Exceptional, (19)
"My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! "
United States
Kim
The price is Rp2.768.150
Rp3.122.861 total
includes taxes & fees
4 Jan - 5 Jan 2026
Rockwood Inn
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
3.6 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is Rp1.527.708
Rp1.723.468 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
5.3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (469)
"Very nice hotel within walking distance to many good restaurants "
United States
Vicky
The price is Rp2.098.500
Rp2.377.893 total
includes taxes & fees
8 Jan - 9 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
4.7 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (145)
"Clean room great breakfast "
United States
Carl
The price is Rp1.473.560
Rp1.662.382 total
includes taxes & fees
8 Jan - 9 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
3.4 km from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is Rp1.171.983
Rp1.322.185 total
includes taxes & fees
5 Jan - 6 Jan 2026
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
5.3 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (479)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is Rp1.612.543
Rp1.819.174 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
4.2 km from Saint Francis Healthcare System
8.8 out of 10, Excellent, (679)
"Great place "
United States
GUY
The price is Rp1.412.710
Rp1.528.906 total
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
4.2 km from Saint Francis Healthcare System
8.2 out of 10, Very good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is Rp1.336.251
Rp1.446.156 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Jackson-Cape Girardeau
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
4.9 km from Saint Francis Healthcare System
8.2 out of 10, Very good, (886)
"Room was clean and spacious."
United States
George
The price is Rp1.175.160
Rp1.418.079 total
includes taxes & fees
25 Jan - 26 Jan 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
12.3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is Rp1.389.668
Rp1.469.206 total
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites Jackson MO
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
9.3 km from Saint Francis Healthcare System
7.6 out of 10, Good, (426)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is Rp1.087.862
Rp1.177.339 total
includes taxes & fees
29 Jan - 30 Jan 2026
Town House Inn
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
3.5 km from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1004)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
United States
Colleen
The price is Rp1.171.983
Rp1.322.185 total
includes taxes & fees
5 Jan - 6 Jan 2026
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Saint Francis Healthcare System Hotel Reviews

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

10/10 Excellent
"They were great "
Alireza 1-night trip
Posted 4 days ago
Tru By Hilton Cape Girardeau

Hotels near other Saint Francis Healthcare System attractions

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Cape Splash Family Aquatic Center

Bring the children to Cape Splash Family Aquatic Center and have a fun-filled day at this theme park in Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Healthcare System?
Saint Francis Healthcare System is located in Cape Girardeau. This family-friendly area is known for its array of dining options. You'll find 60 hotels and other accommodations within a few miles for a convenient home base.
Where is the best place to stay close to Saint Francis Healthcare System?
Quality Inn Cape Girardeau North is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. It's located just a short 0.6 mi (0.9 km) from Saint Francis Healthcare System. Other good options within a few miles include Drury Plaza Hotel Cape Girardeau Conference Center and La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau.
How many hotels are there near Saint Francis Healthcare System?
Expedia has 60 hotels and other accommodation options a few miles from Saint Francis Healthcare System.
If I need to cancel the hotel reservation for my stay near Saint Francis Healthcare System, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to view the best options available near Saint Francis Healthcare System.
What can I see and do near Saint Francis Healthcare System?
You might spend a leisurely day outdoors at Fort D Historic Site and Cape Rock Park. Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center and Lazy L Safari Park are fun stops for the whole family while you're in town. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.