The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious lobby with modern seating, large windows, and a city view.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Diane

Rp2.437.502

Rp2.709.577 total

includes taxes & fees

4 Oct - 5 Oct

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Claudine

Rp2.380.538

Rp2.856.098 total

includes taxes & fees

8 Oct - 9 Oct

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Frank

Rp2.659.337

Rp2.952.977 total

includes taxes & fees

4 Oct - 5 Oct

A patio with wicker chairs and a round table with a fire pit.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

Rp2.761.434

Rp3.064.928 total

includes taxes & fees

4 Oct - 5 Oct

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A hotel lobby with a bar area, seating, and a television.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A snack and beverage display area with various snacks and drinks.

5. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Derrick

Rp1.914.544

Rp2.135.891 total

includes taxes & fees

18 Oct - 19 Oct

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marius

Rp3.638.079

Rp4.133.518 total

includes taxes & fees

18 Oct - 19 Oct

A covered outdoor area with a wooden railing, chairs, and tables.

A traditional room with wooden paneling, a sofa, armchairs, a patterned rug, and stained glass windows.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

A two-story house with a front porch, a central entrance, and a small garden area.

7. Historic Victorian Inn

Cathedral, 1.5 km from Sioux Empire Medical Museum

Jackie

Rp1.914.939

Rp2.392.908 total

includes taxes & fees

6 Oct - 7 Oct

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A modern lobby with seating areas, a large pillar, and a wall mural.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A spacious hallway with a patterned carpet, large windows, and seating areas.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Todd

Rp2.261.432

Rp2.623.334 total

includes taxes & fees

25 Oct - 26 Oct

A buffet with labeled containers of omelets and other dishes.

A snack and beverage display with various brands and products.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

A reception area with a glass door entrance, a reception desk, and a computer station.

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

John

Rp1.877.820

Rp2.095.735 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Rachael

Rp1.959.980

Rp2.453.005 total

includes taxes & fees

25 Oct - 26 Oct

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

11. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

Rp1.878.017

Rp2.095.820 total

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

Rp1.696.274

Rp1.896.449 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a computer, a television, and a couch.

A black leather chair, a floor lamp, and a window with a view of parked cars.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

13. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

Rp1.698.715

Rp1.899.126 total

includes taxes & fees

25 Sept - 26 Sept

An indoor pool area with a slide, seating, and tropical decor.

A lobby with a stone fire feature, seating area, and a reception desk.

A living room with a fireplace, a television, and a dining area with a table and chairs.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

Rp1.105.607

Rp1.248.486 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A building with a sign that reads "Valley Inn" and another sign indicating a motel.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

15. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Darrel

Rp1.456.622

Rp1.633.732 total

includes taxes & fees

20 Oct - 21 Oct

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A two-story house with a steeply pitched roof, a front porch, and a brick entrance.

A dining room with a wooden table, six chairs, and a chandelier.

16. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveller

Rp4.528.445

Rp5.144.993 total

includes taxes & fees

1 Oct - 2 Oct

17. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Rp976.248

Rp1.106.580 total

includes taxes & fees

29 Sept - 30 Sept

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

Two vending machines in a hallway with a sign that reads "VENDORS".

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

18. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

Rp1.407.622

Rp1.579.797 total

includes taxes & fees

27 Sept - 28 Sept

A reception area with a counter, a food mart sign, and a security camera.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A swimming pool with a tiled floor, a poolside table, and chairs.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

19. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Michael

Rp1.029.880

Rp1.165.415 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Kerri

Rp2.253.384

Rp2.507.694 total

includes taxes & fees

18 Oct - 19 Oct

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 331 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,217 reviews	View
Hotel On Phillips	9.6 Exceptional 1,585 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 673 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,005 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Country Inn & Suites by Radisson, Sioux Falls

10/10 Excellent

"The room was clean and the bed was comfortable. Breakfast was very good with a nice selection. There were grapes as one of the fruits offered! We haven’t had that offered before so it was a very nice choice. Sharon who works the kitchen was super helpful and very kind."

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

8/10 Good

"No breakfast, hair dryer didn't work in either room. Toilet leaked all night. Price was not good for someone who isn't using the water park"

Valley Inn

8/10 Good

"The cost is very reasonable; conveniently located"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Historic Victorian Inn

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

10. Holiday Inn Sioux Falls-City Centre by IHG

11. Sheraton Sioux Falls Hotel & Convention Center

12. Country Inn & Suites by Radisson, Sioux Falls

13. The Center Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Valley Inn

16. Historic Twin Tudors Inn

17. Sioux Falls Inn

18. WoodSpring Suites Sioux Falls

19. Ramada by Wyndham Sioux Falls

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Country Inn & Suites by Radisson, Sioux Falls

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Valley Inn

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions