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11 Nov - 12 Nov
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Our top choices for Southampton hotels

A rooftop pool area with lounge chairs and a view of a tall building at night.

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 1.6 km from Southampton
9.2 out of 10, Wonderful, (1,286 reviews)
"Good hotel. Clean and nice staff."
United States
Ariane
The price is Rp2.153.381
Rp2.680.314 total
includes taxes & fees
15 Nov - 16 Nov
The Westin Houston Medical Center/Museum District
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

2. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
4.4 km from Southampton
9.4 out of 10, Exceptional, (1,011 reviews)
"Great stay."
United States
Francisco
The price is Rp2.134.030
Rp2.511.466 total
includes taxes & fees
16 Nov - 17 Nov
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

3. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3 km from Southampton
9.2 out of 10, Wonderful, (2,731 reviews)
"Great place to stay"
United States
Joel
The price is Rp2.250.668
Rp2.647.238 total
includes taxes & fees
15 Nov - 16 Nov
Hyatt Place Houston Medical Center
A hotel lobby with a grand chandelier, a reception desk, and a carpet with the hotel's name.

4. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 2.7 km from Southampton
9.0 out of 10, Wonderful, (3,825 reviews)
"Great hotel definitely would stay again."
United States
Michael
The price is Rp2.655.103
Rp3.116.724 total
includes taxes & fees
22 Nov - 23 Nov
Blossom Hotel Houston, Curio Collection by Hilton
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

5. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 1.5 km from Southampton
8.6 out of 10, Excellent, (2,255 reviews)
"Wonderful place to stay if you are going to the Medical Center."
United States
Cynthia
The price is Rp1.522.189
Rp1.801.945 total
includes taxes & fees
23 Nov - 24 Nov
Hilton Houston Plaza/Medical Center
A hotel entrance with a modern design, a covered walkway, and a car parked outside.

6. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 5.3 km from Southampton
8.8 out of 10, Excellent, (2,443 reviews)
"Great place to stay Would definitely come back"
United States
Bruce
The price is Rp2.332.965
Rp2.729.571 total
includes taxes & fees
24 Nov - 25 Nov
The Royal Sonesta Houston Galleria
A modern living room with a staircase, a sofa set, a glass coffee table, and a flat-screen TV.

7. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby, 2.4 km from Southampton
8.4 out of 10, Very good, (1,976 reviews)
"Was clean and staff was very friendly"
United States
Scott
The price is Rp1.521.853
Rp1.780.567 total
includes taxes & fees
24 Nov - 25 Nov
DoubleTree by Hilton Hotel Houston - Greenway Plaza
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

8. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3 km from Southampton
9.2 out of 10, Wonderful, (1,287 reviews)
"Clean rooms, helpful staff, and great breakfast."
United States
Nikki
The price is Rp2.250.668
Rp2.647.238 total
includes taxes & fees
26 Nov - 27 Nov
Hyatt House Houston Medical Center
A rooftop pool area with lounge chairs, a fire feature, and a neon sign for "RANCH WATER".

9. Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
5.8 km from Southampton
9.2 out of 10, Wonderful, (1,571 reviews)
"Great location and very nice rooms"
United Kingdom
Nicholas
The price is Rp2.367.326
Rp2.790.750 total
includes taxes & fees
24 Nov - 25 Nov
Hyatt Regency Houston/Galleria
A hotel room with a bed, pillows, and a bottle of wine.

10. The Chifley Houston, Tapestry Collection by Hilton

The Chifley Houston, Tapestry Collection by Hilton
4.0 star property
The Galleria, 5.2 km from Southampton
9.2 out of 10, Wonderful, (1,434 reviews)
"Great stay!"
United States
Laci
The price is Rp2.061.328
Rp2.411.753 total
includes taxes & fees
24 Nov - 25 Nov
The Chifley Houston, Tapestry Collection by Hilton
A tall hotel building with a prominent sign at the top.

11. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
Greenway Plaza-Upper Kirby, 1.5 km from Southampton
7.8 out of 10, Good, (1,750 reviews)
"Great stay"
United States
Lorenzo
The price is Rp1.193.874
Rp1.396.834 total
includes taxes & fees
8 Dec - 9 Dec
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
A rooftop pool area with a covered seating area, a pool with a metal railing, and a cityscape view in the background.

12. Holiday Inn Express Houston - Galleria Area by IHG

Holiday Inn Express Houston - Galleria Area by IHG
2.5 star property
The Galleria, 5 km from Southampton
9.4 out of 10, Exceptional, (1,040 reviews)
"The Professionalism of the Staff, clean rooms and the location is not bad. Close to Malls if you're a shopper and all the chain restaurants."
United States
Otis
The price is Rp2.206.370
Rp2.581.453 total
includes taxes & fees
22 Nov - 23 Nov
Holiday Inn Express Houston - Galleria Area by IHG
A modern interior with a vertical garden wall and a sign reading "ESPERANTO".

13. Hotel Ylem

Hotel Ylem
3.5 star property
3.2 km from Southampton
8.2 out of 10, Very good, (1,593 reviews)
"Clean rooms, nice staff. Will definitely again."
United States
Angela
The price is Rp1.235.288
Rp1.535.711 total
includes taxes & fees
25 Nov - 26 Nov
Hotel Ylem
A hotel pool area with a bar, seating, and a view of the building's exterior.

14. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
3.0 star property
2.9 km from Southampton
8.8 out of 10, Excellent, (1,004 reviews)
"The hotel was conveniently located for walking to Rice University and the room was clean and comfortable."
United States
Reagan
The price is Rp1.855.521
Rp2.193.425 total
includes taxes & fees
15 Nov - 16 Nov
Courtyard By Marriott Houston Medical Center Reliant Park
A large indoor swimming pool with multiple lounge areas and a city view.

15. Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
5.8 km from Southampton
9.4 out of 10, Exceptional, (1,897 reviews)
"Delicious breakfast and very clean hotel."
United States
Kalynn
The price is Rp2.802.813
Rp3.315.461 total
includes taxes & fees
24 Nov - 25 Nov
Hilton Americas-Houston
A hotel lobby with a hot tub, a pool, and a dining area.

16. Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 5.4 km from Southampton
9.4 out of 10, Exceptional, (1,582 reviews)
"Comfortable stay, good breakfast."
United States
Pamela
The price is Rp2.079.594
Rp2.433.124 total
includes taxes & fees
15 Nov - 16 Nov
Drury Inn & Suites Houston Near the Galleria
A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

17. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
6 km from Southampton
8.4 out of 10, Very good, (4,719 reviews)
"Great stay"
United States
Hernando
The price is Rp2.059.475
Rp2.426.589 total
includes taxes & fees
25 Nov - 26 Nov
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
A hotel room with a sofa, ottoman, desk, and a bed.

18. Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
5.9 km from Southampton
8.8 out of 10, Excellent, (1,691 reviews)
"Great place to stay"
Australia
Katrina
The price is Rp2.152.115
Rp2.529.911 total
includes taxes & fees
24 Nov - 25 Nov
Hyatt Place Houston/Galleria
A spacious lobby with a central staircase, a reception desk, and a large plant.

19. Embassy Suites by Hilton Houston Downtown Convention Center

Embassy Suites by Hilton Houston Downtown Convention Center
3.5 star property
5.8 km from Southampton
9.2 out of 10, Wonderful, (1,066 reviews)
"fantastic hotel! will come again"
Canada
Robyn
The price is Rp2.597.910
Rp3.039.556 total
includes taxes & fees
29 Nov - 30 Nov
Embassy Suites by Hilton Houston Downtown Convention Center
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

20. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
3.7 km from Southampton
8.8 out of 10, Excellent, (1,010 reviews)
"Great location."
United States
Sandra P
The price is Rp1.604.133
Rp1.876.836 total
includes taxes & fees
2 Dec - 3 Dec
Comfort Suites Houston near Medical Center- NRG Stadium
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Southampton

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.
Hilton Houston Plaza/Medical Center
4.5 star property
8.6
Excellent
2,255 reviews
View
A modern living room with a staircase, a sofa set, a glass coffee table, and a flat-screen TV.
DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
8.4
Very good
1,976 reviews
View
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
Hyatt Place Houston Medical Center
3.0 star property
9.2
Wonderful
2,731 reviews
View
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
Hyatt House Houston Medical Center
3.0 star property
9.2
Wonderful
1,287 reviews
View
A modern building with a sign reading 'INTERCONTINENTAL' and 'SAFINA MEDITERRANEAN'.
InterContinental Houston by IHG
4.0 star property
9.4
Exceptional
1,011 reviews
View

Where to stay in Southampton

Find the best Southampton areas for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top Southampton Hotel Reviews

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
Texas Medical Center

10/10 Excellent

Brilliant location and pool
United Kingdom
Daniel
Reviewed August 2, 2026
Hilton Houston Plaza/Medical Center

Frequently Asked Questions

What is Southampton like?

Travellers will be sure to enjoy their time in Houston's Southampton neighbourhood.

If I need to cancel my hotel reservation in Southampton, will I receive a refund?

Yes, you'll find most room reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view top deals in Southampton.

What can I see and do in this Houston neighbourhood?

A few places to visit in the area around Southampton include Reliant Stadium, Twilight Epiphany Skyspace and Rice Stadium. When you're sightseeing in Houston, Anderson Clarke Center and Main Street Theater - Rice Village are also worth a stop.