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Go beyond your typical stay in Center

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Pool
Pool
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Pet friendly
Pet friendly

Check prices for these dates

Tonight
11 Nov - 12 Nov
Tomorrow
12 Nov - 13 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for Center hotels

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

1. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
Hannibal
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean rooms, comfy beds, nice pool and good variety at breakfast. Couldn’t ask for much more!"
United States
Sarah
The price is Rp1.980.498
Rp2.304.308 total
includes taxes & fees
6 Dec - 7 Dec
Sleep Inn & Suites Hannibal West
A hotel room with a bed, a sofa, a desk, and a lamp.

2. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
Hannibal
7.6 out of 10, Good, (775 reviews)
"Front desk helpful Clean rooms Great breakfast and lady fixing our breakfast was helpful and kept plenty of food ready for all"
United States
Jerry
The price is Rp1.325.203
Rp1.582.807 total
includes taxes & fees
19 Nov - 20 Nov
Comfort Inn & Suites - Hannibal
A hotel room with two beds, a desk, a television, and a large window with curtains.

3. Best Western On The River

Best Western On The River
2.5 star property
Hannibal
8.8 out of 10, Excellent, (1,001 reviews)
"Location was great!"
United States
Rob
The price is Rp1.824.081
Rp2.104.078 total
includes taxes & fees
12 Nov - 13 Nov
Best Western On The River
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

4. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
Hannibal
8.0 out of 10, Very good, (1,007 reviews)
"Our go to hotel for years when we visit Hannibal."
United States
Gayle
The price is Rp1.319.610
Rp1.535.366 total
includes taxes & fees
6 Dec - 7 Dec
Quality Inn & Suites Hannibal West
A park with a pond, picnic tables, and a gazebo.

5. Cannon Dam Cabins

Cannon Dam Cabins
3.0 star property
Perry
9.4 out of 10, Exceptional, (26 reviews)
"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"
United States
Erika
The price is Rp1.854.967
Rp1.973.221 total
includes taxes & fees
12 Nov - 13 Nov
Cannon Dam Cabins
A hotel room with two beds, a nightstand, and a lamp.

6. The Junction Inn

The Junction Inn
2.0 star property
Perry
6.4 out of 10, (48 reviews)
"good beds nice people good if your fishing Mark Twain"
United States
PAUL
The price is Rp1.206.994
Rp1.283.939 total
includes taxes & fees
16 Nov - 17 Nov
The Junction Inn
A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

7. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
Hannibal
7.2 out of 10, Good, (1,002 reviews)
"Clean, safe hotel and friendly staff"
United States
Julie
The price is Rp997.926
Rp1.151.106 total
includes taxes & fees
5 Dec - 6 Dec
Super 8 by Wyndham Hannibal
A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

8. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
Hannibal
7.4 out of 10, Good, (1,000 reviews)
"Excellent place to stay"
United States
Jared
The price is Rp1.047.415
Rp1.208.167 total
includes taxes & fees
16 Nov - 17 Nov
Motel 6 Hannibal, MO
A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.

9. FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City
2.0 star property
Monroe City
8.4 out of 10, Very good, (496 reviews)
"Nice place to stop for a one night stay."
United States
Ron
The price is Rp1.625.580
Rp1.765.379 total
includes taxes & fees
1 Dec - 2 Dec
FairBridge Inn Express, Monroe City
An indoor swimming pool with a tiled ceiling, multiple levels with windows, and seating areas around the pool.

10. Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
Hannibal
6.4 out of 10, (832 reviews)
"Thanks for the hospitality. We enjoyed this stay very clean."
United States
Natasha
The price is Rp936.515
Rp1.087.529 total
includes taxes & fees
1 Dec - 2 Dec
Baymont by Wyndham Hannibal
A hotel room with two beds, a wooden headboard, a nightstand with a phone, and a wall-mounted lamp.

11. Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
Hannibal
7.4 out of 10, Good, (297 reviews)
"Pretty good place to stay at with a great price !!"
United States
Christian
The price is Rp1.011.472
Rp1.166.733 total
includes taxes & fees
14 Nov - 15 Nov
Days Inn by Wyndham Hannibal
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

12. Lighthouse Inn & Suites

Lighthouse Inn & Suites
3.5 star property
Hannibal
8.8 out of 10, Excellent, (47 reviews)
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
United States
Connie
The price is Rp3.049.913
Rp3.518.075 total
includes taxes & fees
12 Nov - 13 Nov
Lighthouse Inn & Suites
A modern building with a red awning, a parking lot, and a sign indicating an entrance.

13. Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
Hannibal
7.4 out of 10, Good, (188 reviews)
"Great price! Nice comfortable clean room"
United States
Debbie
The price is Rp1.040.371
Rp1.208.131 total
includes taxes & fees
1 Dec - 2 Dec
Howard Johnson BY Wyndham Hannibal
A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

14. Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
Hannibal
9.6 out of 10, Exceptional, (205 reviews)
"Very nice room and great view of the river. Very comfortable bed and very nice shower. Walking distance to so many restaurants and shops. We enjoyed our stay very much!"
United States
Christina
The price is Rp2.739.161
Rp3.784.658 total
includes taxes & fees
12 Nov - 13 Nov
Riverside Inn Hannibal
A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

15. Garden House Bed and Breakfast

Garden House Bed and Breakfast
3.0 star property
Hannibal
8.4 out of 10, Very good, (57 reviews)
"Beautiful Queen Ann B&B, was reasonably priced and within walking distance to the river and down town Hannibal attractions."
United States
Debbie
The price is Rp1.926.016
Rp2.221.660 total
includes taxes & fees
12 Nov - 13 Nov
Garden House Bed and Breakfast
A spacious loft with exposed wooden beams, a large clock on the wall, a rustic brick wall, and a cozy seating area with a sofa and a coffee table.

16. Stay Above Main Street Historic Hannibal Loft

Stay Above Main Street Historic Hannibal Loft
3.0 star property
Hannibal
The price is Rp3.829.144
Rp6.328.564 total
includes taxes & fees
16 Nov - 17 Nov
Stay Above Main Street Historic Hannibal Loft
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Center Hotel Reviews

A hotel room with two beds, a desk, a television, and a large window with curtains.
Best Western On The River

Best Western On The River

Best Western On The River
Hannibal

10/10 Excellent

Very nice one night stay here
United Kingdom
Wendy
Reviewed June 30, 2026
Best Western On The River

Frequently Asked Questions

If I need to cancel my hotel reservation in Center, will I receive a refund?

Yes, you'll find most hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Center.

What is staying in Center like?

Travellers to Center will find plenty to explore and enjoy. In Center, there are 4 hotels and other accommodation options to choose from. Find out more about Center.

What should I do while I'm visiting Center?

A favourite place to visit is Mark Twain Lake. You'll also find Mark Twain State Park and Mark Twain Cave in the area. Take a look at what more there is to see and do in Expedia's Center guide.

What's the seasonal weather in Center?

The hottest months are usually July and August, with an average temperature of 23°C, while the coldest months are January and February, with an average of 2°C. Average annual precipitation for Center is 1199 mm.

Where is the best place for a stay in Center?

Quality Inn & Suites Hannibal West, located 15 mi (24.1 km) from the heart of Center, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Best Western On The River and Comfort Inn & Suites - Hannibal. See all available top hotels, or vacation rentals in Center.