The illuminated Gateway Arch at night with a city skyline in the background.

Clayton Hotel Guide - 4 Stars Hotels in Clayton, St. Louis

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Clayton 4 Star Hotels

Our top choices for Clayton 4-star hotels

A buffet with fruits, pastries, and beverages.

1. Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
4.0 star property
Berkeley
8.4 out of 10, Very good, (1,188 reviews)
"Great stay"
United States
Anthony
The price is Rp2.115.239
Rp2.474.576 total
includes taxes & fees
4 Oct - 5 Oct
Renaissance St. Louis Airport Hotel
A lobby with a sofa, two armchairs, a coffee table, and a staircase.

2. Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis
8.6 out of 10, Excellent, (4,316 reviews)
"Great Stay"
United States
Timothy
The price is Rp2.400.792
Rp2.831.230 total
includes taxes & fees
2 Oct - 3 Oct
Hyatt Regency St. Louis at The Arch
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

3. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,122 reviews)
"Great place to stay!"
United States
Zane
The price is Rp2.571.766
Rp3.096.655 total
includes taxes & fees
18 Oct - 19 Oct
21C Museum Hotel St Louis
A cozy lounge area with leather sofas, a fireplace, and a bar counter.

4. The Cheshire

The Cheshire
4.0 star property
Richmond Heights
8.8 out of 10, Excellent, (1,006 reviews)
"Fantastic hotel, clean and nice rooms, great breakfast and location"
United States
Matthew
The price is Rp2.656.984
Rp3.154.851 total
includes taxes & fees
11 Oct - 12 Oct
The Cheshire
A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

5. Live by Loews - St.Louis

Live by Loews - St.Louis
4.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,342 reviews)
"Great hotel"
United States
Frank
The price is Rp2.846.577
Rp3.385.406 total
includes taxes & fees
4 Oct - 5 Oct
Live by Loews - St.Louis
A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.

6. The Westin St. Louis

The Westin St. Louis
4.5 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1,010 reviews)
"Location was perfect for getting around."
United States
Joanne
The price is Rp2.347.620
Rp2.745.048 total
includes taxes & fees
18 Oct - 19 Oct
The Westin St. Louis
A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

7. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
Central West End
9.2 out of 10, Wonderful, (1,012 reviews)
"Loved the location and everything about this place. Will definitely stay again"
United States
Tosha
The price is Rp2.667.547
Rp3.673.592 total
includes taxes & fees
4 Oct - 5 Oct
The Royal Sonesta Chase Park Plaza St. Louis
A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.

8. River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1,804 reviews)
"Would definitely stay here again!"
United States
Ashley
The price is Rp1.739.167
Rp2.284.850 total
includes taxes & fees
15 Oct - 16 Oct
River City Casino & Hotel
A rooftop terrace with outdoor seating, string lights, and a city skyline view.

9. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
4.0 star property
Grand Center
8.8 out of 10, Excellent, (1,164 reviews)
"Great comfortable hotel with easy access and parking. Good location. Would stay again."
Canada
Timothy
The price is Rp2.113.986
Rp2.493.002 total
includes taxes & fees
5 Oct - 6 Oct
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.

10. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,060 reviews)
"Always a great place to stay!"
United States
Melissa
The price is Rp2.672.022
Rp3.419.715 total
includes taxes & fees
12 Oct - 13 Oct
Ameristar Casino Resort and Spa
A multi-story hotel with a prominent 'Marriott' sign, featuring a classic architectural style with a red brick facade and large windows.

11. Marriott St. Louis Grand

Marriott St. Louis Grand
4.0 star property
Downtown St. Louis
8.2 out of 10, Very good, (1,007 reviews)
"Great hotel"
United States
Andrew
The price is Rp2.721.256
Rp3.236.361 total
includes taxes & fees
3 Oct - 4 Oct
Marriott St. Louis Grand
A rooftop restaurant with round tables, chairs, and a view of the city.

12. Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (2,023 reviews)
"Great location, clean rooms, and friendly staff. We will definitely stay again."
United States
Nicole
The price is Rp2.363.017
Rp2.810.413 total
includes taxes & fees
29 Sept - 30 Sept
Moonrise Hotel
A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

13. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
4.0 star property
Brentwood
9.6 out of 10, Exceptional, (1,016 reviews)
"Excellent place to stay. Beautiful hotel, amazing friendly and attentive staff. Would highly recommend!!"
United States
Janell
The price is Rp2.434.629
Rp2.890.473 total
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel St. Louis Brentwood
A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

14. Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis
9.0 out of 10, Wonderful, (1,353 reviews)
"Beautiful place to stay"
United States
Karen
The price is Rp2.040.584
Rp2.426.845 total
includes taxes & fees
11 Oct - 12 Oct
Embassy Suites by Hilton St. Louis Downtown
A modern lounge with a central fire feature, comfortable seating, and large windows offering a city view.

15. Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
4.0 star property
Downtown St. Louis
7.6 out of 10, Good, (1,272 reviews)
"right next to the ballpark, fun upstairs club, great downstairs bar, lots of fun stuff right around ballpark village, would def stay again"
United States
Scott
The price is Rp2.627.802
Rp3.125.219 total
includes taxes & fees
3 Oct - 4 Oct
Hilton St. Louis at the Ballpark
A brick building with a tower, large windows, and a fountain in the garden.

16. Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
Frontenac
8.8 out of 10, Excellent, (1,000 reviews)
"This is one of our favorite hotels to stay at and the staff is top notch!!"
United States
Michael and Julie
The price is Rp2.627.802
Rp3.061.074 total
includes taxes & fees
4 Oct - 5 Oct
Hilton St. Louis Frontenac
A rooftop pool area with multiple lounge chairs and umbrellas, surrounded by a modern building with large windows.

17. Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (781 reviews)
"Staff was outstanding. Location and room ideal."
United States
Steven
The price is Rp2.723.941
Rp3.207.114 total
includes taxes & fees
11 Oct - 12 Oct
Le Méridien St. Louis Clayton
A modern dining area with round tables, orange chairs, and a decorative wall with pottery.

18. Marriott St. Louis Airport

Marriott St. Louis Airport
4.0 star property
Edmundson
8.0 out of 10, Very good, (1,001 reviews)
"This place was pretty close to the airport so it was good for a layover. They had nice dining options right there in the hotel."
United States
Chris
The price is Rp2.663.071
Rp3.178.055 total
includes taxes & fees
2 Oct - 3 Oct
Marriott St. Louis Airport
A bar area with a central bar, multiple stools, and a chandelier.

19. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1,377 reviews)
"Great place"
United States
Carol
The price is Rp2.255.778
Rp2.682.776 total
includes taxes & fees
25 Oct - 26 Oct
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
A spacious lobby with high arched ceilings, ornate columns, and a central fountain.

20. St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
4.0 star property
Downtown West
8.8 out of 10, Excellent, (1,011 reviews)
"Such a fun hotel. Fun for all age groups We will be back for sure"
United States
Mirjana
The price is Rp3.449.908
Rp4.102.941 total
includes taxes & fees
4 Oct - 5 Oct
St. Louis Union Station Hotel, Curio Collection by Hilton
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Clayton.
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

999 North Second Street St. Louis MO
The price is Rp6.713.625 per night from 4 Oct to 5 Oct
Rp6.713.625
Rp7.850.107 total
4 Oct - 5 Oct
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Still don't see what you're looking for?
See all properties in Clayton.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Clayton Hotel Reviews

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

10/10 Excellent
"Great place to stay"
David 3-night trip
Posted 2 hours ago
Hyatt Regency St. Louis at The Arch

Frequently asked questions

What are the best 4-star hotels in Clayton?
Le Méridien St. Louis Clayton is a 4-star hotel in Clayton that's popular among Expedia guests. A pillow top mattress and windsurfing are a couple of its amenities. Travellers also love The Cheshire. From designer toiletries to concierge services, it comes with conveniences that cater to every aspect of your relaxation and enjoyment.
How much does it cost to stay in a 4-star hotel in Clayton?
Expedia can help you easily locate the perfect 4-star hotel for your getaway in Clayton. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fantastic deals in a couple of clicks.

  • Search for the lowest price from Rp7.850.107

What's the difference between 5-star and 4-star hotels in Clayton?
If you choose to spend your holiday at a 4-star hotel in Clayton, you'll usually find lots of conveniences to keep you relaxed, such as a gym, pool and restaurant. You can look forward to top-quality service and upmarket surroundings. Pick a 5-star hotel and you'll get a few more perks — think around-the-clock concierge, on-site spas and indulgent turndown services. You're likely to get additional amenities and first-class services at a 5-star retreat, though both are superb options for luxury guests.

Explore a world of travel with Expedia