Photo by Serendipity Trip

Southeastern Indiana Hotel Guide - 4 Stars Hotels in Southeastern Indiana, United States of America

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeastern Indiana 4 Star Hotels

Tonight
22 Dec - 23 Dec
Tomorrow
23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Southeastern Indiana 4-star hotels

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3897)
"Great place to stay! "
United States
Rochelle
The price is Rp2.232.775
Rp2.627.083 total
includes taxes & fees
27 Dec - 28 Dec
Galt House Hotel Trademark Collection by Wyndham
3 bars/lounges, cocktail bar, lobby lounge
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1743)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is Rp2.800.600
Rp3.295.228 total
includes taxes & fees
1 Jan - 2 Jan 2026
Omni Louisville Hotel
Reception
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1119)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is Rp1.909.165
Rp2.246.323 total
includes taxes & fees
29 Dec - 30 Dec
Embassy Suites Louisville Downtown
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1155)
"Staff and breakfast was exceptional! "
United States
Alicia
The Brown Hotel
Terrace/patio
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1019)
"Great location and accommodations."
United States
Steve
The price is Rp2.127.250
Rp2.502.923 total
includes taxes & fees
28 Dec - 29 Dec
Hotel Genevieve part of JdV by Hyatt
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1004)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is Rp2.328.250
Rp2.823.380 total
includes taxes & fees
1 Jan - 2 Jan 2026
21c Museum Hotel Louisville
Lobby
Hyatt Regency Louisville

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1002)
"Enjoyed our stay "
United States
Jedediah
The price is Rp2.127.250
Rp2.502.922 total
includes taxes & fees
27 Dec - 28 Dec
Hyatt Regency Louisville
Lobby
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1005)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is Rp2.427.075
Rp2.855.696 total
includes taxes & fees
29 Dec - 30 Dec
The Grady
Exterior
Louisville Marriott Downtown

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1001)
"Very nice hotel. Great stay!"
United States
Brad
The price is Rp2.808.975
Rp3.305.041 total
includes taxes & fees
18 Jan - 19 Jan 2026
Louisville Marriott Downtown
Terrace/patio
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is Rp2.933.428
Rp3.451.472 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Distil, Autograph Collection
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (55)
"Lovely hotel in downtown Louisville. Well appointed room, comfy bed and outstanding dining. "
United States
Michelle
The price is Rp2.819.695
Rp3.317.654 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Exterior
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1001)
"Excellent location and a great lobby bar with a top notch bourbon selection. "
United States
vincent
The price is Rp2.141.990
Rp2.520.265 total
includes taxes & fees
25 Dec - 26 Dec
Seelbach Hilton Louisville Downtown
Lounge
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is Rp1.976.332
Rp3.168.806 total
includes taxes & fees
5 Jan - 6 Jan 2026
Stellar Suites
Property entrance
The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (648)
"Have stayed here once before. Accommodations are wonderful and the sit down breakfast is lovely. Highly recommend this beautiful property."
United States
Kathy
The price is Rp1.487.735
Rp1.681.198 total
includes taxes & fees
25 Dec - 26 Dec
The Pepin Mansion Historic B&B
Seasonal outdoor pool
CozySuites at Nulu

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
8.2 out of 10, Very good, (26)
"The unit was clean, all communications were timely, the property has all the amenities, and NULU is very walkable. A perfect stay! My only regret is that I wasn't able to extend the stay. Highly recommended if you're in the Louisville area "
United States
William
The price is Rp1.002.488
Rp3.107.795 total
includes taxes & fees
20 Jan - 21 Jan 2026
CozySuites at Nulu
Exterior
stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (43)
"Excellent stay. One of my favorite hotels in the area. They never disappoint "
United States
Julia
The price is Rp2.495.750
Rp2.820.198 total
includes taxes & fees
23 Dec - 24 Dec
stayAPT Suites Louisville North-Clarksville
32-inch Smart TV with cable channels
The Reserve on Main

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
The price is Rp2.763.750
Rp4.045.460 total
includes taxes & fees
28 Dec - 29 Dec
The Reserve on Main
Family House, Multiple Beds | Private kitchen | Fridge, microwave, oven, stovetop
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Exterior
TWO Stunning Nulu CozySuites

TWO Stunning Nulu CozySuites

TWO Stunning Nulu CozySuites
4.0 star property
Downtown Louisville
TWO Stunning Nulu CozySuites
Free daily full breakfast
Hawthorn Suites by Wyndham Louisville North

Hawthorn Suites by Wyndham Louisville North

Hawthorn Suites by Wyndham Louisville North
4.5 star property
Jeffersonville
7.4 out of 10, Good, (944)
"I would say that the hotel is in pretty good shape. The rooms are very nice. The parking lot however had a ton of people just hanging out. It made it a bit uncomfortable"
United States
alexis
Hawthorn Suites by Wyndham Louisville North
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southeastern Indiana

Explore lots to see and do in Southeastern Indiana—live music, sports teams and sights from Deam Lake State Recreation Area to Huber’s Orchard, Winery & Vineyards.

See all hotels in Southeastern Indiana
Bathe in the forest...find this on the roof of the outdoor shower house down the hill from the guest house.
Photo by Serendipity Trip
Open Photo by Serendipity Trip

Top Southeastern Indiana Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Southeastern Indiana?
You'll find an array of 4-star hotels in Southeastern Indiana, including in Louisville. Galt House Hotel Trademark Collection by Wyndham is a customer favourite in this destination that comes with beauty services and massage services. Another escape that scores high marks from travellers is Hyatt Regency Louisville. Designer toiletries and a swimming pool help make it their number one choice.
How much does it cost to stay in a 4-star hotel in Southeastern Indiana?
To lock in a 4-star hotel in Southeastern Indiana that fits your budget, make use of Expedia's filter tool. Browse what's available during your holiday dates and use our pricing filter to set your limit. You can also list your results by the most economical stay first.

  • Search for the lowest price from Rp1.681.198

What's the difference between 5-star and 4-star hotels in Southeastern Indiana?
Offering a welcoming traveller experience and upmarket surroundings, 4-star hotels are a fabulous option for your Southeastern Indiana trip. These kinds of accommodation generally come with lots of handy amenities that make it easy to kick back and relax — think pillowtop mattresses, gyms and pools. Or live in the lap of luxury at a 5-star hotel designed to indulge you in high-end perks and amenities. Round-the-clock concierge service, premium toiletries and gourmet dining are typically featured at these plush retreats.