Defiance Hotel Guide - 5 Stars Hotels in Defiance, St. Louis

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Check availability on Defiance 5 Star Hotels

Tonight
8 May - 9 May
Tomorrow
9 May - 10 May
This weekend
8 May - 10 May
Next weekend
15 May - 17 May
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Defiance.
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO
The price is Rp2.759.414 per night from 25 May to 26 May
Rp2.759.414
Rp3.512.494 total
25 May - 26 May
includes taxes & fees
8.6/10 Excellent! (1,006 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

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A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Defiance?
The amount you pay for a 5-star hotel in Defiance depends on things such as when you plan to travel and the length of your getaway. A top tip for scoring an awesome deal? Use our pricing filters to check out all of the available hotels for your preferred dates.

  • Search for the lowest price per night from Rp2.513.595

What makes a hotel 5 stars in Defiance?
From gourmet restaurants and all-day fitness centres to pools and dreamy bedding, the 5-star experience in Defiance is all about comfort and indulgence. But it requires more than just upscale conveniences to earn a 5-star rating. Accommodation also have to provide superb guest services like in-room beauty treatments, on-site laundry and 24/7 room service.
Are there any 5-star all-inclusive resorts in Defiance?
Our handy filters are the best way to narrow down what you're looking for. Select "5-star" and "All inclusive" to see the most upscale properties in Defiance where your room, meals, entertainment and activities are included in the price. At these getaways, your holiday is pure leisure from the moment you put down your suitcase.