A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Defiance Hotel Guide - 5 Stars Hotels in Defiance, St. Louis

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6 Nov - 8 Nov
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13 Nov - 15 Nov
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Defiance.
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO
The price is Rp2.889.003 per night from 16 Nov to 17 Nov
Rp2.889.003
Rp3.677.450 total
16 Nov - 17 Nov
includes taxes & fees
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

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A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Defiance?
The amount you pay for a 5-star hotel in Defiance depends on things such as when you plan to travel and the length of your getaway. A top tip for scoring an awesome deal? Use our pricing filters to check out all of the available hotels for your preferred dates.

  • Search for the lowest price per night from Rp2.719.445

What makes a hotel 5 stars in Defiance?
From gourmet restaurants and all-day fitness centres to pools and dreamy bedding, the 5-star experience in Defiance is all about comfort and indulgence. But it requires more than just upscale conveniences to earn a 5-star rating. Accommodation also have to provide superb guest services like in-room beauty treatments, on-site laundry and 24/7 room service.
Are there any 5-star all-inclusive resorts in Defiance?
Our handy filters are the best way to narrow down what you're looking for. Select "5-star" and "All inclusive" to see the most upscale properties in Defiance where your room, meals, entertainment and activities are included in the price. At these getaways, your holiday is pure leisure from the moment you put down your suitcase.