Photo by Alice Burghart

Search Gay-Friendly Hotels in Cape Girardeau

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Cape Girardeau Gay-Friendly Hotels

Our top choices for Cape Girardeau LGBT-friendly hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is Rp1.497.974
Rp1.689.735 total
includes taxes & fees
18 Dec - 19 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1002)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is Rp1.165.054
Rp1.314.368 total
includes taxes & fees
19 Dec - 20 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is Rp1.930.936
Rp2.188.021 total
includes taxes & fees
23 Dec - 24 Dec
Courtyard by Marriott Cape Girardeau Downtown

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is Rp1.581.370
Rp1.784.008 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1003)
"Very friendly staff and great breakfast"
United States
Ray
The price is Rp1.497.974
Rp1.689.735 total
includes taxes & fees
19 Dec - 20 Dec
Drury Inn & Suites Cape Girardeau

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (782)
"Excellent stay"
United States
Christina
The price is Rp1.651.283
Rp1.862.879 total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Cape Girardeau I 55 East

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very good, (881)
"Clean room, low noise and very comfortable!"
United States
Richard
The price is Rp1.165.220
Rp1.406.084 total
includes taxes & fees
11 Jan - 12 Jan 2026
Candlewood Suites Cape Girardeau by IHG

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Great stay"
United States
Heather
The price is Rp1.165.054
Rp1.314.368 total
includes taxes & fees
21 Dec - 22 Dec
Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is Rp1.381.452
Rp1.460.520 total
includes taxes & fees
15 Dec - 16 Dec
Drury Inn & Suites Jackson MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Cape Girardeau Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

How do I find an LGBTQ-friendly hotel in Cape Girardeau?
Consider this your open invitation to pack your bags and find gay-friendly hotels in Cape Girardeau on Expedia. The restaurants is something travellers enjoy about this welcoming area.
What's the best LGBTQ-friendly hotel in Cape Girardeau?
Pear Tree Inn Cape Girardeau Near the Medical Center is a top LGBTQ-friendly hotel, and features free Wi-Fi and LCD TVs. Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are two other good choices for your holiday.
How many gay-friendly accommodation options are there in Cape Girardeau?
There are currently 8 LGBTQ-friendly accommodation options in Cape Girardeau.
What are the top places to visit in Cape Girardeau?
During your trip, get out and enjoy everything Cape Girardeau has to offer. You and your travelling companions may want to visit Isle Casino Cape Girardeau, Show Me Center and Cape Splash Family Aquatic Center. While you're here, create some great memories of your trip with stops at Hunter Valley Winery, Trail of Tears State Park and Shawnee National Forest.
What is a gay-friendly hotel in Cape Girardeau?
LGBTQ-friendly hotels, also known as gay-friendly hotels, welcome all travellers who identify as LGBTQIA+. You'll find a selection of LGBTQ-friendly accommodation options on our site. In Cape Girardeau, these hotels will provide lesbian, gay, bisexual and transgender adventurers with the information needed to design the trip of a lifetime.
What can I expect from a gay-friendly hotel in Cape Girardeau?
Stay at a gay-friendly hotel in Cape Girardeau and you won't have to hide or your sexuality or your gender identity when you check in. Many of our LGBTQ-friendly accommodation options offer community-specific packages, exclusive tours and opportunities for social interaction.