Photo by Abbie Moon

Find the best Cape Girardeau County Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Cape Girardeau County Accommodation: Most Popular Cities to Stay

HotelsHotels

Cape Girardeau

Cape Girardeau

Check prices for these dates

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Hotels Cape Girardeau County

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1000)
"Great place and staff, very accommodating!"
United States
Megan
The price is Rp1.498.154
Rp1.689.938 total
includes taxes & fees
11 Dec - 12 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby sitting area
The Riverview

The Riverview

4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (464)
"Place was nice and safe"
United States
ryan
The price is Rp1.603.202
Rp1.808.636 total
includes taxes & fees
7 Dec - 8 Dec
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (659)
"Great place "
United States
GUY
The price is Rp1.301.874
Rp1.408.954 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is Rp1.381.618
Rp1.460.696 total
includes taxes & fees
8 Dec - 9 Dec
Drury Inn & Suites Jackson MO
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1002)
"Great stay"
United States
Heather
The price is Rp1.165.194
Rp1.314.526 total
includes taxes & fees
11 Dec - 12 Dec
Pear Tree Inn Cape Girardeau West
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (876)
"Clean room, low noise and very comfortable!"
United States
Richard
The price is Rp1.165.360
Rp1.406.253 total
includes taxes & fees
14 Dec - 15 Dec
Candlewood Suites Cape Girardeau by IHG
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is Rp1.165.194
Rp1.314.526 total
includes taxes & fees
11 Dec - 12 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (99)
"It was a nice stay"
United States
Douglas
The price is Rp1.451.706
Rp1.652.148 total
includes taxes & fees
28 Dec - 29 Dec
Tru By Hilton Cape Girardeau
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"I do love this hotel chain. Another great visit!"
United States
Mark
The price is Rp1.498.154
Rp1.689.938 total
includes taxes & fees
11 Dec - 12 Dec
Drury Inn & Suites Cape Girardeau
Lobby
Quality Inn

Quality Inn

2.5 star property
Cape Girardeau
7.2 out of 10, Good, (680)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is Rp1.003.208
Rp1.131.759 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is Rp1.581.560
Rp1.784.221 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (781)
"Excellent stay"
United States
Christina
The price is Rp1.651.482
Rp1.863.244 total
includes taxes & fees
27 Dec - 28 Dec
Hampton Inn Cape Girardeau I 55 East
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is Rp1.931.168
Rp2.188.284 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (139)
"Nice hotel, clean and comfortable "
United States
Laura
The price is Rp1.465.024
Rp1.652.752 total
includes taxes & fees
14 Dec - 15 Dec
Fairfield Inn & Suites by Marriott Cape Girardeau
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

2.5 star property
Jackson
7.6 out of 10, Good, (422)
"Room was clean and had a refrigerator and microwave for use if needed."
United States
Sherry
The price is Rp1.168.690
Rp1.264.915 total
includes taxes & fees
7 Dec - 8 Dec
Town House Inn
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is Rp915.640
Rp1.069.634 total
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 star property
Jackson
8.2 out of 10, Very good, (739)
"Dirty "
United States
Jon
The price is Rp1.328.510
Rp1.437.780 total
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites Jackson-Cape Girardeau
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is Rp2.501.861
Rp2.822.335 total
includes taxes & fees
14 Dec - 15 Dec
Rockwood Inn
Exterior
La Quinta Inn & Suites by Wyndham Jackson/cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/cape Girardeau

2.0 star property
Jackson
9.4 out of 10, Exceptional, (3)
"Nice place "
United States
jermaine
La Quinta Inn & Suites by Wyndham Jackson/cape Girardeau
House (1 Bedroom) | Interior
Private Getaway on 270 Acres w/ Lake: Swim & Canoe

Private Getaway on 270 Acres w/ Lake: Swim & Canoe

2.0 star property
Advance
Private Getaway on 270 Acres w/ Lake: Swim & Canoe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Great weekend hotel deals in Cape Girardeau County, MO

Showing deals for:19 Dec - 21 Dec

Image gallery for The Riverview

Lobby sitting area

The Riverview

4.0 star property
Cape Girardeau
9.4/10Exceptional (464 reviews)
10% off
Price is Rp3.176.438
Rp7.166.933 total
includes taxes & fees
The Riverview
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Cape Girardeau County Hotel Reviews

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

10/10 Excellent
"Clean"
Rosa 1-night trip
Posted 5 days ago
Holiday Inn Express & Suites Perryville by IHG
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

10/10 Excellent
"Excellent service and Mia was outstanding. "
Michael 1-night trip
Posted 8 days ago
Tru By Hilton Cape Girardeau

Explore a world of travel with Expedia