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13 Dec - 14 Dec
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14 Dec - 15 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Grand Isle hotels

Sun-loungers, beach towels, rowing, fishing
Cape San Blas Inn

Cape San Blas Inn

Cape San Blas Inn
3.0 star property
27 km from Grand Isle
9.8 out of 10, Exceptional, (79)
"Great host excellent location we will be back"
United States
Tonianne
Cape San Blas Inn
Aerial view
Cape Cottages by Panhandle Getaways

Cape Cottages by Panhandle Getaways

Cape Cottages by Panhandle Getaways
3.5 star property
22.8 km from Grand Isle
10.0 out of 10, Exceptional, (4)
"Brand new, quaint spot with really comfortable beds. "
United States
Anonymous traveller
The price is Rp2.372.055
Rp8.995.497 total
includes taxes & fees
14 Dec - 15 Dec
Cape Cottages by Panhandle Getaways
Exterior
The Port Inn and Cottages, an Ascend Collection Hotel

The Port Inn and Cottages, an Ascend Collection Hotel

The Port Inn and Cottages, an Ascend Collection Hotel
3.5 star property
Downtown Port St. Joe, 17.9 km from Grand Isle
9.0 out of 10, Wonderful, (403)
"Great staff, clean and comfortable room "
United States
Karen
The price is Rp1.970.269
Rp2.206.701 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Port Inn and Cottages, an Ascend Collection Hotel
Exterior
Candlewood Suites Panama City Tyndall AFB by IHG

Candlewood Suites Panama City Tyndall AFB by IHG

Candlewood Suites Panama City Tyndall AFB by IHG
2.5 star property
28.7 km from Grand Isle
9.6 out of 10, Exceptional, (33)
"The room was great, the staff was friendly and helpful. "
United States
Robert
The price is Rp1.681.246
Rp1.816.922 total
includes taxes & fees
15 Dec - 16 Dec
Candlewood Suites Panama City Tyndall AFB by IHG
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Comfort Suites

Comfort Suites

Comfort Suites
2.5 star property
29 km from Grand Isle
8.6 out of 10, Excellent, (714)
"Convenient location & comfortable rooms . "
United States
Heidi
The price is Rp1.403.285
Rp1.516.530 total
includes taxes & fees
1 Jan - 2 Jan 2026
Comfort Suites
Free daily continental breakfast
MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South
2.5 star property
22.1 km from Grand Isle
8.6 out of 10, Excellent, (694)
"Room was clean, kitchen very clean, hotel staff was very friendly "
United States
Donna
The price is Rp1.828.523
Rp2.047.946 total
includes taxes & fees
21 Dec - 22 Dec
MainStay Suites Port Saint Joe South
Exterior
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
2.5 star property
29.1 km from Grand Isle
8.4 out of 10, Very good, (445)
"We enjoyed our stay."
United States
Lisa
The price is Rp1.581.370
Rp1.708.987 total
includes taxes & fees
16 Dec - 17 Dec
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
Laptop workspace, iron/ironing board, free cots/infant beds, free WiFi
Days Inn by Wyndham Panama City/Callaway

Days Inn by Wyndham Panama City/Callaway

Days Inn by Wyndham Panama City/Callaway
2.0 star property
29.4 km from Grand Isle
6.8 out of 10, (476)
"Room was clean and the staff was friendly and helpful."
United States
Billie
The price is Rp919.692
Rp993.911 total
includes taxes & fees
27 Dec - 28 Dec
Days Inn by Wyndham Panama City/Callaway
Desk, laptop workspace, iron/ironing board, free WiFi
Extended Stay America Select Suites - Panama City - Callaway

Extended Stay America Select Suites - Panama City - Callaway

Extended Stay America Select Suites - Panama City - Callaway
2.5 star property
30.1 km from Grand Isle
6.2 out of 10, (494)
"great stay"
United States
Victor
The price is Rp1.063.530
Rp1.167.167 total
includes taxes & fees
24 Dec - 25 Dec
Extended Stay America Select Suites - Panama City - Callaway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Grand Isle

Find the best Grand Isle areas for the activities you enjoy most.

Downtown Port St. Joe

If you're spending some time in Downtown Port St. Joe, Port Saint Joe City Hall and Port St. Joe Marina are top sights worth seeing.

Cape Breezes

Cape Breezes might not have many top sights, but T.H. Stone Memorial St. Joseph Peninsula State Park and St. Joseph Peninsula State Park are two attractions nearby that you can check out.

Gulf Aire

While Gulf Aire may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Saint Joe Beach and Mexico Beach.

Waterside Village

While Waterside Village isn't home to many top sights, Mexico Beach Marina and Mexico Beach are some notable places to visit nearby.

Palms

While there might not be top attractions in Palms, you can explore the larger area and discover places like Mexico Beach and Mexico Beach Marina.

Top Grand Isle Hotel Reviews

Candlewood Suites Panama City Tyndall AFB by IHG

Candlewood Suites Panama City Tyndall AFB by IHG

10/10 Excellent
"Everything I was so amazed at how much I got accomplished w all the stuff provided and was able to make my thanksgiving dinner for family we were visiting and also washing was such a blessing also I will definitely be using I all again "
Tanya 5-night trip
Posted 12 days ago
Candlewood Suites Panama City Tyndall AFB by IHG
Cape Cottages by Panhandle Getaways

Cape Cottages by Panhandle Getaways

10/10 Excellent
"Very relaxed and clean"
Rohit 2-night trip
Posted 2 months ago
Cape Cottages by Panhandle Getaways

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Frequently asked questions

What is Grand Isle like?
Travellers to Mexico Beach's Grand Isle neighbourhood will be sure to enjoy a stay here.
How many hotels are there in Grand Isle?
Expedia has 7 Grand Isle hotels and other accommodation options, and one might make a good home base for venturing out into the greater Mexico Beach area.
If I need to cancel my hotel reservation in Grand Isle, will I receive a refund?
Yes! The majority of room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might be able to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view the best options available in Grand Isle.
What is there to do around this Mexico Beach neighbourhood?
Mexico Beach Business Center, Mexico Beach and Mexico Beach Marina are just a few of the places to visit in and around Grand Isle. When you're sightseeing around the area, Saint Joe Beach and Round Timber Island are a couple of other sights to visit.