Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Southwest Illinois hotels

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

1. Best Western U. S. Inn

Nashville

Steven

Rp2.361.878 total

includes taxes & fees

12 Nov - 13 Nov

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

2. Best Western Plus Centralia Hotel & Suites

Centralia

Jeremy

Rp2.811.350 total

includes taxes & fees

12 Nov - 13 Nov

A buffet with various food items, including omelets and other dishes, arranged on a counter with a patterned tile backsplash.

3. Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

Jo Ann

Rp1.763.977 total

includes taxes & fees

15 Nov - 16 Nov

An indoor swimming pool area with multiple lanes, lounge chairs, and a small seating area.

4. Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

Karissa

Rp2.136.517 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a reception desk, seating area, and a large screen TV.

5. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

Rp2.416.515 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Paul

Rp2.221.052 total

includes taxes & fees

6 Dec - 7 Dec

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

7. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

Rp1.479.379 total

includes taxes & fees

22 Nov - 23 Nov

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

8. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Tammi

Rp2.599.483 total

includes taxes & fees

19 Nov - 20 Nov

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

9. Hampton Inn O'Fallon

O'Fallon

paul

Rp2.386.012 total

includes taxes & fees

22 Nov - 23 Nov

A breakfast buffet with various pastries, a bowl of oranges, and a waffle batter dispenser.

10. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

Rp1.499.424 total

includes taxes & fees

15 Nov - 16 Nov

A restaurant with multiple tables and booths, large windows, and a modern interior design.

11. The Principal Hotel

Columbia

Michael

Rp1.966.435 total

includes taxes & fees

12 Nov - 13 Nov

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

12. Best Western Plus MidAmerica Hotel

Mascoutah

Charles

Rp2.074.092 total

includes taxes & fees

15 Nov - 16 Nov

A hotel with a covered entrance, stone pillars, and a modern design.

13. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

Rp2.180.960 total

includes taxes & fees

11 Dec - 12 Dec

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a dresser, and a television.

14. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Mei

Rp2.260.941 total

includes taxes & fees

22 Nov - 23 Nov

A modern living room with a fireplace, blue sofa, red chairs, and a flat-screen TV mounted on a textured wall.

15. Comfort Inn & Suites Greenville I-70

Greenville

Melissa

Rp1.999.644 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio with tables and chairs, a brick building, and a parking lot in the background.

16. Fairfield Inn & Suites by Marriott O'Fallon, IL

O'Fallon

Mohamad

Rp2.877.777 total

includes taxes & fees

29 Nov - 30 Nov

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.

17. Walker's Bluff Casino Resort

Carterville

Ron

Rp3.426.723 total

includes taxes & fees

15 Nov - 16 Nov

A statue of a Native American figure with a horse, a Route 66 sign, a map, and a clock on the wall.

18. Country Hearth Inn & Suites Edwardsville St. Louis

Edwardsville

Marcus

Rp2.678.956 total

includes taxes & fees

12 Nov - 13 Nov

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

19. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

Rp1.533.259 total

includes taxes & fees

1 Dec - 2 Dec

A hotel room with a bed, a television, a desk, and a chair.

20. Super 8 by Wyndham Greenville

Greenville

Sharon

Rp1.371.092 total

includes taxes & fees

22 Nov - 23 Nov

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Southwest Illinois attractions

O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Visit the shops and top-notch restaurants in this family-friendly area.

See properties

Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

See all hotels in Southwest Illinois

A tall, cylindrical structure with a red and white striped pattern and a label reading "Brock's Old Original Catsup."

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"The property is in a busy location right off the highway. Lots around to go eat at. The staff were wonderful! Very helpful! The afternoon 5-730 was ok nothing to speak of but let me tell you, the breakfast, was fantastic! So many options for everyone. Hotel had one elevator working for very busy hotel. We used the steps a lot. Just didn’t like the stairs let us out outside but nothing that we couldn’t handle. Overall, this hotel is a good choice and we would go back!"

Best Western St. Louis Fairview Heights

8/10 Good

"Much better than I expected for the price. Very quite and I had a great sleep. The room was dark and the bed was firm and comfortable. The shower head had plenty of pressure which was nice. I also was pleased with the breakfast selection. Yes, like other older hotels under new ownership, the place lacked attention to details, but for the price and location I recommend staying here."