Search Hotels in Lake Nona Medical City, Orlando

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10 Dec - 11 Dec
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Our top choices for Lake Nona Medical City hotels

Exterior
Aloft Orlando Lake Nona

Aloft Orlando Lake Nona

Aloft Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (261)
"Great staff and nice amenities. "
United States
David
The price is Rp1.901.064
Rp2.138.697 total
includes taxes & fees
22 Dec - 23 Dec
Aloft Orlando Lake Nona
Outdoor pool
Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (590)
"Great stay"
United States
Romulo
The price is Rp2.401.344
Rp2.728.527 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard Orlando Lake Nona
Outdoor pool
Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (325)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is Rp2.834.920
Rp3.221.137 total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn Orlando Lake Nona
Lobby
La Quinta Inn & Suites by Wyndham Orlando UCF

La Quinta Inn & Suites by Wyndham Orlando UCF

La Quinta Inn & Suites by Wyndham Orlando UCF
3.0 star property
25.4 km from Lake Nona Medical City
8.6 out of 10, Excellent, (2675)
"Great location and friendly staff!"
United States
Loren
The price is Rp1.459.984
Rp1.642.482 total
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Orlando UCF
Terrace/patio
The Delaney Hotel

The Delaney Hotel

The Delaney Hotel
3.5 star property
South Orange, 20.2 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (1019)
"The Hotel is wonderful had a great restaurant and bar the staff was very friendly and the room looked like the photos "
United States
Michael
The Delaney Hotel
Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing Accessible) | Premium bedding, in-room safe, desk, blackout curtains
Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (5164)
"Great place to stay close to airport "
United States
Rebekah
The price is Rp2.636.642
Rp2.966.221 total
includes taxes & fees
5 Jan - 6 Jan 2026
Ramada by Wyndham Suites Orlando Airport
Restaurant
Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3735)
"Good room, good breakfast and convenient to the airport."
United States
Mark
The price is Rp1.335.748
Rp1.502.841 total
includes taxes & fees
15 Dec - 16 Dec
Wingate by Wyndham - Orlando International Airport
5 outdoor pools, free pool cabanas, pool umbrellas
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
4.0 star property
International Drive District, 20 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2724)
"Stayed here before always enjoyed it "
United States
Margaret
The price is Rp1.600.896
Rp1.801.007 total
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
Fitness facility
Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport
3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4014)
"Very clean hotel and easy experience checking in and out "
United States
Arielle
The price is Rp1.360.762
Rp1.531.024 total
includes taxes & fees
15 Dec - 16 Dec
Wyndham Garden Orlando Airport
Exterior
La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (826)
"Near the beach , very nice people at the reception. "
United States
Leonie
The price is Rp1.320.739
Rp1.485.831 total
includes taxes & fees
17 Dec - 18 Dec
La Quinta Inn & Suites by Wyndham Orlando Airport North
6 outdoor pools, free pool cabanas, pool umbrellas
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
4.0 star property
22.5 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4068)
"Very clean best resort "
United States
Shatira
The price is Rp1.854.371
Rp2.086.168 total
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Property grounds
SPOT X Hotel Orlando/Intl Dr by The Red Collection

SPOT X Hotel Orlando/Intl Dr by The Red Collection

SPOT X Hotel Orlando/Intl Dr by The Red Collection
3.0 star property
21 km from Lake Nona Medical City
8.6 out of 10, Excellent, (2942)
"Clean room, close to Disney and good breakfast at a reasonable price"
United States
pamela
The price is Rp1.260.706
Rp1.718.294 total
includes taxes & fees
14 Dec - 15 Dec
SPOT X Hotel Orlando/Intl Dr by The Red Collection
Lobby lounge
Aloft Orlando Lake Buena Vista

Aloft Orlando Lake Buena Vista

Aloft Orlando Lake Buena Vista
3.0 star property
21.7 km from Lake Nona Medical City
8.8 out of 10, Excellent, (1906)
"Great rooms, staff, and property!"
United States
Cindy
The price is Rp1.234.024
Rp1.388.276 total
includes taxes & fees
14 Dec - 15 Dec
Aloft Orlando Lake Buena Vista
Reception
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks
3.0 star property
30.8 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (1948)
"Beautiful resort with very friendly staff. "
United States
kristie
The price is Rp759.425
Rp1.524.211 total
includes taxes & fees
11 Dec - 12 Dec
Kompose Boutique Resort at Theme Parks
Courtyard
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6892)
"Wonderful stay. Great location!"
United States
Charmaine
The price is Rp1.490.501
Rp1.676.814 total
includes taxes & fees
16 Dec - 17 Dec
DoubleTree by Hilton at the Entrance to Universal Orlando
Lobby
Orlando Palms Hotel

Orlando Palms Hotel

Orlando Palms Hotel
2.5 star property
14.9 km from Lake Nona Medical City
7.6 out of 10, Good, (2234)
"Very friendly staff."
United States
Lynn
The price is Rp686.381
Rp971.227 total
includes taxes & fees
11 Dec - 12 Dec
Orlando Palms Hotel
View from property
Avanti International Resort

Avanti International Resort

Avanti International Resort
4.0 star property
International Drive District, 20.8 km from Lake Nona Medical City
7.8 out of 10, Good, (4294)
"Enjoyed our stay "
United States
Sheltra
The price is Rp1.156.609
Rp1.638.874 total
includes taxes & fees
14 Dec - 15 Dec
Avanti International Resort
Meeting facility
Hampton Inn & Suites Orlando Intl Dr N

Hampton Inn & Suites Orlando Intl Dr N

Hampton Inn & Suites Orlando Intl Dr N
2.5 star property
International Drive District, 21.6 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (1073)
"Second time staying at this hotel and loved it great hotel for family and close to the main attractions "
United States
Kadeisha
The price is Rp1.496.838
Rp1.683.943 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites Orlando Intl Dr N
Exterior
Courtyard by Marriott Orlando Downtown

Courtyard by Marriott Orlando Downtown

Courtyard by Marriott Orlando Downtown
3.0 star property
23.1 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (1001)
"Beautiful hotel & convenient location"
United States
John
The price is Rp1.717.628
Rp1.932.333 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Orlando Downtown
Water park
Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area
4.0 star property
20.7 km from Lake Nona Medical City
8.2 out of 10, Very good, (5561)
"Clean room and staff was awesome "
United States
Shawanda
The price is Rp1.628.911
Rp2.395.174 total
includes taxes & fees
15 Dec - 16 Dec
Westgate Lakes Resort & Spa Universal Studios Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most. Learn more about Lake Nona Medical City
Learn more about Lake Nona Medical City

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Magic Kingdom® Theme Park showing interior views and rides as well as a couple
Photo by ©Disney
Open Photo by ©Disney

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Universal Studios Florida® featuring night scenes, a city and signage

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

Top Lake Nona Medical City Hotel Reviews

Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

10/10 Excellent
"Clean room and amenities matched advertisement "
Blake 7-night trip
Posted 1 day ago
Universal's Cabana Bay Beach Resort

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Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.