Southeast Missouri Travel Guide

Tourist Guide

A group of men in red uniforms with gold accents, holding rifles and wearing kilts.
A river flowing through a rocky landscape with dense green forest in the background.
A rocky river with clear water flowing over rocks.
A rocky shoreline with a calm lake and distant islands.
A river running through a forested landscape with a dirt road parallel to the river.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is Rp1.772.123 per night from 6 Sept to 7 Sept
Rp1.772.123
Rp1.999.203 total
6 Sept - 7 Sept
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,003 reviews)
"Competitively priced. Complimentary happy hour and hot breakfast were exceptional. We stay at a Drury Inn whenever they are available."

Reviewed on 27 Aug 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
The price is Rp1.063.380 per night from 20 Sept to 21 Sept
Rp1.063.380
Rp1.157.489 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking and an outdoor pool. Our guests praise the helpful staff and the clean ...
8/10 Very good! (1,001 reviews)
"It was a nice stay"

Reviewed on 25 Aug 2026

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
The price is Rp2.025.739 per night from 31 Aug to 1 Sept
Rp2.025.739
Rp2.285.204 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free Wi-Fi, free parking and 2 restaurants. Popular attractions Century Casino & Hotel Cape Girardeau ...
9.4/10 Exceptional! (647 reviews)
"Nice view of the river. The staff was nice."

Reviewed on 23 Aug 2026

The Riverview
See all 686 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios and climate control.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
Lake Wappapello
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
The Atrium - A Boutique Hotel
See all properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Things to do

Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

Rp227.728
per adult
90% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

Rp357.041
per adult
96% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Tour The Ozarks Private Springfield Brewery Tour

Rp3.819.039
per adult
Tour The Ozarks Private Springfield Brewery Tour
See all activities in Southeast Missouri

Cities near Southeast Missouri

A city skyline at dusk with a prominent bridge arching over a body of water.

Festus

A cable-stayed bridge over a river with a clear sky.

Alton

A city skyline with a prominent arch bridge over a river, featuring several high-rise buildings and boats on the water.

Ste Genevieve

A sunset over a calm lake with a rocky shoreline and trees in the background.

Wappapello