A calm river with clear water, surrounded by dense trees and rocky banks.

Find hotels in O Brien, FL from Rp1.120.888

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Check prices for these dates

Tonight
14 Aug - 15 Aug
Tomorrow
15 Aug - 16 Aug
This weekend
14 Aug - 16 Aug
Next weekend
21 Aug - 23 Aug

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Our top choices for O Brien hotels

1. Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
United States
Michael
Rp1.948.593
Rp2.192.257 total
includes taxes & fees
16 Aug - 17 Aug
Tru by Hilton Lake City

2. Comfort Suites Lake City

Comfort Suites Lake City
Lake City
United States
KHAJA
Rp1.753.555
Rp1.972.749 total
includes taxes & fees
21 Aug - 22 Aug
Comfort Suites Lake City

3. Best Western Plus Lake City

Best Western Plus Lake City
Lake City
United States
James
Rp1.496.484
Rp1.683.544 total
includes taxes & fees
6 Sept - 7 Sept
Best Western Plus Lake City

4. Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
Live Oak
United States
Patricia
Rp1.494.517
Rp1.643.968 total
includes taxes & fees
20 Aug - 21 Aug
Quality Inn & Suites Live Oak I-10 Exit 283

5. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
United States
Justo
Rp1.948.593
Rp2.192.167 total
includes taxes & fees
23 Aug - 24 Aug
Hampton Inn & Suites Lake City

6. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
White Springs
United States
Rowan
Rp1.018.989
Rp1.120.888 total
includes taxes & fees
17 Aug - 18 Aug
Quality Inn White Springs Suwanee

7. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
Lake City
United States
Mari
Rp1.170.050
Rp1.316.306 total
includes taxes & fees
16 Aug - 17 Aug
Super 8 by Wyndham Lake City

8. Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
Lake City
United States
Serhii
Rp1.058.318
Rp1.190.607 total
includes taxes & fees
16 Aug - 17 Aug
Days Inn by Wyndham Lake City I-10

9. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
United States
Priscilla J
Rp1.673.287
Rp1.882.448 total
includes taxes & fees
6 Sept - 7 Sept
La Quinta Inn & Suite by Wyndham Lake City

10. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
United States
William
Rp2.187.430
Rp2.460.948 total
includes taxes & fees
23 Aug - 24 Aug
Home2 Suites by Hilton Lake City

11. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
United States
Adoniram
Rp1.914.627
Rp2.153.955 total
includes taxes & fees
21 Aug - 22 Aug
Fairfield Inn & Suites Lake City

12. Cindys Motel

Cindys Motel
Mayo
United States
Diane
Rp1.568.707
Rp1.695.455 total
includes taxes & fees
17 Aug - 18 Aug
Cindys Motel

13. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
Lake City
United States
Pennee
Rp1.162.005
Rp1.307.255 total
includes taxes & fees
16 Aug - 17 Aug
Motel 6 – Lake City, Fl – Medical Center

14. Regal Inn

Regal Inn
Lake City
United States
Samuel
Rp1.109.089
Rp1.247.636 total
includes taxes & fees
16 Aug - 17 Aug
Regal Inn

15. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
United States
Larissa
Rp1.158.430
Rp1.303.233 total
includes taxes & fees
16 Aug - 17 Aug
Americas Best Value Inn Lake City

16. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
Lake City
United States
Jasmine
Rp1.033.291
Rp1.162.541 total
includes taxes & fees
16 Aug - 17 Aug
Baymont by Wyndham Lake City I-75

17. Quality Inn Lake City

Quality Inn Lake City
Lake City
United States
Lucille
Rp1.306.809
Rp1.470.160 total
includes taxes & fees
13 Sept - 14 Sept
Quality Inn Lake City

18. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
Lake City
United States
Brizheet
Rp1.129.826
Rp1.271.054 total
includes taxes & fees
16 Aug - 17 Aug
Days Inn by Wyndham Lake City I-75

19. Econo Lodge Live Oak

Econo Lodge Live Oak
Live Oak
United States
James
Rp1.307.703
Rp1.438.383 total
includes taxes & fees
16 Aug - 17 Aug
Econo Lodge Live Oak

20. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City
United States
Renee
Rp1.698.315
Rp1.910.604 total
includes taxes & fees
13 Sept - 14 Sept
Holiday Inn & Suites Lake City by IHG
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Comfort Suites Lake City

Comfort Suites Lake City

10/10 Excellent
"Roomy and spacious place to spend the night. Returning next month."
David 1-night trip
Posted 1 hour ago
Comfort Suites Lake City
Quality Inn Lake City

Quality Inn Lake City

8/10 Good
"Clean room, comfortable beds and a lot of hot water. Staff very helpful, nice young ladies. Stayed here last month, liked it then and liked it this time. My only suggestion is a little more variety on the breakfast. It's weak."
Michael S 1-night trip
Posted 10 hours ago
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

10/10 Excellent
"Clean room, comfortable bed, and good breakfast."
Randy 1-night trip
Posted 14 hours ago
Best Western Plus Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

10/10 Excellent
"Friendly and helpful staff. Breakfast was great and bed was comfortable!"
chari 1-night trip
Posted 18 hours ago
Tru by Hilton Lake City
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

8/10 Good
"clean room , friendly staff, good overnight stay "
Dennis 1-night trip
Posted 23 hours ago
Baymont by Wyndham Lake City I-75
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

10/10 Excellent
"Everything"
Beatrice 1-night trip
Posted 1 day ago
Courtyard By Marriott Lake City

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

3430 N Us Highway 441 Lake City FL
Rp1.058.318
Rp1.190.607 total
16 Aug - 17 Aug
includes taxes & fees
Days Inn by Wyndham Lake City I-10
Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
Rp1.306.809
Rp1.470.160 total
13 Sept - 14 Sept
includes taxes & fees
8.2/10 Very good! (1,002 reviews)
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
Rp1.496.484
Rp1.683.544 total
6 Sept - 7 Sept
includes taxes & fees
9/10 Wonderful! (1,097 reviews)
Best Western Plus Lake City
Comfort Suites Lake City

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL
Rp1.753.555
Rp1.972.749 total
21 Aug - 22 Aug
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Comfort Suites Lake City
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

15930 Northwest 163rd Lane Alachua FL
Rp1.891.029
Rp2.127.408 total
23 Aug - 24 Aug
includes taxes & fees
Hampton Inn & Suites Alachua I-75
Tru by Hilton Lake City

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL
Rp1.948.593
Rp2.192.257 total
16 Aug - 17 Aug
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
Tru by Hilton Lake City

Frequently asked questions

Where is the best place to stay in O Brien?
Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Best Western Plus Lake City: Features a snack bar/deli, an indoor pool and buffet. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

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