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23 Dec - 24 Dec
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Our top choices for Odessa Regional Medical Center hotels

Outdoor pool, open 10:00 AM to 10:00 PM, pool cabanas (surcharge)
Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center
4.0 star property
0.2 km from Odessa Regional Medical Center
9.2 out of 10, Wonderful, (464)
"Rooms and hotel were great"
United States
John
The price is Rp2.998.250
Rp3.447.988 total
includes taxes & fees
1 Jan - 2 Jan 2026
Odessa Marriott Hotel & Conference Center
Free breakfast
Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG
2.5 star property
3.1 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (467)
"Room was nicely cleaned & staff was very polite. "
United States
Mariano
The price is Rp1.677.700
Rp1.948.648 total
includes taxes & fees
23 Jan - 24 Jan 2026
Holiday Inn Express & Suites Odessa I-20 by IHG
Lobby
Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street
2.0 star property
1.9 km from Odessa Regional Medical Center
7.8 out of 10, Good, (500)
"Clean, quiet and a good price. The management here is quat"
United States
Ronald
The price is Rp1.004.833
Rp1.155.583 total
includes taxes & fees
24 Dec - 25 Dec
Motel 6 Odessa, TX - 2nd Street
Desk, laptop workspace, blackout curtains, iron/ironing board
MainStay Suites Odessa I-20

MainStay Suites Odessa I-20

MainStay Suites Odessa I-20
2.5 star property
3 km from Odessa Regional Medical Center
8.2 out of 10, Very good, (299)
"Very clean very spacious rooms friendly staff loved it"
United States
Jamayea
The price is Rp1.259.114
Rp1.447.981 total
includes taxes & fees
25 Dec - 26 Dec
MainStay Suites Odessa I-20
Suite, 1 King Bed, Jetted Tub, Pool View (with Sofabed) | View from room
SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa
3.0 star property
2.7 km from Odessa Regional Medical Center
7.4 out of 10, Good, (76)
"Very nice place to stay "
United States
Jerry
The price is Rp1.407.000
Rp1.618.051 total
includes taxes & fees
24 Dec - 25 Dec
SureStay Plus Hotel by Best Western Odessa
Room, Non Smoking | Rollaway beds, free WiFi
Villa West Inn

Villa West Inn

Villa West Inn
2.0 star property
2.6 km from Odessa Regional Medical Center
7.4 out of 10, Good, (178)
"Clean room, clean toilet and good staffs."
United States
Francis
The price is Rp1.005.000
Rp1.155.750 total
includes taxes & fees
24 Dec - 25 Dec
Villa West Inn
Living area
DELUX INN

DELUX INN

DELUX INN
2.5 star property
2.5 km from Odessa Regional Medical Center
6.8 out of 10, (24)
"Best hotel "
United States
Poncho
The price is Rp1.088.750
Rp1.252.063 total
includes taxes & fees
24 Dec - 25 Dec
DELUX INN
Blackout curtains, free WiFi, bed sheets
Motel 6 Odessa, TX

Motel 6 Odessa, TX

Motel 6 Odessa, TX
2.0 star property
2.8 km from Odessa Regional Medical Center
6.8 out of 10, (552)
"The room was very clean. And management was very helpful."
United States
Bonnie
The price is Rp1.071.833
Rp1.232.633 total
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Odessa, TX
Children’s area
Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG
3.0 star property
4.6 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (144)
"Excellent "
United States
Jeannette
The price is Rp1.323.250
Rp1.521.737 total
includes taxes & fees
29 Dec - 30 Dec
Staybridge Suites Odessa - Interstate HWY 20 by IHG
Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool loungers
Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa
3.5 star property
4.7 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (267)
"Clean room, reasonable price and restaurant on site which was perfect after a long day of driving"
United States
Kimberly
The price is Rp1.492.425
Rp1.716.288 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hawthorn Extended Stay by Wyndham Odessa
Property amenity
Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG
2.5 star property
4.6 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (190)
"It was a smaller place than i have stayed before, it does not have a pool, but still great place to stay."
United States
Alice
The price is Rp1.474.000
Rp1.695.100 total
includes taxes & fees
29 Dec - 30 Dec
Candlewood Suites Odessa by IHG
Lobby
TownePlace Suites by Marriott Odessa

TownePlace Suites by Marriott Odessa

TownePlace Suites by Marriott Odessa
3.0 star property
5.4 km from Odessa Regional Medical Center
9.0 out of 10, Wonderful, (513)
"Great service and breakfast was very good."
United States
Iris
The price is Rp1.551.887
Rp1.784.670 total
includes taxes & fees
29 Dec - 30 Dec
TownePlace Suites by Marriott Odessa
Full-sized fridge, microwave
Parkway Inn

Parkway Inn

Parkway Inn
2.0 star property
5 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (32)
"Nice and remodeled rooms "
United States
Eleuterio
The price is Rp1.283.440
Rp1.475.957 total
includes taxes & fees
24 Dec - 25 Dec
Parkway Inn
Desk, laptop workspace, blackout curtains, iron/ironing board
Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University
2.5 star property
5.2 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (466)
"Very good"
United States
Sharmin
The price is Rp1.067.813
Rp1.227.984 total
includes taxes & fees
17 Jan - 18 Jan 2026
Sleep Inn & Suites Odessa near University
Exterior
Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa
2.5 star property
5.3 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (411)
"We had a great stay! The staff was very friendly and helpful, especially Nizhoni at the front desk-she was amazing. The facility and rooms were clean, the beds were comfortable, and the complimentary breakfast had plenty of options. Would definitely stay here again. "
United States
Karinna
The price is Rp1.409.512
Rp1.655.993 total
includes taxes & fees
31 Dec - 1 Jan 2026
Fairfield Inn & Suites Odessa
View from room
MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa
3.5 star property
6 km from Odessa Regional Medical Center
9.0 out of 10, Wonderful, (1005)
"incredible stay at a 5 star hotel in Odessa Texas. Room was clean; Staff was excellent; Food was delicious. was pleasantly surprised. will stay out there again while visiting family & friends!"
United States
Patricia
The price is Rp1.676.005
Rp1.927.255 total
includes taxes & fees
25 Dec - 26 Dec
MCM Elegante Hotel and Conference Center Odessa
Full-sized fridge, microwave, stovetop, coffee/tea maker
Studio 6 Odessa, TX

Studio 6 Odessa, TX

Studio 6 Odessa, TX
2.5 star property
4.6 km from Odessa Regional Medical Center
8.0 out of 10, Very good, (241)
"The staff was very welcoming and accommodating. I was able to check in early and my room was clean, sanitized, and ready. Not the most modern motel but definitely worth the value."
United States
Mark
The price is Rp1.172.333
Rp1.348.208 total
includes taxes & fees
25 Dec - 26 Dec
Studio 6 Odessa, TX
Outdoor pool
Hampton Inn by Hilton Odessa

Hampton Inn by Hilton Odessa

Hampton Inn by Hilton Odessa
2.5 star property
5.3 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (367)
"Always a great place to stay!!!"
United States
Xavier
The price is Rp1.579.525
Rp1.834.543 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn by Hilton Odessa
Lobby
Sonesta Essential Hotels Odessa

Sonesta Essential Hotels Odessa

Sonesta Essential Hotels Odessa
2.0 star property
4.5 km from Odessa Regional Medical Center
7.8 out of 10, Good, (749)
"Nice place"
United States
Jose
The price is Rp1.658.250
Rp1.906.988 total
includes taxes & fees
29 Dec - 30 Dec
Sonesta Essential Hotels Odessa
Lobby
Comfort Inn & Suites, Odessa I-20

Comfort Inn & Suites, Odessa I-20

Comfort Inn & Suites, Odessa I-20
2.5 star property
4.6 km from Odessa Regional Medical Center
7.8 out of 10, Good, (570)
"Room was clean and comfortable "
United States
Dolores
The price is Rp1.269.180
Rp1.459.557 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites, Odessa I-20
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Odessa Regional Medical Center Hotel Reviews

MCM Grande Hotel FunDome Odessa

MCM Grande Hotel FunDome Odessa

10/10 Excellent
"Everything seems great"
shawn 1-night trip
Posted 2 days ago
MCM Grande Hotel FunDome Odessa

Hotels near other Odessa Regional Medical Center attractions

Odessa Jackrabbit Statue

You can learn about the history of Odessa when you stop by Odessa Jackrabbit Statue. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

White-Pool House

4.3/5 (20 reviews)
You can find out about the history of Odessa when you stop by White-Pool House. Experience the area's entertainment venues or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Odessa Regional Medical Center?
Odessa Regional Medical Center is located in Odessa. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 15 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Odessa Regional Medical Center?
Adjacent to Odessa Regional Medical Center, Odessa Marriott Hotel & Conference Center is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices within a few miles include MCM Grande Hotel FunDome Odessa and MCM Elegante Hotel and Conference Center Odessa.
How many hotels can I expect to find near Odessa Regional Medical Center?
Expedia has 15 hotels and other accommodation options within a mile from Odessa Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Odessa Regional Medical Center, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then use the "fully refundable" filter to review the best deals near Odessa Regional Medical Center.
What can I see and do near Odessa Regional Medical Center?
Study the collections at White-Pool House, Ellen Noel Art Museum or Parker House Museum. Create some family memories at Altitude Trampoline Park and Fun City. Attractions like Globe of the Great Southwest and Presidential Museum and Leadership Library highlight the local culture.