The Best Hotels in Jefferson, San Antonio - 2026 Updated Prices

The Alamo, a historic building with a prominent arched entrance and a flagpole in front.

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Our top choices for Jefferson hotels

A self-service snack and drink vending area with multiple shelves stocked with various products.

1. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District, 6.3 km from Jefferson

Juan

Rp1.864.051 total

includes taxes & fees

23 Sept - 24 Sept

A modern kitchen with a central island, built-in appliances, and a coffee station.

2. Wyndham Garden San Antonio Airport

Uptown Central, 8.4 km from Jefferson

SWAROOP JADHAV

Rp1.796.301 total

includes taxes & fees

27 Sept - 28 Sept

A modern lobby with a sofa, patterned chairs, a central ottoman, and a chandelier.

3. Drury Plaza Hotel San Antonio Airport

8.2 km from Jefferson

Jay

Rp2.392.827 total

includes taxes & fees

4 Oct - 5 Oct

A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

4. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Uptown Central, 8.4 km from Jefferson

Aaron

Rp1.679.196 total

includes taxes & fees

4 Oct - 5 Oct

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

5. Courtyard by Marriott Medical Center San Antonio

Medical Center District, 7.1 km from Jefferson

Erik

Rp1.870.348 total

includes taxes & fees

2 Oct - 3 Oct

A spacious lobby with a modern design, featuring a large seating area with sofas and armchairs, a patterned rug, and a reception desk.

6. Comfort Inn and Suites Near Medical Center

2.6 km from Jefferson

Kalkidan

Rp1.240.902 total

includes taxes & fees

18 Oct - 19 Oct

A modern bar area with seating and a staircase leading to an upper level.

7. Embassy Suites by Hilton San Antonio Airport

Uptown Central, 9.1 km from Jefferson

Arianna

Rp2.664.099 total

includes taxes & fees

28 Sept - 29 Sept

A lobby with marble floors, teal chairs, and a central elevator.

8. Hotel Gibbs Downtown Riverwalk

Downtown San Antonio, 6.2 km from Jefferson

Mikayla

Rp1.673.682 total

includes taxes & fees

27 Sept - 28 Sept

A modern kitchen with a wooden countertop, a coffee station, and a food display.

9. Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB

8.9 km from Jefferson

Sonaida

Rp1.392.186 total

includes taxes & fees

11 Oct - 12 Oct

A breakfast bar with various food items and kitchen appliances.

10. Spark by Hilton San Antonio Airport

9.3 km from Jefferson

Carla

Rp1.495.892 total

includes taxes & fees

1 Oct - 2 Oct

A spacious living area with a dark blue sofa, four grey armchairs, and three metallic coffee tables.

11. La Quinta Inn & Suites by Wyndham San Antonio Airport

8.3 km from Jefferson

Gonzalo

Rp1.662.504 total

includes taxes & fees

4 Oct - 5 Oct

A riverboat with a pink and blue exterior, surrounded by buildings with balconies and a palm tree.

12. Hotel Valencia Riverwalk

Downtown San Antonio, 5.9 km from Jefferson

Skylar

Rp4.041.275 total

includes taxes & fees

24 Sept - 25 Sept

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

13. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District, 8.1 km from Jefferson

Maribel

Rp1.889.029 total

includes taxes & fees

5 Oct - 6 Oct

An outdoor pool area with a stone wall, a water fountain, and a bridge connecting different levels.

14. Drury Plaza Hotel San Antonio Riverwalk

Downtown San Antonio, 6.1 km from Jefferson

Rebekah

Rp2.686.709 total

includes taxes & fees

27 Sept - 28 Sept

A hotel with a modern design, featuring a covered parking area and multiple parking spaces.

15. Best Western Medical Center North Inn & Suites Near Six Flags

Northwest Side, 11 km from Jefferson

Gerald

Rp1.378.917 total

includes taxes & fees

29 Sept - 30 Sept

A modern Hyatt Place hotel with a glass entrance, stone pillars, and a covered walkway.

16. Hyatt Place San Antonio–North/Stone Oak

Stone Oak, 18.2 km from Jefferson

Esther

Rp2.309.071 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a beige sofa, a chandelier, a staircase, and a large window overlooking a parking area.

17. Days Inn by Wyndham San Antonio Airport

Uptown Central, 8.8 km from Jefferson

Jennifer

Rp1.145.956 total

includes taxes & fees

11 Oct - 12 Oct

A compact kitchen with a microwave and a refrigerator built into a wooden cabinet.

18. Red Roof Inn San Antonio - Airport

Uptown Central, 8.9 km from Jefferson

Heaven Leigh

Rp944.431 total

includes taxes & fees

28 Sept - 29 Sept

An outdoor patio with a stone fire pit, wicker furniture, and string lights.

19. Courtyard by Marriott San Antonio Downtown/Market Square

5.9 km from Jefferson

Brian

Rp2.342.657 total

includes taxes & fees

8 Oct - 9 Oct

A Holiday Inn Express reception desk with a modern design, featuring a large illuminated sign, a reception area, and a potted plant.

20. Holiday Inn Express San Antonio-Airport by IHG

8.2 km from Jefferson

Liz

Rp2.130.773 total

includes taxes & fees

27 Sept - 28 Sept

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Where to stay in Jefferson

Find the best Jefferson areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A riverside walkway with colorful umbrellas, a stone bridge, and historic buildings.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A riverside walkway adorned with colorful umbrellas and festive lights.

Uptown Central

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

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A cityscape with a prominent tower, a large body of water, and a sunset.

Medical Center District

While Medical Center District isn't home to many top sights, Wonderland of the Americas Mall and Huebner Oaks are some notable places to visit nearby.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

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Top Jefferson Hotel Reviews

Omni La Mansion del Rio

10/10 Excellent

"Great location."

The Westin San Antonio North

8/10 Good

"Do not pay for breakfast through Expedia.the hotel knows nothing about it and now I have to apply for a refund. Hotel is very dated. It must have been a very plush place at one time. It is still nice and the staff were very pleasant. Most of the electrical plugs are on the lamps the bed is Heavenly."

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

10/10 Excellent

"It was an excellent experience with friendly and helpful staff. They assisted with my request for early check-in and late check-out. The hotel offers a complete breakfast, is family and dog friendly, and is near Six Flags. It's a good option to consider on your next trip."

Hyatt Regency Hill Country Resort and Villas

10/10 Excellent

"Very clean room and facilities! The room was very spacious (we had a 1 king bed room) and designed to be very homey. The lazy river and slide were the highlight for my husband and 6 year old, spent all day there with poolside food service. The lagoon was beautiful and clean, and it’s probably best for toddlers or families who want some quiet calm swim time (whereas the lazy river and slide area are more exciting). One tip about the lagoon—id say about 40% of it is roped off as a swim area near the shore, while the rest of it is for rental boating only, so my high energy 6 year was a bit disappointed that he couldn’t swim out far into the lagoon. That being said it’s a beautiful spot to relax and have some peace and quiet."

Frequently asked questions

What is Jefferson like?

Travellers to San Antonio's Jefferson neighbourhood will be sure to enjoy a stay here. Consider a visit to Woodlawn Lake Park as part of your Jefferson travel plans.

How many hotels should I expect to find in Jefferson?

Expedia has 43 hotels and other accommodation options in Jefferson to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Jefferson, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within a 24-hour period of booking. Add dates, click "Search", then you can use the "fully refundable" filter to review the top deals on offer in Jefferson.

What are the top things to see and do in Jefferson?

Woodlawn Lake Park is an attraction you might want to check out while you're in Jefferson. While you're out sightseeing in San Antonio, make sure that you visit other sights such as Woodlawn Theater or The Starlighter.

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Our top choices for Jefferson hotels

1. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2. Wyndham Garden San Antonio Airport

3. Drury Plaza Hotel San Antonio Airport

4. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

5. Courtyard by Marriott Medical Center San Antonio

6. Comfort Inn and Suites Near Medical Center

7. Embassy Suites by Hilton San Antonio Airport

8. Hotel Gibbs Downtown Riverwalk

9. Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB

10. Spark by Hilton San Antonio Airport

11. La Quinta Inn & Suites by Wyndham San Antonio Airport

12. Hotel Valencia Riverwalk

13. Drury Inn & Suites San Antonio Northwest Medical Center

14. Drury Plaza Hotel San Antonio Riverwalk

15. Best Western Medical Center North Inn & Suites Near Six Flags

16. Hyatt Place San Antonio–North/Stone Oak

17. Days Inn by Wyndham San Antonio Airport

18. Red Roof Inn San Antonio - Airport

19. Courtyard by Marriott San Antonio Downtown/Market Square

20. Holiday Inn Express San Antonio-Airport by IHG

Where to stay in Jefferson

Downtown San Antonio

Far West Side

Uptown Central

Medical Center District

Northwest Side

Top Jefferson Hotel Reviews

Omni La Mansion del Rio

Frequently asked questions

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