Santa Ana Holidays

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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
9/10 Wonderful! (74 reviews)
The room was spotless and the decor was beautiful. The location was very convenient and the staff was friendly, in particular Marciello. The only downsides were that there was no hot water in the shower and the air conditioning vented onto the deck, making it really hot to sit on the deck.

Reviewed on 22 Feb 2026

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Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is Rp2.374.334 per night from 8 Mar to 9 Mar
Rp2.374.334
Rp2.611.767 total
8 Mar - 9 Mar
includes taxes & fees
9/10 Wonderful! (5,047 reviews)
The amenities were great! The food at the buffet wasnt all thay great tho. Also, tje menu was the same at each restaurant. The quality wasnt great.bthe rooms were clean and the staff was frie

Reviewed on 2 Mar 2026

Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is Rp1.812.996 per night from 23 Mar to 24 Mar
Rp1.812.996
Rp1.994.296 total
23 Mar - 24 Mar
includes taxes & fees
7.8/10 Good! (1,007 reviews)
No I was very disappointed. My room had bed bugs and i was but really bad .which means things are not cleaned or checked as they should be . I do not want to return here as that problem continues im upset beyond measures.

Reviewed on 1 Mar 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
See all 1,564 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana holiday package cost?
From as little as . Yes, you read that correctly. Our Santa Ana holiday packages are an easy way to stretch your budget further. Combine your favourite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana holiday.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favourites among lots of travellers.
How far in advance should I book my Santa Ana holiday?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana holiday package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana holiday package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Popular places to visit

Old and traditional Yatch Club at Cinta Costera, Panama City, Panama.

Cinta Costera

4/5(5 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera

Albrook Shopping Mall

4/5(5 reviews)

During your trip to Ancon, you can do some window-shopping at Albrook Shopping Mall. Amble around this culturally rich area's seaside and enjoy its top-notch restaurants.

Albrook Shopping Mall

Crown Casino

Why not roll the dice with a visit to Crown Casino during your visit to Panama City? Stroll along the seaside or visit the shops in this vibrant area.

Crown Casino

Things to do

Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

Rp1.329.096
per adult
100% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City

All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City

Rp1.663.695
per adult
96% of travellers recommend
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City
Panama Canal Half Transit Experience

Panama Canal Partial Transit

Rp2.523.600
per adult
84% of travellers recommend
Panama Canal Partial Transit
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.