Santa Cruz Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to Rp16.000.000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Equipetrol

When in Equipetrol, you can plan a visit to Santa Cruz Zoo and Municipal Library, some noteworthy sights in the nearby area.

Centro Histórico

If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.

Hamacas

When in Hamacas, you can plan a visit to Las Brisas Shopping Center and Santa Cruz Zoo, some noteworthy sights in the nearby area.

Zona Sur (South Zone)

Though Zona Sur (South Zone) may not have many top sights, you can venture to the surrounding area to see attractions like Ramon Tahuichi Aguilera Stadium and Plaza 24 de Septiembre.

Urubó

While there might not be top attractions in Urubó, you can explore the larger area and discover places like Guembe Biocenter and Ventura Mall.

Top hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is Rp644.692 per night from 25 Nov to 26 Nov
Rp644.692
Rp644.692 total
25 Nov - 26 Nov
Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is Rp2.752.241 per night from 14 Nov to 15 Nov
Rp2.752.241
Rp2.752.241 total
14 Nov - 15 Nov
9/10 Wonderful! (426 reviews)
"Beautiful hotel with so many things to explore. Pools and surrounding area are clean and well maintained. Staff are friendly and they are always around and so helpful. Room was exceptionally clean. The beautiful balcony leading out to the garden is just incredible. Breakfast was also incredible. ..."

Reviewed on 8 Nov 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is Rp2.229.469 per night from 14 Nov to 15 Nov
Rp2.229.469
Rp2.229.469 total
14 Nov - 15 Nov
9/10 Wonderful! (261 reviews)
"Beautiful views and clean property. The food there is great, and it’s well located. However, the cleaning staff stole a $100 bill from my backpack and replaced it with a fake one. I would rather they just took the money, but replacing it with a fake note could’ve gotten me in serious trouble, and ..."

Reviewed on 30 Oct 2026

Marriott Santa Cruz de la Sierra Hotel
See all 347 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz holiday package cost?
We make it simple to travel the world, with Santa Cruz holiday packages starting from as little as . You'll have the flexibility to combine your favourite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cosy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz holiday?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favourite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz holiday package is the most convenient way to organise your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia holiday package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organising your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz holiday package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz holiday package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
See properties

What to do in Santa Cruz

Samaipata, Andes Adventure: El Codo De Los Andes Hike

Samaipata, Andes Adventure: El Codo De Los Andes Hike

Rp2.727.325
per adult
Samaipata, Andes Adventure: El Codo De Los Andes Hike
Vallegrande City

Vallegrande City Tour: History, Culture, and Flavor

Rp521.014
per adult
Vallegrande City Tour: History, Culture, and Flavor
Common grave, where the body of Che Guevara was found in 1997.

CITY TOURS RUTA DEL CHE: Walking Tour Real Scenarios

Rp179.660
per adult
CITY TOURS RUTA DEL CHE: Walking Tour Real Scenarios
See all activities in Santa Cruz
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.