Search Hotels in Serra Mesa, San Diego
Change your mind
Be picky
Go beyond your typical stay in Serra Mesa
Check prices for these dates
Top Trending Hotels Near Serra Mesa, San Diego
Our top choices for Serra Mesa hotels

Balboa Park Hotel
Balboa Park Hotel

The Beau Downtown San Diego Gaslamp Quar
The Beau Downtown San Diego Gaslamp Quar

Heritage Inn San Diego
Heritage Inn San Diego

Coronado Beach Resort
Coronado Beach Resort

Sun Outdoors San Diego Bay
Sun Outdoors San Diego Bay

Heritage Inn La Mesa
Heritage Inn La Mesa
Where to stay in Serra Mesa

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top San Diego neighborhoods
- Hotels in Downtown San Diego
- Hotels in Mission Beach
- Hotels in Pacific Beach
- Hotels in Gaslamp Quarter
- Hotels in Ocean Beach
- Hotels in Point Loma
- Hotels in Mission Valley
- Hotels in Central Mission Beach
- Hotels in Old Town San Diego
- Hotels in Little Italy
- Hotels in North Pacific Beach
- Hotels in South Mission Beach
- Hotels in Crown Point
- Hotels in Del Cerro
- Hotels in Carmel Valley
- Hotels in Mid-City
- Hotels in Hillcrest
- Hotels in North Park
- Hotels in Torrey Pines
- Hotels in East Village
More accommodation types in Serra Mesa
Hotels Close to Nearby Airports
Hotels in Serra Mesa by Star Rating
Explore more hotels
More ways to book
Expedia's Latest Trends
- 4 Star Hotels in Beverlywood
- Hotels with smoking rooms in West Cirebon
- Hotel Bhinneka
- Cheap Hotels in Yogyakarta
- Best Inn Hotel
- Hotel Cham Cham - Taipei
- Hotels in Downtown Los Angeles
- Solo Villas and Retreat
- Outpost Penestanan
- Hakone Ashinoko Hanaori
- Gino Feruci Braga
- Amaroossa Suite Bali
- Hotels near Malioboro Street
- Mimpi Resort Menjangan
- Hotels in Union Square
- Hotels near Batam Centre Ferry Terminal