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Check prices for these dates

Tonight
7 Nov - 8 Nov
Tomorrow
8 Nov - 9 Nov
Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov

Our top choices for St. Charles hotels with a spa

A reception desk with a modern design, a large abstract wall, and a seating area with a chair.

1. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,093 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is Rp2.879.769
Rp3.665.696 total
includes taxes & fees
22 Nov - 23 Nov
Ameristar Casino Resort and Spa
A reception area with a wooden counter, a staircase with a colorful mural, and a sign reading 'Locust Street Athletic and Swim Club.'

2. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,148 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is Rp2.588.536
Rp3.117.194 total
includes taxes & fees
15 Nov - 16 Nov
21C Museum Hotel St Louis
A hotel room with two beds, a framed picture on the wall, and a window with curtains.

3. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (587 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is Rp9.930.861
Rp11.593.421 total
includes taxes & fees
27 Nov - 28 Nov
The Ritz-Carlton, St. Louis
A modern hotel lobby with a glass facade, seating area, and a staircase.

4. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is Rp6.780.750
Rp7.928.595 total
includes taxes & fees
10 Nov - 11 Nov
Four Seasons Hotel St Louis
A well-lit lobby with a chandelier, potted plants, and a seating area.

5. Truitt Hotel

Truitt Hotel
2.0 star property
Lafayette Square
9.8 out of 10, Exceptional, (28 reviews)
The price is Rp3.038.952
Rp3.689.071 total
includes taxes & fees
8 Nov - 9 Nov
Truitt Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Charles

Pool
Hot tub

Top St. Charles Hotel Reviews

A modern hotel lobby with a glass facade, seating area, and a staircase.
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis

10/10 Excellent

Connected to a casino that is rough and smells of cigarettes
United Kingdom
Alethea
Reviewed March 12, 2025
Four Seasons Hotel St Louis

Frequently Asked Questions

Looking for a spa hotel in St. Charles?

Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travellers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your holiday. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your stay.

What is the best spa hotel in St. Charles?

Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness centre and an outdoor pool. Treat yourself to a facial, body scrub or hydrotherapy at Ara.

How many spa hotels will I find in St. Charles?

Among Expedia's 178 accommodation options in St. Charles, there is 1 spa hotel.

What's there to see and do in St. Charles?

Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail and Lewis & Clark Boathouse and Nature Center. If you have some spare time during your trip, you might want to check out St Charles Convention Center and Ameristar Casino St. Charles.

What is a St. Charles spa hotel?

Spa hotels in St. Charles provide lodging and have a full on-site spa which offers services such as couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.