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15 Aug - 16 Aug
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16 Aug - 17 Aug
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21 Aug - 23 Aug
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28 Aug - 30 Aug

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
Michelle
Rp3.230.374
Rp3.634.170 total
includes taxes & fees
17 Aug - 18 Aug
Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
United States
William
Rp3.230.374
Rp3.634.170 total
includes taxes & fees
17 Aug - 18 Aug
Orchid Key Inn - Adults Only

3. The Mermaid & Alligator

The Mermaid & Alligator
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
United States
Johnny
Rp3.668.360
Rp4.126.905 total
includes taxes & fees
16 Aug - 17 Aug
The Mermaid & Alligator

4. The Gardens Hotel

The Gardens Hotel
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Salvatore
Rp3.589.823
Rp4.038.529 total
includes taxes & fees
14 Sept - 15 Sept
The Gardens Hotel

5. The Marquesa Hotel

The Marquesa Hotel
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
Darrell
Rp4.028.189
Rp5.534.570 total
includes taxes & fees
10 Sept - 11 Sept
The Marquesa Hotel

6. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
United States
Jaime
Rp3.513.702
Rp4.676.022 total
includes taxes & fees
1 Sept - 2 Sept
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

7. Duval House

Duval House
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Melissa
Rp1.943.143
Rp2.569.318 total
includes taxes & fees
30 Aug - 31 Aug
Duval House

8. Island City House Hotel

Island City House Hotel
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
United States
Amelia
Rp3.055.191
Rp3.437.090 total
includes taxes & fees
16 Aug - 17 Aug
Island City House Hotel

9. The Grand Guesthouse

The Grand Guesthouse
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
United States
Travis
Rp2.660.887
Rp3.439.173 total
includes taxes & fees
19 Aug - 20 Aug
The Grand Guesthouse

10. Douglas House - Adults Only

Douglas House - Adults Only
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
United Kingdom
Dylan
Rp1.541.146
Rp1.907.169 total
includes taxes & fees
25 Aug - 26 Aug
Douglas House - Adults Only

11. Santa Maria Suites

Santa Maria Suites
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
United States
Nila
Rp4.987.683
Rp6.817.842 total
includes taxes & fees
23 Aug - 24 Aug
Santa Maria Suites

12. Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
United States
Patrice
Rp1.426.585
Rp2.811.695 total
includes taxes & fees
16 Aug - 17 Aug
Silver Palms Inn & Historic Homes

13. Weatherstation Inn

Weatherstation Inn
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
United States
Sheldon L
Rp3.191.033
Rp3.589.912 total
includes taxes & fees
25 Aug - 26 Aug
Weatherstation Inn

14. Coco Plum Inn

Coco Plum Inn
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
United States
Jake
Rp2.672.254
Rp3.006.196 total
includes taxes & fees
17 Aug - 18 Aug
Coco Plum Inn

15. Westwinds Inn

Westwinds Inn
Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary
United States
Karen
Rp2.369.149
Rp2.665.293 total
includes taxes & fees
19 Aug - 20 Aug
Westwinds Inn

16. Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
United States
Mark
Rp2.483.301
Rp5.049.944 total
includes taxes & fees
30 Aug - 31 Aug
Southernmost House - Adult Exclusive

17. Ambrosia Key West

Ambrosia Key West
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
Jenina
Rp3.370.194
Rp3.791.468 total
includes taxes & fees
16 Aug - 17 Aug
Ambrosia Key West

18. Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
Karri
Rp3.932.940
Rp5.329.671 total
includes taxes & fees
16 Aug - 17 Aug
Ella's Cottages - Key West Historic Inns

19. Marrero's Guest Mansion

Marrero's Guest Mansion
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
United States
Dane
Rp3.904.113
Rp4.392.216 total
includes taxes & fees
16 Aug - 17 Aug
Marrero's Guest Mansion

20. Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
ORLANDO
Rp1.800.472
Rp2.829.817 total
includes taxes & fees
25 Aug - 26 Aug
Paradise Inn Key West - Adults Only
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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Almond Tree Inn Hotel - Adults Only
10.0
Exceptional
1,016 reviews
View
Property grounds
Orchid Key Inn - Adults Only
9.8
Exceptional
1,010 reviews
View
Audubon Room - Adult Exclusive | Terrace/patio
The Mermaid & Alligator
9.8
Exceptional
312 reviews
View
Exterior detail
The Gardens Hotel
9.8
Exceptional
1,003 reviews
View
Exterior
The Marquesa Hotel
9.8
Exceptional
1,007 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

10/10 Excellent
"Beautiful property."
Jeff 1-night trip
Posted 1 hour ago
Hyatt Centric Key West Resort and Spa
Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

8/10 Good
"AWSOME FOOD AT RESTAURANTS GREAT SERVICE"
Patrice 3-night trip
Posted 4 hours ago
Opal Key Resort & Marina, Key West
Lighthouse Hotel - Key West Historic Inns

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent
"I’ve stayed here before and it’s very relaxing in the cottage style hotel. Love the air conditioning bar and morning breakfast."
Janice 4-night trip
Posted 4 hours ago
Lighthouse Hotel - Key West Historic Inns
Pier House Resort & Spa

Pier House Resort & Spa

10/10 Excellent
"Beautiful beach, helpful staff"
Cynthia 2-night trip
Posted 5 hours ago
Pier House Resort & Spa
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

8/10 Good
"Older resort but still nice, clean. The sargassum was in full force and the smell was very unpleasant but not the resorts fault. Amenities provided were nice. Pool area bars close way to early, adult only pool doesn’t have drinks available without walking. To neighboring pool. Close to sightseeing areas, shopping and dining options."
Heath 4-night trip
Posted 6 hours ago
Southernmost Beach Resort and Guesthouses
Southwinds Motel

Southwinds Motel

8/10 Good
"Love this property. Second time staying here. Quaint, nothing fancy but wonderful staff and great location."
Tracy 4-night trip
Posted 10 hours ago
Southwinds Motel
The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

8/10 Good
"The location is great, it’s very close to most things and only a few minute walk to either end of Duval St. The property is nice, and perfect for my wife and I. we’ve been going to Key West for over 20 years and prefer the authentic Key West Inns vs more corporate properties. We stayed in a loft suite which was fine but had a few broken things which were non-issues for us, but might bug someone"
David 4-night trip
Posted 1 day ago
The Cabana Inn Key West - Adults Only
Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only

10/10 Excellent
"Staff was amazing!"
Jeffrey Scott 5-night trip
Posted 1 day ago
Orchid Key Inn - Adults Only
Douglas House - Adults Only

Douglas House - Adults Only

10/10 Excellent
"Was nice and quiet"
Elizabeth 2-night trip
Posted 1 day ago
Douglas House - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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A wooden signpost with directional arrows pointing to various cities and their distances.
Photo by Martin Pettersson

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)
You can learn about the history of Key West with a trip to Jackson Square. Stroll along the beautiful beaches or discover the area's beautiful sunsets.
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Coffee Butler Amphitheater

You can make plans for a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its great live music.
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USCGC Ingham Maritime Museum

You can spend an afternoon browsing the exhibits at USCGC Ingham Maritime Museum during your trip to Key West.
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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its great live music.
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We Cycle Key West

You can do some window-shopping at We Cycle Key West during your stay in Key West.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1486 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1486 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Coffee Butler Amphitheater and Key West Film Society if you're interested in local theatre.