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Top Trending Hotels Near Mississippi River

Interior
The Eagles Nest Inn

The Eagles Nest Inn

3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"The room was great. Large and attractive!! Nice bathroom. Had all the convenience you need from TV to mini frig. "
United States
Judith
The price is Rp1.592.354
Rp1.807.919 total
includes taxes & fees
6 Dec - 7 Dec
The Eagles Nest Inn
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1002)
"great stay!"
United States
Guy
The price is Rp1.684.451
Rp1.951.436 total
includes taxes & fees
2 Jan - 3 Jan 2026
Sleep Inn & Suites Hannibal West
Balcony
River's Edge Motel

River's Edge Motel

2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (354)
"Staff was really nice and helpful."
United States
rhonda
The price is Rp1.332.240
Rp1.512.592 total
includes taxes & fees
11 Dec - 12 Dec
River's Edge Motel
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (164)
"Great place to stay!"
United States
Sandy
The price is Rp2.455.369
Rp3.393.770 total
includes taxes & fees
6 Dec - 7 Dec
Riverside Inn Hannibal
Deluxe Room | Down duvets, blackout curtains, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is Rp2.807.770
Rp3.224.724 total
includes taxes & fees
16 Dec - 17 Dec
Lighthouse Inn & Suites
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers
Best Western On The River

Best Western On The River

2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1002)
"The staff were friendly and very helpful and the room was clean and comfortable."
United States
Todd
The price is Rp1.679.262
Rp1.928.682 total
includes taxes & fees
7 Dec - 8 Dec
Best Western On The River
Classic Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Town & Country Inn and Suites

Town & Country Inn and Suites

2.5 star property
45.2 km from Mississippi River
9.2 out of 10, Wonderful, (891)
"Staff extremely helpful and kind"
United States
Sandra
Town & Country Inn and Suites
Indoor spa tub
Stoney Creek Inn Quincy

Stoney Creek Inn Quincy

2.0 star property
46.5 km from Mississippi River
8.8 out of 10, Excellent, (1001)
"Always love staying here"
United States
Ashlynn
Stoney Creek Inn Quincy
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (601)
"Overall very nice property. "
United States
Jeffrey
The price is Rp1.915.095
Rp2.182.824 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Quincy East by IHG
Family Suite, Multiple Beds | Premium bedding, desk, laptop workspace, iron/ironing board
Heritage Hotel Quincy

Heritage Hotel Quincy

2.0 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (267)
"Room was very clean Breakfast was satisfying "
United States
Mark
The price is Rp1.416.338
Rp1.614.342 total
includes taxes & fees
20 Dec - 21 Dec
Heritage Hotel Quincy
Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi
Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown

2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (446)
"It was in a very quite area and easy to find places to est. able to explore the Mississippi river. "
United States
James
The price is Rp1.769.381
Rp2.016.740 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn & Suites Quincy - Downtown
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1021)
"Very nice place to stay during a snow storm. "
United States
Teresa
The price is Rp1.322.748
Rp1.532.403 total
includes taxes & fees
2 Jan - 3 Jan 2026
Quality Inn & Suites Hannibal West
Lobby
Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy

2.5 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (334)
"hotel room was clean and staff is very friendly."
United States
Amee
The price is Rp1.826.001
Rp2.081.276 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites Quincy
Indoor pool, pool loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (659)
"The beds were super comfy"
United States
Jayme
The price is Rp1.344.730
Rp1.594.383 total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites - Hannibal
Bar (on property)
Oak Hill Inn & Suites

Oak Hill Inn & Suites

2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (861)
"Great place to stay when visiting Culver-Stockton college!"
United States
Kevin
The price is Rp1.750.779
Rp1.995.449 total
includes taxes & fees
6 Dec - 7 Dec
Oak Hill Inn & Suites
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1000)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is Rp964.258
Rp1.107.425 total
includes taxes & fees
20 Dec - 21 Dec
Motel 6 Hannibal, MO
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (214)
"Left before breakfast great cup of coffee"
United States
David
The price is Rp1.077.494
Rp1.237.502 total
includes taxes & fees
21 Dec - 22 Dec
Days Inn by Wyndham Hannibal
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 star property
93.4 km from Mississippi River
9.8 out of 10, Exceptional, (15)
"Very nice:) "
United States
Alicia
The price is Rp1.230.472
Rp1.414.428 total
includes taxes & fees
15 Dec - 16 Dec
WoodSpring Suites St Peters-OFallon
Exterior
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1000)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is Rp1.080.820
Rp1.241.320 total
includes taxes & fees
8 Dec - 9 Dec
Super 8 by Wyndham Hannibal
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
86.2 km from Mississippi River
9.4 out of 10, Exceptional, (832)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is Rp1.718.590
Rp2.067.377 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mississippi River Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Very nice rodeo suite. I would recommend."
Jon 1-night trip
Posted 4 days ago
Hollywood Casino & Hotel St. Louis

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savour the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Pear Tree Inn St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. You'll find it 69.9 mi (112.5 km) from Mississippi River. Other good options around the area include Magnolia Hotel St. Louis, a Tribute Portfolio Hotel and Hyatt Regency St. Louis at The Arch.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.

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