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Check prices for these dates

Tonight
23 Oct - 24 Oct
Tomorrow
24 Oct - 25 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for Mississippi River hotels

A staircase with wooden steps and a wooden handrail, leading up a brick wall.
A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.
A row of multi-story buildings with a variety of storefronts, including a coffee shop and a restaurant.
A downtown area with a mix of historic and modern buildings, a prominent Mercantile Bank, and a view of a lake.

1. The Eagles Nest Inn

The Eagles Nest Inn
14.2 km from Mississippi River
United States
Kimberly
Rp2.108.575
Rp2.394.024 total
includes taxes & fees
1 Nov - 2 Nov
The Eagles Nest Inn
A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.
A hotel room with a desk, a television, a chair, a small refrigerator, a lamp, and a plant.
A gazebo with a table and benches, surrounded by trees and a body of water.
A two-story building with a flat roof and a covered entrance. There are two cars parked in front, and a truck is visible on the left.

2. River's Edge Motel

River's Edge Motel
13.6 km from Mississippi River
United States
Joseph
Rp1.495.826
Rp1.698.393 total
includes taxes & fees
24 Oct - 25 Oct
River's Edge Motel
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.
A hotel kitchen with a buffet setup, including a coffee station and various food items.
A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

3. Best Western On The River

Best Western On The River
25.3 km from Mississippi River
United States
Wei
Rp1.986.419
Rp2.291.334 total
includes taxes & fees
25 Oct - 26 Oct
Best Western On The River
A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.
A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.
A modern lobby with a brown sofa, beige armchairs, a round table, and a floor lamp.
An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

4. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
30.3 km from Mississippi River
United States
Steve
Rp2.090.806
Rp2.432.654 total
includes taxes & fees
23 Nov - 24 Nov
Sleep Inn & Suites Hannibal West
A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.
A wooden table with a bottle of champagne, two glasses, and scattered rose petals.
A compact kitchen with a refrigerator, microwave, and sink.
A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

5. Riverside Inn Hannibal

Riverside Inn Hannibal
25.1 km from Mississippi River
United States
Christina
Rp2.712.973
Rp3.754.493 total
includes taxes & fees
26 Oct - 27 Oct
Riverside Inn Hannibal
A hotel room with a bed, desk, chair, and a bathroom with a bathtub.
A lobby with leather sofas, a fireplace, a flat-screen TV, and a reception desk.
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.
A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

6. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
30 km from Mississippi River
United States
Gayle
Rp1.338.607
Rp1.557.470 total
includes taxes & fees
15 Nov - 16 Nov
Quality Inn & Suites Hannibal West
A lobby with a reception desk, seating area, and a staircase.
A compact living space with a kitchenette, a sofa, a patterned armchair, and a television.
A compact living space with a dining table, two chairs, a sofa, a desk, and a kitchenette.
Room

7. Heritage Hotel Quincy

Heritage Hotel Quincy
47.8 km from Mississippi River
United States
Amy
Rp1.406.513
Rp1.603.186 total
includes taxes & fees
1 Nov - 2 Nov
Heritage Hotel Quincy
A hotel room with a large bed, two bedside lamps, a nightstand with a phone, a mirror, and a bathtub.
A hotel room with a bathtub, two yellow armchairs, a desk with a chair, a small table, and a lamp.
A hotel room with a sofa, armchair, small table, TV, dresser, and a bathtub.
A bar area with a long counter, multiple bottles, glasses, and a few chairs.

8. Oak Hill Inn & Suites

Oak Hill Inn & Suites
71.8 km from Mississippi River
United States
Regina
Rp1.824.566
Rp2.079.549 total
includes taxes & fees
1 Nov - 2 Nov
Oak Hill Inn & Suites
A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.
A hotel room with two beds, a window with red curtains, an air conditioning unit, and two bedside lamps.
A coffee station with a coffee machine, cups, and a sign that says "RISE & SHINE."
A spacious lobby with a fireplace, leather sofas, a coffee table, and a large window with blinds.

9. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
26.1 km from Mississippi River
United States
Jared
Rp1.047.299
Rp1.208.033 total
includes taxes & fees
26 Oct - 27 Oct
Motel 6 Hannibal, MO
A row of single-family homes with a well-maintained lawn and a tree in the foreground.
A living room with a sofa, a patterned armchair, a dining table with chairs, a kitchen area with wooden cabinets and a refrigerator, and a television on a stand.
A compact kitchen with wooden cabinets, a microwave, a coffee maker, and a dishwasher.
A modern kitchen with wooden cabinets, a white countertop, and a dining area with a white table and chairs.

10. Nauvoo Vacation Villas & Condos

Nauvoo Vacation Villas & Condos
112.1 km from Mississippi River
United States
Renae
Rp2.595.168
Rp2.750.337 total
includes taxes & fees
30 Oct - 31 Oct
Nauvoo Vacation Villas & Condos
A hotel room with a bed, a sofa, a desk, and a lamp.
A Comfort Inn & Suites hotel with a stone facade, a covered entrance, and a clear blue sky.
An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.
A restaurant with multiple tables and chairs, an exit sign, and a counter area.

11. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
26.2 km from Mississippi River
United States
Jerry
Rp1.416.626
Rp1.688.258 total
includes taxes & fees
15 Nov - 16 Nov
Comfort Inn & Suites - Hannibal
A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.
A spacious lobby with a fireplace, seating area, and large windows.
A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.
An outdoor patio with tables and chairs, green umbrellas, and string lights.

12. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
46.1 km from Mississippi River
United States
Colleen
Rp2.004.660
Rp2.284.912 total
includes taxes & fees
22 Nov - 23 Nov
Holiday Inn Quincy East by IHG
A hot tub with a rocky backdrop and a mural.
A restaurant with wooden walls, a bar area, and multiple seating arrangements.
An indoor swimming pool with a 'No Diving' sign, lounge chairs, and a mural on the wall.
A cozy log cabin interior with a fireplace, wooden furniture, and a television mounted on the wall.

13. Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
46.5 km from Mississippi River
United States
Kent
Rp1.760.497
Rp2.006.615 total
includes taxes & fees
1 Nov - 2 Nov
Stoney Creek Inn Quincy
A hotel room with a large bed, a desk, a chair, a desk lamp, a wall-mounted phone, and a window with curtains.
A laundry room with a washing machine, dryer, and a shelf with detergent bottles.
A hotel room with a dining area, kitchenette, and a door leading to a hallway.
A hotel with a covered entrance, a parking lot, and a clear sky.

14. Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
26.4 km from Mississippi River
United States
Christian
Rp1.074.570
Rp1.239.515 total
includes taxes & fees
3 Nov - 4 Nov
Days Inn by Wyndham Hannibal
A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.
A hotel room with a large bed, a desk with a chair, a window with curtains, and a wall-mounted artwork.
A modern dining area with round tables and chairs, a flat-screen TV mounted on the wall, and a brick accent wall.
A patio with red Adirondack chairs and a table, surrounded by a pebble border.

15. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
26.3 km from Mississippi River
United States
Julie
Rp1.115.205
Rp1.286.390 total
includes taxes & fees
25 Oct - 26 Oct
Super 8 by Wyndham Hannibal
A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.
A reception area with a reception desk, seating area with chairs, a patterned rug, and a large window with a view of the outside.
A hotel entrance with a sign reading "Quality Inn & Suites by Choice Hotels".
A modern kitchen with dark cabinets, a central island with bar stools, and pendant lighting.

16. Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
47.8 km from Mississippi River
United States
Bryan
Rp2.089.361
Rp2.381.454 total
includes taxes & fees
22 Nov - 23 Nov
Quality Inn & Suites Quincy - Downtown
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.
A swimming pool with lounge chairs and a covered seating area.
A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.
A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

17. Lighthouse Inn & Suites

Lighthouse Inn & Suites
25.8 km from Mississippi River
United States
Connie
Rp2.817.541
Rp3.875.134 total
includes taxes & fees
24 Oct - 25 Oct
Lighthouse Inn & Suites
A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.
A modern building with a red awning, a parking lot, and a sign indicating an entrance.
A kitchen with wooden cabinets, a granite countertop, and various food items and kitchen appliances.
A hotel room with two beds, a desk, a chair, and a telephone.

18. Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
26.3 km from Mississippi River
United States
Debbie
Rp1.056.510
Rp1.226.873 total
includes taxes & fees
1 Nov - 2 Nov
Howard Johnson BY Wyndham Hannibal
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.
A modern building with a flat roof, large windows, and a covered entrance area.
A modern bathroom with a marble sink, a large mirror, and a framed picture on the wall.
A coffee shop display with a white cup, two Starbucks branded bags, and a branded coffee grinder.

19. DoubleTree by Hilton Quincy

DoubleTree by Hilton Quincy
47.9 km from Mississippi River
United States
Ronda
Rp2.043.670
Rp2.329.375 total
includes taxes & fees
1 Nov - 2 Nov
DoubleTree by Hilton Quincy
A large indoor swimming pool with a lifeguard chair, poolside chairs, and a view of the outside through large windows.
A reception desk with a "Welcome to the Hawk Eye State" sign, a digital kiosk, and a "Manager On Duty" sign.
A breakfast buffet area with a sign reading "EAT HERE" and various food items like cereal and pastries.
A Hampton Inn hotel with a covered entrance, a well-lit facade, and a landscaped front yard.

20. Hampton Inn Keokuk

Hampton Inn Keokuk
98.9 km from Mississippi River
United States
Kristopher
Rp1.826.769
Rp2.045.980 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Keokuk
View all properties

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A staircase with wooden steps and a wooden handrail, leading up a brick wall.
The Eagles Nest Inn
9.6
Exceptional
27 reviews
View
A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.
River's Edge Motel
9.0
Wonderful
393 reviews
View
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River
8.8
Excellent
1,003 reviews
View
A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.
Sleep Inn & Suites Hannibal West
9.6
Exceptional
1,002 reviews
View
A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.
Riverside Inn Hannibal
9.6
Exceptional
203 reviews
View

Top Mississippi River Hotel Reviews

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent
"Family friendly helpful polite Cheerful. I truefully don’t have all the words to how amazing this stay was."
Garrett 2-night trip
Posted 1 hour ago
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Good"
Lyle 3-night trip
Posted 1 hour ago
Drury Plaza Hotel St. Louis Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Very nice property with good breakfast."
Greg 2-night trip
Posted 4 hours ago
Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Everything was Great - Will stay there again"
Judy 1-night trip
Posted 4 hours ago
Drury Plaza Hotel St. Louis at the Arch
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"We enjoyed the fresh popcorn and it was within walking distance from the train station."
Tamela 1-night trip
Posted 19 hours ago
Pear Tree Inn St. Louis Near Union Station
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

10/10 Excellent
"The hotel was in a great location close to restaurants and shopping, and seemed like a very safe area. The beds were very comfortable!"
Teresa 3-night trip
Posted 1 day ago
Hampton Inn St. Charles St. Peters
Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"Great place to stay."
brandon 1-night trip
Posted 5 days ago
Live by Loews - St.Louis

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savour the top-notch restaurants.
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Sawyer's Creek Fun Park

7.8/10 (16 reviews)
Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savour the top-notch restaurants.
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Lovers Leap

8.8/10 (171 reviews)
Find out about the history of Hannibal when you spend time at Lovers Leap. While in this walkable area, you can savour the top-notch restaurants.
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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
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Bluff City Theater

7.6/10 (5 reviews)
Get tickets for a show at Bluff City Theater, a theatre with a story to tell in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
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Planters Barn Theater

8.8/10 (22 reviews)
Get tickets for a show at Planters Barn Theater, a popular theatre in Hannibal. While in this walkable area, you can savour the top-notch restaurants.
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Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)
Find out about the history of Hannibal with a stop at Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savour the top-notch restaurants.
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Jim's Journey: The Huck Finn Freedom Center

8.4/10 (33 reviews)
You can browse the exhibits at Jim's Journey: The Huck Finn Freedom Center, a museum with a story of its own, during your holiday in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
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Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.