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Check prices for these dates

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8 Mar - 9 Mar
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9 Mar - 10 Mar
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13 Mar - 15 Mar
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20 Mar - 22 Mar

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Our top choices for Mississippi River hotels

Property grounds

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (360 reviews)
"Staff was really nice and helpful."
United States
rhonda
The price is Rp1.354.000
Rp1.537.298 total
includes taxes & fees
9 Mar - 10 Mar
River's Edge Motel
Interior

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (21 reviews)
"Room was spacious and clean. Had a great stay. The restaurant was delicious. "
United States
James
The price is Rp1.929.450
Rp2.190.649 total
includes taxes & fees
9 Mar - 10 Mar
The Eagles Nest Inn
Indoor pool

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (743 reviews)
"Thanks to the staff very help and kind. Very good stay. "
United States
Terry
The price is Rp1.066.275
Rp1.232.880 total
includes taxes & fees
11 Mar - 12 Mar
Baymont by Wyndham Hannibal
Desk, iron/ironing board, WiFi, bed sheets

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1,012 reviews)
"Everything was great. Will definitely stay again."
United States
Ethan
The price is Rp1.191.385
Rp1.368.305 total
includes taxes & fees
10 Mar - 11 Mar
Best Western On The River
Honeymoon Room, River View | Egyptian cotton sheets, premium bedding, pillow-top beds

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (168 reviews)
"Great place to stay!"
United States
Sandy
The price is Rp2.408.010
Rp3.348.750 total
includes taxes & fees
9 Mar - 10 Mar
Riverside Inn Hannibal
Lobby

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,004 reviews)
"It was a good midway stop for us on our way to Memphis."
United States
Joel
The price is Rp1.855.826
Rp2.149.974 total
includes taxes & fees
29 Mar - 30 Mar
Sleep Inn & Suites Hannibal West
Room, Accessible | Desk, iron/ironing board, free WiFi, bed sheets

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
90.7 km from Mississippi River
6.8 out of 10, (1,001 reviews)
"Staff was awesome and accomodating. Room and price was great. "
United States
Anthony
The price is Rp1.194.059
Rp1.408.392 total
includes taxes & fees
15 Mar - 16 Mar
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Interior

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (520 reviews)
"Great value"
United States
Josh
The price is Rp1.015.500
Rp1.152.085 total
includes taxes & fees
9 Mar - 10 Mar
Economy Inn Wentzville
Down duvets, blackout curtains, iron/ironing board, free WiFi

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (25 reviews)
"Nice room. Matched the pictures. Exactly what we were looking for."
United States
John
The price is Rp2.857.922
Rp3.282.323 total
includes taxes & fees
9 Mar - 10 Mar
Lighthouse Inn & Suites
In-room safe, desk, blackout curtains, iron/ironing board

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (678 reviews)
"Everything was clean and staff was friendly. Just needed some updates. "
United States
Georgia
The price is Rp1.335.721
Rp1.584.849 total
includes taxes & fees
29 Mar - 30 Mar
Comfort Inn & Suites - Hannibal
Cleanliness standards

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
98 km from Mississippi River
6.8 out of 10, (1,006 reviews)
"Clean room very nice staff it’s nice"
United States
Mercedez
The price is Rp1.066.275
Rp1.225.370 total
includes taxes & fees
9 Mar - 10 Mar
Relax Inn Saint Charles
TV

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.4 out of 10, Very good, (39 reviews)
"Great location. Clean rooms, Staff very friendly."
United States
Charles
The price is Rp1.812.668
Rp2.081.944 total
includes taxes & fees
10 Mar - 11 Mar
Garden House Bed and Breakfast
Lobby

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1,014 reviews)
"Good breakfast selections. Close to a good restaurant. "
United States
Steve
The price is Rp1.353.492
Rp1.568.020 total
includes taxes & fees
5 Apr - 6 Apr
Quality Inn & Suites Hannibal West
Lobby sitting area

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1,002 reviews)
"Overall, very nice stay"
United States
Cary
The price is Rp930.706
Rp1.068.814 total
includes taxes & fees
11 Mar - 12 Mar
Motel 6 Hannibal, MO
Lobby

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
93.8 km from Mississippi River
6.2 out of 10, (1,006 reviews)
"Room was excellent and clean"
United States
catherine
The price is Rp1.179.673
Rp1.356.034 total
includes taxes & fees
10 Mar - 11 Mar
Days Inn by Wyndham St Peters/St Charles
Free daily on-the-go breakfast

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk
2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (498 reviews)
"Great location for geode hunting. Irish Pub behind the hotel is the best."
United States
Marty
The price is Rp1.111.972
Rp1.245.409 total
includes taxes & fees
22 Mar - 23 Mar
Baymont by Wyndham Keokuk
Exterior

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1,001 reviews)
"clean room - soft beds - friendly staff - very welcoming - lobby nice"
United States
Maxine
The price is Rp1.015.500
Rp1.166.471 total
includes taxes & fees
22 Mar - 23 Mar
Super 8 by Wyndham Hannibal
Exterior

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
89.4 km from Mississippi River
5.6 out of 10, (36 reviews)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is Rp1.142.437
Rp1.290.383 total
includes taxes & fees
9 Mar - 10 Mar
LAKEVIEWINN
Indoor pool

Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (156 reviews)
"Yes my stay was great"
United States
Aaron
The price is Rp964.725
Rp1.115.463 total
includes taxes & fees
11 Mar - 12 Mar
Howard Johnson BY Wyndham Hannibal
Reception

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
3.0 star property
109.6 km from Mississippi River
6.6 out of 10, (1,007 reviews)
"Great staff and the place is nice and clean and the breakfast is awesome."
United States
Kerry
The price is Rp1.222.831
Rp1.494.764 total
includes taxes & fees
10 Mar - 11 Mar
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mississippi River Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Shower with select a temp the best! Free breakfast was great! Only bummer was $10 to park!"
alan 1-night trip
Posted 2 hours ago
Clayton Plaza Hotel & Extended Stay

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savour the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this trendy area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Pear Tree Inn St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. You'll find it 69.9 mi (112.5 km) from Mississippi River. Other good options around the area include Pear Tree Inn St. Louis Near Union Station and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.