Lodging Image

Southeast Missouri Hotel Guide - 4 Stars Hotels in Southeast Missouri, Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri 4 Star Hotels

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for Southeast Missouri 4-star hotels

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

1. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (695 reviews)
"Clean, quiet, comfortable room. Very comfortable beds."
United States
Renee
The price is Rp2.066.544
Rp2.331.351 total
includes taxes & fees
28 Oct - 29 Oct
The Riverview
Street view

2. Urban Lofts

Urban Lofts
4.0 star property
Perryville
Urban Lofts
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

The Riverview

The Riverview

10/10 Excellent
"Nice hotel directly on the river just a short walk from downtown Cape Girardeau. Staff was friendly, professional and knowledgeable. Rooms were spacious with views of the river."
Gregory 1-night trip
Posted 2 hours ago
The Riverview

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
We can help you quickly locate the ideal 4-star hotel for your trip to Southeast Missouri. Use our filter tool to fine-tune your search by things like budget, conveniences and property star rating and get access to unbeatable deals in a couple of clicks.

  • Search for the lowest price from Rp2.331.351

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Offering a welcoming traveller experience and upmarket surroundings, 4-star hotels are a fantastic option for your Southeast Missouri holiday. These kinds of accommodation generally come with loads of useful amenities that make it simple to kick back and relax — think large beds, bathrobes, gyms and restaurants. Or live in the lap of luxury at a 5-star hotel designed to spoil you with exclusive perks and amenities. 24-hour front desk, oversized bathrooms and fine dining are typically featured at these plush properties.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to search for your next dream escape in Southeast Missouri where everything is taken care of, from your meals to your room, entertainment and activities. We can also help you find standard 4-star stays in and around this popular destination.