Southeast Missouri Holiday Rentals, Missouri: Private House Rentals

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A building with a red awning labeled "Shepherd Mountain Inn."

A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Ironton

Michael

Rp2.216.687

Rp2.421.277 total

includes taxes & fees

1 Oct - 2 Oct

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

2. Madison Inn Lodge

Fredericktown

Bawan

Rp1.573.255

Rp1.718.517 total

includes taxes & fees

12 Oct - 13 Oct

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A hotel lobby with a seating area, a reception desk, and a bar.

A swimming pool with a diving board, pool rules signs, and lounge chairs.

A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

3. Holiday Inn Express & Suites Perryville by IHG

Perryville

David

Rp1.852.043

Rp2.120.126 total

includes taxes & fees

31 Oct - 1 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

4. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Vicki

Rp1.818.475

Rp2.054.421 total

includes taxes & fees

8 Oct - 9 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

An outdoor pool area with lounge chairs and an umbrella.

5. Fort Davidson Hotel

Ironton

richard

Rp2.157.720

Rp2.356.770 total

includes taxes & fees

27 Oct - 28 Oct

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

6. Hampton Inn & Suites By Hilton Festus

Festus

Abram

Rp1.606.874

Rp1.837.460 total

includes taxes & fees

15 Oct - 16 Oct

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

7. Super 8 by Wyndham Farmington

Farmington

Marisa

Rp1.069.870

Rp1.164.553 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

8. Drury Inn & Suites Jackson MO

Jackson

Thomas

Rp1.509.972

Rp1.596.418 total

includes taxes & fees

12 Oct - 13 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

9. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

Rp1.818.475

Rp2.051.495 total

includes taxes & fees

15 Oct - 16 Oct

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

10. Crown Pointe Lodge, BW Signature Collection

Farmington

Stephanie

Rp1.971.617

Rp2.146.105 total

includes taxes & fees

1 Oct - 2 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

11. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

Rp1.797.620

Rp2.027.968 total

includes taxes & fees

5 Oct - 6 Oct

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

A hotel room with two beds, a nightstand, a lamp, and a chair.

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

Rp1.512.849

Rp1.637.281 total

includes taxes & fees

4 Oct - 5 Oct

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

A reception desk with a modern design, a digital screen, and a sign indicating 'IHG' branding.

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

A hotel room with a bed, a desk, a microwave, a coffee maker, and a TV mounted on the wall.

13. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Steven

Rp1.977.910

Rp2.261.741 total

includes taxes & fees

25 Oct - 26 Oct

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

14. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

Rp1.635.099

Rp1.830.902 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

15. The Riverview

Cape Girardeau

Alyssa

Rp2.054.885

Rp2.318.197 total

includes taxes & fees

7 Oct - 8 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

16. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Joseph

Rp1.021.321

Rp1.111.708 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

17. Super 8 by Wyndham Perryville

Perryville

paulette

Rp1.283.629

Rp1.469.434 total

includes taxes & fees

6 Oct - 7 Oct

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

An indoor swimming pool with multiple lanes, surrounded by seating areas and tables.

Two grey armchairs with green cushions, a small side table with a white lamp, and wall-mounted sconces.

A hotel room with a brick wall, two beds, a desk with a TV, and a patterned carpet.

18. Drury Inn & Suites Hayti Caruthersville

Hayti

Philip

Rp1.833.882

Rp2.090.167 total

includes taxes & fees

11 Oct - 12 Oct

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

A hotel room with a large bed, a bedside table with a lamp, a vanity with a mirror, and a wall with framed pictures.

A modern hotel with a prominent 'La Quinta' sign, large windows, and a well-lit entrance.

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

19. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Lisa-Marie

Rp1.818.475

Rp2.079.425 total

includes taxes & fees

2 Oct - 3 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

20. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

Rp1.815.778

Rp2.055.914 total

includes taxes & fees

18 Oct - 19 Oct

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Holiday Rentals in Southeast Missouri

Cabin

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A rustic cabin with a wooden exterior, a small deck, and a picnic table.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A hallway with exposed brick walls, wooden flooring, and a white door.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

A covered porch with yellow chairs, a bench, and a small table.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

8/10 Good

"pretty good value for the price"

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"This hotel is in a great location just off the US 67 expressway! Easy to get in and out of the parking lot. We were 10 minutes south of the business district on either side of Walmart. Take the first left. The staff was very friendly and helpful going so far as to changing our room to the 1st floor because there wasn’t an elevator for my oxygen machine because there’s only 2 stories. Breakfast was the usual hot food buffet including the waffle maker! The AC was set to 60. We turned it up to 70 because it wasn’t that hot outside. This was a very nice basic hotel with suites."

Drury Inn & Suites Hayti Caruthersville

8/10 Good

"At breakfast they ran out of milk! And no coffee creamer except the powdered nondairy packet stuff."

Hampton Inn Poplar Bluff

10/10 Excellent

"Everything was clean and neat. Staff was very helpful, Beds were very comfortable."

Holiday Inn Poplar Bluff by IHG

10/10 Excellent

"Room was really good size. We got fresh hot breakfast for free. We had dinner at the restaurant and it was priced reasonably and portions were big. Hotel was maintained well. Staff was very friendly and helpful. Staff at the restaurant were also friendly and polite."

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"trodo estubo excelente gracias por sus servicios"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"The room was very clean and the bed was very comfortable. The parking around the hotel was ample and the amenities were great. So many stores and restaurants within walking distance. The breakfast was the best with home cooked eggs and gravy."

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Clean rooms. Nice breakfast. Very nice staff."

Comfort Inn Festus - St Louis South

10/10 Excellent

"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Rp1.021.321

Rp1.111.708 total

25 Oct - 26 Oct

includes taxes & fees

8/10 Very good! (1,001 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Rp1.192.121

Rp1.358.719 total

7 Oct - 8 Oct

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Rp1.294.236

Rp1.460.080 total

11 Oct - 12 Oct

includes taxes & fees

9.2/10 Wonderful! (1,000 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

Rp1.280.247

Rp1.495.969 total

25 Oct - 26 Oct

includes taxes & fees

7.8/10 Good! (1,005 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Rp1.420.262

Rp1.590.514 total

15 Oct - 16 Oct

includes taxes & fees

8/10 Very good! (1,001 reviews)

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

Rp1.635.099

Rp1.830.902 total

18 Oct - 19 Oct

includes taxes & fees

9.4/10 Exceptional! (958 reviews)

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Book Hotels in Southeast Missouri on Expedia.com

Find hotels in Southeast Missouri, MO from Rp1.111.708

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Holiday Inn Express & Suites Perryville by IHG

4. Fairfield Inn & Suites by Marriott Poplar Bluff

5. Fort Davidson Hotel

6. Hampton Inn & Suites By Hilton Festus

7. Super 8 by Wyndham Farmington

8. Drury Inn & Suites Jackson MO

9. Fairfield Inn & Suites by Marriott Cape Girardeau

10. Crown Pointe Lodge, BW Signature Collection

11. Drury Plaza Hotel Cape Girardeau Conference Center

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

13. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

14. Hampton Inn Poplar Bluff

15. The Riverview

16. Baymont Inn and Suites by Wyndham Farmington, MO

17. Super 8 by Wyndham Perryville

18. Drury Inn & Suites Hayti Caruthersville

19. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

20. Fairfield Inn & Suites by Marriott Sikeston

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

The Atrium - A Boutique Hotel

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Urban Lofts

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Hayti Caruthersville

Hampton Inn Poplar Bluff

Holiday Inn Poplar Bluff by IHG

Candlewood Suites Cape Girardeau by IHG

Pear Tree Inn Cape Girardeau West

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Comfort Inn Festus - St Louis South

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

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