Find the best Mississippi County Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Mississippi County Accommodation: Most Popular Cities to Stay

Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.
HotelsHotels

Charleston

Charleston
Bridge over Mississippi River, New Orleans in background
HotelsHotels

East Prairie

East Prairie

Check prices for these dates

Tonight
31 Jan - 1 Feb
Tomorrow
1 Feb - 2 Feb
Next weekend
6 Feb - 8 Feb
In two weeks
13 Feb - 15 Feb

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mississippi County hotels

Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (622 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is Rp1.042.411
Rp1.156.723 total
includes taxes & fees
1 Feb - 2 Feb
Super 8 by Wyndham Charleston/Sikeston East MO
Front of property

The Riverstone Hotel

The Riverstone Hotel
2.5 star property
Charleston
6.8 out of 10, (408 reviews)
"The staff was very friendly and accommodating "
United States
Arturo
The price is Rp1.175.020
Rp1.303.978 total
includes taxes & fees
1 Feb - 2 Feb
The Riverstone Hotel
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
"Middle of nowhere hotel was ok"
United States
David
The price is Rp1.070.779
Rp1.188.449 total
includes taxes & fees
19 Feb - 20 Feb
Eagle Inn Charleston
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (276 reviews)
"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6. I was not satisfied at all."
United States
ReShena
The price is Rp1.229.071
Rp1.364.023 total
includes taxes & fees
2 Mar - 3 Mar
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mississippi County Hotel Reviews

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

10/10 Excellent
"Clean room,friendly staff,free popcorn and soda for the kids.Very nice,attractive rooms."
sandra 1-night trip
Posted 6 days ago
Pear Tree Inn Sikeston

Explore a world of travel with Expedia