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Check prices for these dates

Tonight
12 Dec - 13 Dec
Tomorrow
13 Dec - 14 Dec
This weekend
12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Downtown hotels

Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (664)
"Friendly check in, clean room."
United States
connie
The price is Rp1.225.646
Rp1.447.515 total
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
3.1 km from Downtown
6.8 out of 10, (720)
"Room was clean. Quiet place to rest. Lisa at the front desk was very helpful and very nice. "
United States
Teresa
The price is Rp1.177.338
Rp1.295.072 total
includes taxes & fees
14 Dec - 15 Dec
Days Inn by Wyndham Seneca / Clemson Area
Terrace/patio
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
8.3 km from Downtown
9.2 out of 10, Wonderful, (791)
"Staff was very friendly. Everything was very clean. Very quite in room"
United States
Dianna
The price is Rp1.587.555
Rp1.746.310 total
includes taxes & fees
22 Dec - 23 Dec
Tru by Hilton Seneca Clemson
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
8.6 km from Downtown
9.0 out of 10, Wonderful, (1001)
"Great place to stay. "
United States
Gene
The price is Rp1.817.684
Rp2.256.430 total
includes taxes & fees
13 Dec - 14 Dec
Lakeside Lodge Clemson
Free breakfast
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
11.8 km from Downtown
8.2 out of 10, Very good, (1001)
" Clean room, breakfast, staff very nice."
United States
Maria Claudia
The price is Rp1.545.031
Rp1.714.985 total
includes taxes & fees
14 Dec - 15 Dec
Best Western Plus Clemson Hotel & Conference Center
Property amenity
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
2 km from Downtown
9.4 out of 10, Exceptional, (204)
"Nice hotel by the lake"
United States
Mike
The price is Rp1.917.740
Rp2.109.514 total
includes taxes & fees
28 Dec - 29 Dec
Fairfield Inn & Suites Seneca Clemson Univ Area
Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
11.7 km from Downtown
8.2 out of 10, Very good, (1000)
"Great stay "
United States
Linda
The price is Rp1.559.206
Rp1.730.718 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn & Suites Clemson - University Area
Exterior
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
7.5 km from Downtown
9.8 out of 10, Exceptional, (50)
"The place was absolutely magnificent."
United States
David
The price is Rp1.484.164
Rp2.366.324 total
includes taxes & fees
14 Dec - 15 Dec
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Lobby
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
10.6 km from Downtown
9.8 out of 10, Exceptional, (742)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is Rp2.818.244
Rp3.128.251 total
includes taxes & fees
14 Dec - 15 Dec
The Shepherd Hotel Downtown Clemson
Lobby
Quality Inn Clemson near University

Quality Inn Clemson near University

Quality Inn Clemson near University
2.5 star property
29.6 km from Downtown
7.0 out of 10, Good, (889)
"Bueno was "
Mexico
Alejandro
The price is Rp840.408
Rp932.852 total
includes taxes & fees
24 Dec - 25 Dec
Quality Inn Clemson near University
Front of property
Woodspring Suites Anderson North I-85

Woodspring Suites Anderson North I-85

Woodspring Suites Anderson North I-85
2.5 star property
25.4 km from Downtown
7.6 out of 10, Good, (59)
"Everything was perfect, the room was clean, and the staff was nice."
United States
Johnny
The price is Rp1.234.024
Rp1.369.767 total
includes taxes & fees
14 Dec - 15 Dec
Woodspring Suites Anderson North I-85
Reception
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
2.2 km from Downtown
9.2 out of 10, Wonderful, (662)
"Great place to stay"
United States
Jose
The price is Rp1.694.282
Rp1.863.543 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Seneca-Clemson Area
Business centre
Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson
2.5 star property
25 km from Downtown
7.0 out of 10, Good, (842)
"Well lit parking and safe area around the hotel"
United States
Gregory
The price is Rp992.936
Rp1.102.158 total
includes taxes & fees
12 Jan - 13 Jan 2026
Baymont by Wyndham Anderson Clemson
Golf
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
10.3 km from Downtown
9.6 out of 10, Exceptional, (960)
"Great place to stay!"
United States
Mindi
The price is Rp2.484.724
Rp2.758.044 total
includes taxes & fees
14 Dec - 15 Dec
Clemson University's James F. Martin Inn
Café
Courtyard Marriott Clemson

Courtyard Marriott Clemson

Courtyard Marriott Clemson
3.0 star property
12.9 km from Downtown
9.0 out of 10, Wonderful, (523)
"Great property "
United States
Shaun
The price is Rp1.786.000
Rp1.982.460 total
includes taxes & fees
22 Dec - 23 Dec
Courtyard Marriott Clemson
Free daily continental breakfast
Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
3.5 star property
12.5 km from Downtown
7.0 out of 10, Good, (197)
"Rooms were clean. Check in was easy. TV and AC both worked great. Conveniently located to dining and shopping options. No issues or complaints. Would stay again. "
United States
Sean
The price is Rp1.409.956
Rp1.565.051 total
includes taxes & fees
15 Dec - 16 Dec
Days Inn by Wyndham Clemson
Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
1.7 km from Downtown
8.4 out of 10, Very good, (641)
"The stay was amazing "
United States
Tabatha
The price is Rp1.488.333
Rp1.637.167 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Seneca-Clemson
Exterior
Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
2.5 star property
12.4 km from Downtown
8.8 out of 10, Excellent, (950)
"Had a great stay at this hotel. Conveniently located near restaurants. "
United States
Kelly
The price is Rp1.967.768
Rp2.184.220 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Clemson by IHG
Lobby
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
25.7 km from Downtown
9.0 out of 10, Wonderful, (674)
"Staff were great. Room was clean."
United States
gary
The price is Rp1.720.963
Rp1.910.269 total
includes taxes & fees
26 Dec - 27 Dec
Hilton Garden Inn Anderson
Lobby
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
24.8 km from Downtown
8.2 out of 10, Very good, (1000)
"Room was clean, staff was nice! "
United States
Martina
The price is Rp1.332.412
Rp1.478.978 total
includes taxes & fees
21 Dec - 22 Dec
Microtel Inn & Suites by Wyndham Anderson/Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown

Find the best Downtown areas for the activities you enjoy most.

Serenity Bay

When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.

Pine Ridge Point

If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit Lake Keowee and World of Energy.

Indian Oaks

While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like The Gauntlet and Seneca Historic District.

Keowee Plantation

While Keowee Plantation isn't home to many top sights, Seneca Historic District and Keowee Reservoir are some notable places to visit nearby.

Top Downtown Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What is Downtown like?
Travellers to the Downtown neighbourhood in Seneca will be sure to enjoy their stay. Make sure that you visit Seneca Historic District and Bertha Lee Strickland Cultural Museum as part of your Downtown travel plans.
Where is the best place to stay in Downtown?
Based on Expedia customer reviews, Quality Inn Seneca Clemson Area US-123 is the highest ranked property in Downtown. This hotel offers free breakfast and free parking.
How many hotels will I be able to find in Downtown?
Expedia has 9 Downtown hotels and other accommodation options, and one might make a good home base for venturing out into the greater Seneca area.
If I need to cancel my hotel reservation in Downtown, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals in Downtown.
What can I see and do in this Seneca neighbourhood?
Seneca Historic District, Bertha Lee Strickland Cultural Museum and Oconee County Library Seneca Branch are just a few attractions to check out in Downtown. As you're discovering the neighbourhood, The Gauntlet and Seneca City Hall are some other places worth a visit. Golden Corner Plaza, Oconee Community Theatre and Applewood Shopping Center are just a few of the places to visit in and around Downtown. While you're out sightseeing in Seneca, make sure that you visit other sights such as Wyndham Plaza or Cross Creek Plantation Golf.