Search Hotels in Downtown South San Francisco, San Francisco

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Our top choices for Downtown South San Francisco hotels

Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very good, (2015)
"Clean room, staff were friendly, breakfast was good, parking was good, overall we're satisfied!"
Canada
Edna
The price is Rp1.696.387
Rp1.992.730 total
includes taxes & fees
1 Jan - 2 Jan 2026
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Interior detail
Airport Inn

Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
8.8 out of 10, Excellent, (972)
"Very clean room, friendly staff and secure parking."
United States
Christopher
The price is Rp1.660.329
Rp1.947.113 total
includes taxes & fees
1 Jan - 2 Jan 2026
Airport Inn
Fridge, microwave, coffee/tea maker, dining tables
Miller Apartments

Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.4 out of 10, Good, (15)
"Own bedroom was quiet and tidy, shared bathroom clean and tidy, good communication "
Australia
Kasey
The price is Rp1.257.825
Rp2.736.189 total
includes taxes & fees
5 Jan - 6 Jan 2026
Miller Apartments
Lobby
Inn By The SFO

Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.8 out of 10, Good, (1000)
"Excellent property!!! I would definitely recommend!!! Great stay!!! "
United States
David
Inn By The SFO
Lobby sitting area
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (7219)
"Great place to stay!"
United States
Isaiah
The price is Rp1.671.617
Rp2.658.374 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Riu Plaza Fisherman's Wharf
Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (3841)
"Excellent stay and great location! "
United States
CHRISTINE
The price is Rp2.039.940
Rp3.170.697 total
includes taxes & fees
30 Jan - 31 Jan 2026
Hotel Caza Fisherman's Wharf
Exterior
The Westin San Francisco Airport

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2020)
"Comfortable room, welcome glass of wine, easy shuttle to and from airport, friendly staff."
United States
Carole
The price is Rp1.726.071
Rp2.474.952 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Westin San Francisco Airport
Front of property – evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2211)
"We loved our stay! "
United States
Christine
The price is Rp1.498.992
Rp1.764.239 total
includes taxes & fees
8 Jan - 9 Jan 2026
Hilton San Francisco Financial District
American cuisine
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront
4.0 star property
9.9 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2795)
"Breakfast was very good, many options to choose. "
United States
Hourn
The price is Rp1.758.942
Rp1.999.828 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton San Francisco Airport Bayfront
Exterior
Aloft San Francisco Airport

Aloft San Francisco Airport

Aloft San Francisco Airport
3.0 star property
6.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2231)
"Spotless — not fancy but clean open and comfortable !!! Great airport hotel!!!!"
United States
Michael
The price is Rp1.889.085
Rp2.171.410 total
includes taxes & fees
1 Jan - 2 Jan 2026
Aloft San Francisco Airport
Breakfast, lunch, dinner served; local cuisine
DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport
4.0 star property
9.3 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1398)
"Great location and staff"
United States
Ernest Dean
The price is Rp1.916.422
Rp2.178.876 total
includes taxes & fees
17 Jan - 18 Jan 2026
DoubleTree by Hilton San Francisco Airport
Lobby
Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport
2.5 star property
11.8 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1256)
"Good place to stay, clean and good breakfast."
United States
Xiaohong
The price is Rp1.584.692
Rp1.821.525 total
includes taxes & fees
3 Jan - 4 Jan 2026
Best Western Inn & Suites San Mateo - San Francisco Airport
Interior entrance
Hotel Aura SFO

Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2554)
"Clean, quiet, close to the airport."
United States
RICHARD
The price is Rp1.584.859
Rp1.902.481 total
includes taxes & fees
25 Jan - 26 Jan 2026
Hotel Aura SFO
Games room
Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
16.8 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2346)
"Great location"
United States
Deborah
The price is Rp2.099.058
Rp3.062.672 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Zephyr San Francisco
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
14.7 km from Downtown South San Francisco
9.4 out of 10, Exceptional, (3118)
"Clean room, helpful staff and great location to explore de city."
United States
Alan
The price is Rp1.270.235
Rp1.500.911 total
includes taxes & fees
4 Jan - 5 Jan 2026
Chancellor Hotel on Union Square
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2844)
"Clean room, friendly staff and good location"
United States
Jose Eduardo
The price is Rp1.681.796
Rp1.979.390 total
includes taxes & fees
4 Jan - 5 Jan 2026
Club Quarters Hotel in San Francisco
Outdoor pool, open 9:00 AM to 7:00 PM, pool loungers
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
14.8 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (5063)
"Nice stay. Hotel was clean, quiet and accessible. "
United States
Brandon
The price is Rp1.995.749
Rp2.348.946 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Golden Gateway by IHG
Front of property – evening/night
Hotel Nikko San Francisco

Hotel Nikko San Francisco

Hotel Nikko San Francisco
4.5 star property
14.3 km from Downtown South San Francisco
9.4 out of 10, Exceptional, (2660)
"Great service, great location, great hotel. "
United States
Laura
The price is Rp2.551.708
Rp3.774.314 total
includes taxes & fees
23 Jan - 24 Jan 2026
Hotel Nikko San Francisco
Exterior
Half Moon Bay Lodge

Half Moon Bay Lodge

Half Moon Bay Lodge
3.0 star property
24.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1092)
"Always great staff here, nice rooms, nice jacuzzi "
United States
Pamela
The price is Rp2.422.571
Rp2.842.392 total
includes taxes & fees
5 Jan - 6 Jan 2026
Half Moon Bay Lodge
Free daily buffet breakfast
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
16.6 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (2251)
"Awesome place to stay"
United States
Mark Anthony
The price is Rp1.995.749
Rp2.893.954 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express and Suites Fisherman's Wharf by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
Union Square featuring a skyscraper and a city

Union Square

Fashion puts on its finest face in one of the country’s largest shopping plazas.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

Fisherman\'s Wharf featuring a bay or harbour

Fisherman's Wharf

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

South of Market which includes skyline, a park and cbd

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill showing street scenes and a city

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Downtown South San Francisco Hotel Reviews

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

10/10 Excellent
"The room was clean and the staff was very accommodating and friendly. "
Lisa 1-night trip
Posted 21 hours ago
Hilton San Francisco Airport Bayfront

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.
What's a favourite place to stay in Downtown South San Francisco?
Based on Expedia customer reviews, La Quinta Inn & Suites by Wyndham San Francisco Airport N is a highly ranked property in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool. Other favourite options in the area include Airport Inn and Inn By The SFO.
How many hotels should I expect to find in the Downtown South San Francisco area?
When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 14 Expedia hotels and other accommodation options in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.
What can I see and do in this South San Francisco neighbourhood?
See's Candies, Cinemark Century at Tanforan and K1 Speed are just a few of the places to visit in and around Downtown South San Francisco. K1 Speed San Francisco and The Shops at Tanforan are also worth a visit when you're out sightseeing in South San Francisco.