The Best Hotels in Downtown South San Francisco, San Francisco - 2026 Updated Prices

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Compare popular hotels in Downtown South San Francisco

Property	Property class	Guest rating
Airport Inn	2.0 star property	9.0 Wonderful 1,005 reviews	View
La Quinta Inn & Suites by Wyndham San Francisco Airport N	3.0 star property	8.2 Very good 2,145 reviews	View
Miller Apartments	2.0 star property	7.2 Good 26 reviews	View
Inn By The SFO	2.0 star property	7.6 Good 1,001 reviews	View
Galleria Park Hotel	4.0 star property	9.6 Exceptional 1,060 reviews	View

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Fashion puts on its finest face in one of the country’s largest shopping plazas.

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Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

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A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

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A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

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A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

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Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"It was the perfect stay for my son's birthday trip. It was the perfect location, rooms were clean, staff was helpful and friendly. I highly recommend this hotel and will stay again on future trips to San Francisco."

Bay Landing San Francisco Airport Hotel

8/10 Good

"The staff, room, and view were all excellent! One star deduction because of a shuttle no-show, and calls to the hotel were all routed though a stupid AI ‘helper’ that didn’t know when the last pickup at the airport should be and we missed it, then waited a half hour for it to show up. Last pickup is at 10:30, even though the shuttle “runs” until 11 pm. Frustrating!"

Holiday Inn Golden Gateway by IHG

8/10 Good

"Thank you , Holiday Inn San Francisco!! The view from my room was BREATH TAKING ! The Hotel was clean ! Staff were all polite and extremely helpful ! And I loved all of the amenities like the pool and the gym ! I truly enjoyed all of the surrounding restaurants and nightlife just outside of the hotel ! Definitely going to book again !"

Hilton San Francisco Union Square

8/10 Good

"A Comfortable and Spacious Room, but Some Maintenance Issues ⭐⭐⭐⭐ We stayed at Hilton San Francisco Union Square for the final night of our San Francisco vacation. Despite the hotel’s impressive size and the long check-in line, the process was surprisingly efficient and well organized. Our room was spacious, clean overall, and well equipped. The heating worked perfectly, and the in-room coffee-making facilities were a welcome convenience. We particularly appreciated the exceptionally comfortable lounge chair, which provided a wonderful place to relax after a long day exploring San Francisco. However, there were some disappointing details that deserve attention. The mattress was excessively soft and appeared worn out. More concerningly, both the bedsheets and duvet covers showed considerable signs of wear, including visible holes and deteriorating fabric. These are basic comfort and quality issues that should not be overlooked at a hotel of Hilton’s reputation. Another noticeable drawback was the condition of the windows. They were extremely dirty, which significantly detracted from the enjoyment of the room and its view. Despite these shortcomings, we appreciated the spacious accommodation, comfortable lounge chair, effective heating, and convenient amenities. Overall, we had a pleasant stay, but better maintenance, replacement of worn bedding, and more thorough window cleaning would make a significant difference. Four stars for a generally comfortable experience"

Frequently asked questions

What's it like in Downtown South San Francisco?

You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.

What's a favourite place to stay in Downtown South San Francisco?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.

How many hotels should I expect to find in the Downtown South San Francisco area?

When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 11 Expedia hotels and other accommodation options in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.

What can I see and do in this South San Francisco neighbourhood?

South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.

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Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

3. Miller Apartments

4. Inn By The SFO

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

6. Comfort Inn and Suites San Francisco Airport North

7. Hotel Nova SFO

8. Best Western Plus Grosvenor Airport Hotel

9. Home2 Suites by Hilton San Francisco Airport North

10. Hilton Garden Inn San Francisco Arpt North

11. Sonesta Select San Francisco Airport Oyster Point Waterfront

12. The Atrium Hotel

13. Hotel Skye SFO

14. Hotel Aura SFO

15. The Dylan at SFO

16. Hotel Nikko San Francisco

17. DoubleTree by Hilton San Francisco Airport North Bayfront

18. LUMA Hotel San Francisco

19. Hotel Riu Plaza Fisherman's Wharf

20. The Millwood - A Boutique Hotel

Compare popular hotels in Downtown South San Francisco

Where to stay in Downtown South San Francisco

Union Square

Downtown San Francisco

Fisherman's Wharf

South of Market

Nob Hill

Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Frequently asked questions

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