Eastern Panama Holidays

Book a Hotel + Flight or Car together to unlock savings

Photo by Nico Barner

  • Plan, book, travel with confidence

  • Better together

    Save up to Rp16.000.000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Eastern Panama

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on 15 Mar 2026

Get rates
Private Ocean-Front Cabin with private bathroom on San Blas Island
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
The price is Rp2.247.714 per night from 16 Jun to 17 Jun
Rp2.247.714
Rp2.472.485 total
16 Jun - 17 Jun
includes taxes & fees
9.8/10 Exceptional! (18 reviews)
"Here's a natural, conversational review in English: We had a wonderful stay here. The hotel is beautiful, with an amazing pool overlooking both the ocean and the rainforest. Everything was very clean, and the beds were extremely comfortable. The staff were incredibly friendly and welcoming. The owner ..."

Reviewed on 2 Jun 2026

Ranchos de Chalia
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale Cacique Provincia de Colón
Fully refundableReserve now, pay when you stay
The price is Rp3.692.673 per night from 23 Jun to 24 Jun
Rp3.692.673
Rp4.061.940 total
23 Jun - 24 Jun
includes taxes & fees
10/10 Exceptional! (10 reviews)
"The views from this mountain-top boutique hotel are extraordinary."

Reviewed on 1 Feb 2026

Ciel y Miel
See all 186 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Can I cancel my flight booking to Eastern Panama due to COVID-19?
Our Customer Service Portal is where you can find useful information about cancelling or changing your flight due to COVID-19. Before booking your tickets, it's wise to scroll through the terms and conditions of your airfare too.
What's the best way to find cheap flights to Eastern Panama that have flexible change policies?
It's as easy as counting to three with Expedia. Firstly, enter your travel details and press "Search." Second step: Check the "No change fee" box under the "Flexible change policies" heading to the left of your screen. Step 3. Nab a cheap and flexible flight to Eastern Panama.
What are some of the general tips for travellers to Eastern Panama during the COVID-19 outbreak?
COVID-19 has resulted in significant changes to the way we travel. If you plan to jet off to Eastern Panama, these tips will help you navigate the "new normal:"
  • Before you lock in a flight, find out if any travel restrictions apply — in both your destination and origin. Keep informed with the latest updates by checking government and travel websites.
  • When you go through airport screening, keep your face mask on. You will be asked to lower it briefly to verify your identity. Passengers who refuse to wear a face mask may face civil penalties and may also be escorted from the building.
  • Rather than handing a TSA agent your boarding pass, position it directly on the reader yourself. Once that's done, hold it up for inspection.
  • TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag and presented for screening.
  • To minimize handling during screening, place items such as your phone, keys and wallet into your carry-on instead of the bins.
  • Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on means it's less likely a TSA employee will need to open and touch your bag for inspection.

Which airlines fly to Eastern Panama?
Copa Airlines is a well-known airline servicing Eastern Panama. Search for airfares to Tocumen Intl. Airport (PTY) and you'll have 3173 Copa Airlines flights every month to choose from.
How can I find cheap tickets to Eastern Panama?
You'll always find a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred travel date, then click on the flexible dates box above to see prices for nearby days. was the cheapest price for a flight to Eastern Panama in the last seven days.
How much is a flight to Eastern Panama?
There were lots of low-cost fares for the taking in the last seven days, with the cost of a round-trip flight to Eastern Panama varying between and . Many lucky travellers locked in one-way flights from () for only .
What are the most popular airports to fly into in Eastern Panama?
The main gateway to Eastern Panama, roughly 3507 flights land at Tocumen Intl. Airport (PTY) each month. Track down a top deal, book your seat and get ready to enjoy the best of this amazing region.
When is the cheapest time to fly to Eastern Panama?
Jetting off on a Tuesday, followed by a Monday, is generally the best way to land the cheapest fare. Steer clear of the weekend if you can, because Saturday is typically the most expensive day. Spend the dollars you saved having a good time in Eastern Panama instead!
How much is a plane ticket to Eastern Panama?
Prices varied from to over the last seven days. When you're ready to book, we'll be ready to help you pick up the best deal to Eastern Panama.
What months are the cheapest to book a flight to Eastern Panama?
February is the cheapest month to purchase a seat for your Eastern Panama break. Fares cost the most during the busy month of December, so avoid this time if you can.
Which airlines with flights to Eastern Panama employ COVID-19 cleanliness policies?
In order to minimize contact between passengers and cabin crew during the COVID-19 outbreak, the majority of airlines have taken social distancing and other measures to the skies. Just a few of these are:
  • Copa Airlines - this airline is known for conducting passenger temperature checks and electrostatic cleaning.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

How long is a flight to Eastern Panama?
This depends on several factors, particularly the city you're taking off from. Here are some of the most popular services to Eastern Panama and average travel times:
  • Boston, MA Airport (BOS-Logan Intl.) to Tocumen Intl. Airport (PTY) - 5 hours and 21 minutes
  • Tampa, FL Airport (TPA-Tampa Intl.) to Tocumen Intl. Airport (PTY) - 2 hours and 58 minutes
  • Newark, NJ Airport (EWR-Liberty Intl.) to Tocumen Intl. Airport (PTY) - 5 hours and 24 minutes

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.