Search Hotels in Isle of Palms, Jacksonville

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11 Dec - 12 Dec
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Our top choices for Isle of Palms hotels

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (446)
"Great facility to stay."
United States
Gary
The price is Rp2.484.724
Rp2.820.162 total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Restaurant
Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport
2.5 star property
30.8 km from Isle of Palms
9.0 out of 10, Wonderful, (98)
"Will stay here again "
United States
Jose
The price is Rp1.200.505
Rp1.362.596 total
includes taxes & fees
15 Dec - 16 Dec
Extended Stay America Premier Suites - Jacksonville - Airport
Outdoor pool
Hilton Garden Inn Jacksonville Airport

Hilton Garden Inn Jacksonville Airport

Hilton Garden Inn Jacksonville Airport
3.0 star property
31.5 km from Isle of Palms
8.6 out of 10, Excellent, (892)
"Everything was hood "
United States
Rosendo
The price is Rp1.254.938
Rp1.424.354 total
includes taxes & fees
19 Dec - 20 Dec
Hilton Garden Inn Jacksonville Airport
Lobby
Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport
3.0 star property
31.1 km from Isle of Palms
9.0 out of 10, Wonderful, (2267)
"Room eas clean staff was great"
United States
Joshua
The price is Rp1.615.904
Rp1.834.051 total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Place Jacksonville Airport
Outdoor pool
Hampton Inn Jacksonville East Regency Square

Hampton Inn Jacksonville East Regency Square

Hampton Inn Jacksonville East Regency Square
2.5 star property
13 km from Isle of Palms
8.6 out of 10, Excellent, (1006)
"We stay here every time we visit family, very convenient, clea, friendly and quiet. "
United States
Robin
The price is Rp1.454.147
Rp1.650.457 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Jacksonville East Regency Square
Exterior
Holiday Inn Express Jacksonville - Blount Island by IHG

Holiday Inn Express Jacksonville - Blount Island by IHG

Holiday Inn Express Jacksonville - Blount Island by IHG
2.5 star property
20.3 km from Isle of Palms
8.6 out of 10, Excellent, (1000)
"Room was spotless, staff very friendly "
United States
Heidi
The price is Rp1.518.608
Rp1.723.620 total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Jacksonville - Blount Island by IHG
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
2.1 km from Isle of Palms
9.2 out of 10, Wonderful, (53)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is Rp2.037.474
Rp2.312.534 total
includes taxes & fees
21 Dec - 22 Dec
Hilton Jacksonville At Mayo Clinic
Daily buffet breakfast (USD 26.95 per person)
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville
4.0 star property
22.3 km from Isle of Palms
9.0 out of 10, Wonderful, (1381)
"Nice stay"
United States
April
The price is Rp2.401.344
Rp2.752.781 total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Regency Jacksonville
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (3426)
"Excellent location & property "
United States
Doris
The price is Rp2.386.336
Rp2.708.683 total
includes taxes & fees
15 Dec - 16 Dec
Margaritaville Jacksonville Beach
Exterior
Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.8 km from Isle of Palms
8.6 out of 10, Excellent, (1001)
"very safe and easy to get to "
United States
Melissa
The price is Rp1.401.792
Rp1.591.033 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Jacksonville E 295 Baymeadows by IHG
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1001)
"Great stay and great customer service"
United States
Rebecca
The price is Rp1.488.333
Rp1.689.257 total
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel
Outdoor pool, open 8:00 AM to 8:00 PM, pool umbrellas, pool loungers
Seahorse Oceanfront Inn

Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.7 km from Isle of Palms
9.0 out of 10, Wonderful, (601)
"Location,location, location. "
United States
Blake
Seahorse Oceanfront Inn
Lobby
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms
9.0 out of 10, Wonderful, (1014)
"We have stayed here in the past,excellent location. We especially enjoyed our food from Mulligan's..our waitress was exceptional. "
United States
Robert
The price is Rp1.914.614
Rp2.134.794 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Lobby
Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk
3.5 star property
22 km from Isle of Palms
8.2 out of 10, Very good, (1606)
"Great service, location, staff and food!"
United States
Thomas
The price is Rp1.637.093
Rp1.858.100 total
includes taxes & fees
2 Jan - 3 Jan 2026
Southbank Hotel by Marriott Jacksonville Riverwalk
Free daily buffet breakfast
Hampton Inn & Suites Jacksonville South - Bartram Park

Hampton Inn & Suites Jacksonville South - Bartram Park

Hampton Inn & Suites Jacksonville South - Bartram Park
3.0 star property
18.5 km from Isle of Palms
9.0 out of 10, Wonderful, (1001)
"Room is spacious clean and nicely decorated.i haventvhad breakfast yet but ill bet it will be good.staff very friendly"
United States
Jeff
The price is Rp1.454.147
Rp1.650.457 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Jacksonville South - Bartram Park
Exterior
Holiday Inn Express & Suites Jacksonville Airport by IHG

Holiday Inn Express & Suites Jacksonville Airport by IHG

Holiday Inn Express & Suites Jacksonville Airport by IHG
2.5 star property
31.3 km from Isle of Palms
8.6 out of 10, Excellent, (1011)
"Front desk check in was excellent!"
United States
Janet
The price is Rp1.468.544
Rp1.666.798 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express & Suites Jacksonville Airport by IHG
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1000)
"Good location, friendly staff, clean "
United States
john
The price is Rp1.989.210
Rp2.257.755 total
includes taxes & fees
13 Dec - 14 Dec
Hyatt Place Jacksonville / St. Johns Town Center
Outdoor pool, open 7:00 AM to 7:00 PM, pool umbrellas, pool loungers
One Ocean Resort and Spa

One Ocean Resort and Spa

One Ocean Resort and Spa
4.5 star property
6.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1001)
"Clean rooms and very nice staff "
United States
Arthur
The price is Rp2.320.465
Rp3.171.608 total
includes taxes & fees
21 Dec - 22 Dec
One Ocean Resort and Spa
Property amenity
Courtyard by Marriott Jacksonville Flagler Center

Courtyard by Marriott Jacksonville Flagler Center

Courtyard by Marriott Jacksonville Flagler Center
3.0 star property
17.8 km from Isle of Palms
8.8 out of 10, Excellent, (1000)
"Stay here everytime I need to be in downtown Jacksonville"
United States
Catherine
The price is Rp1.600.896
Rp1.817.017 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Jacksonville Flagler Center
Exterior
Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
2.5 star property
5 km from Isle of Palms
8.6 out of 10, Excellent, (888)
"Great place to stay highly recommend it"
United States
Taryn
The price is Rp1.901.064
Rp2.157.708 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott Jacksonville Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms

Find the best Isle of Palms areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Southside

If you're spending some time in Southside, St. Johns Town Center and Merill Road Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Cummer Museum of Art and Gardens featuring art and interior views as well as a couple
Photo by Visit Jacksonville
Open Photo by Visit Jacksonville

Northwest

While visiting Northwest, you might make a stop by sights like Cummer Museum of Art and Gardens and Jacksonville-Baldwin Rail Trail.

Top Isle of Palms Hotel Reviews

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"Clean. Very friendly staff."
Mark 1-night trip
Posted 10 days ago
Hilton Jacksonville At Mayo Clinic

Explore a world of travel with Expedia

Frequently asked questions

What is Isle of Palms like?
Travellers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighbourhood.
What's a favourite hotel to stay in Isle of Palms?
Based on Expedia customer reviews, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is the highest ranked property in Isle of Palms. This hotel offers free breakfast and an outdoor pool.
How many hotels should I expect to find in Isle of Palms?
Expedia has 37 hotels and other accommodation options in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to view the best deals available in Isle of Palms.
What is there to do in this Jacksonville Beach neighbourhood?
A few places to visit in the area around Isle of Palms include Adventure Landing, Cradle Creek Preserve and Jacksonville Beach Golf Club. While you're out sightseeing in Jacksonville Beach, make sure that you visit other sights such as Windsor Parke Golf Club or Players by the Sea.