Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

1. Depot Inn and Suites

La Plata

Kimberly

Rp1.788.968 total

includes taxes & fees

6 Dec - 7 Dec

A buffet with various food items, including omelets and other dishes, arranged in metal serving trays.

2. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

Rp2.333.439 total

includes taxes & fees

29 Nov - 30 Nov

A bathroom with a large bathtub, a chair, and a small shelf with plants.

3. Pinemark Inn & Suites

St. Clair

Michael

Rp2.658.332 total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

4. Best Western On The River

Hannibal

Rob

Rp2.104.078 total

includes taxes & fees

12 Nov - 13 Nov

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

5. Comfort Inn Sullivan

Sullivan

Wayne

Rp2.241.902 total

includes taxes & fees

2 Dec - 3 Dec

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

6. Sleep Inn & Suites Hannibal West

Hannibal

Sarah

Rp2.304.308 total

includes taxes & fees

6 Dec - 7 Dec

A modern kitchen with a dining area, featuring a kitchen island with appliances and a coffee station.

7. Super 8 by Wyndham Kirksville-University Area

Kirksville

Cori

Rp1.318.729 total

includes taxes & fees

26 Nov - 27 Nov

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

8. Best Western Plus Washington Hotel

Washington

Carl

Rp2.755.539 total

includes taxes & fees

12 Nov - 13 Nov

A hotel lobby with a seating area, a dining table, a kitchen, and an exit sign.

9. Super 8 by Wyndham Washington

Washington

Gary

Rp1.647.143 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

10. Oak Hill Inn & Suites

Canton

Peter

Rp1.934.092 total

includes taxes & fees

1 Dec - 2 Dec

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

11. Travelier Motel

Macon

Jason

Rp978.788 total

includes taxes & fees

12 Nov - 13 Nov

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

12. Hampton Inn By Hilton Warrenton I-70

Warrenton

Richard

Rp3.020.013 total

includes taxes & fees

13 Nov - 14 Nov

A modern hotel lobby with a high ceiling, a central seating area with sofas and a coffee table, and a flat-screen TV mounted on the wall.

13. Drury Inn & Suites Southwest St. Louis

Valley Park

Crystal

Rp2.514.302 total

includes taxes & fees

18 Nov - 19 Nov

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

14. The Wildwood Hotel

Wildwood

Lori

Rp1.683.150 total

includes taxes & fees

8 Dec - 9 Dec

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

15. Holiday Inn Express & Suites St Peters by IHG

St. Peters

Roxanne

Rp2.561.733 total

includes taxes & fees

22 Nov - 23 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

16. Hyatt Place St. Louis/Chesterfield

Chesterfield

Karin

Rp2.715.088 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a bed, a lamp, a mirror, and a door.

17. Town & Country Inn and Suites

Quincy

Kelly

Rp2.575.366 total

includes taxes & fees

1 Dec - 2 Dec

A spacious lobby with a central round table, two sofas, and a chandelier.

18. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

messia

Rp2.723.257 total

includes taxes & fees

17 Nov - 18 Nov

A spacious lobby with a checkered floor, a large framed welcome sign, a ceiling fan, and a bar area.

19. Super 8 by Wyndham Union

Union

William

Rp1.580.355 total

includes taxes & fees

23 Nov - 24 Nov

A modern interior with hanging pendant lights, large windows, and a view of the outside.

20. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Fenton

michael

Rp1.861.705 total

includes taxes & fees

15 Nov - 16 Nov

View all properties

Holiday Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

Spacious 3-Bedroom with King Bed

Central West End

"Had a great stay! I hosted a birthday dinner for my best friend! Everything was clean and looked great"

Treehouse

A wooden bridge leading to a two-story house with multiple windows and a covered porch.

The Cottage

Hermann

"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Apartment

A wooden dock extending into a calm lake surrounded by lush greenery.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Cottage

Peaceful Missouri Cabin Rental on Large Property

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A sauna room with wooden benches and frosted glass windows.

Augusta Studio at Halcyon Spa Bed & Breakfast

Augusta

"Everything was great with this place"

Apartment

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

Studio Stay w/ Deck in Missouri Wine Country

New Haven

"It is a clean efficiency with modern amenities but with a touch of country flair! Sara is the property manager and is absolutely wonderful! Based on their availability, I would absolutely stay there again!!!!! Even if I can't stay there, I am definitely going to get some of thar great ice cream and home cooking at the restaurant in the same building!"

Apartment

A red building with a sign for 'Catala House' and a 'Massage House' sign.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Cottage

A spacious room with a wooden interior, a staircase, a sofa, a table, and a cabinet.

Hillside Cabin on 43 Acres w/ Private Lake & View!

Defiance

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

See properties

Learn more about Northeast Missouri

Great live music, sports teams and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theatres.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

Pear Tree Inn St. Louis Airport

10/10 Excellent

"Nachos and drinks at happy hour. Full hot breakfast. Lovely room"

Clayton Plaza Hotel & Extended Stay

8/10 Good

"The room was very clean; the cleaning staff was somewhat hesitant to provide me with extra towels and wash cloths upon request. The breakfast bar was very nice; however, on the weekend the omlet bar was not opened until 7:00am (omlets were cooked to specification). You could not carry food out to your room or fix a plate to take with you on the road. This was very inconveient for me as I needed to leave hotel by 6:30am to drive to St. Louis Convention Center 20 miles away, park in 9th St garage and walk to 11th St to the Convention Center for morning services at 7am. It would have been nice to have been able to take a cup of fruit with me. The hotel had lots of garage parking; however, there were no lights in the garage except a flood light by the door entrance that led into the hotel. Parking at night was uncanningly frightening because once you parked your car, if you were not close to the flood light that lit up the door entrance or didn't have a flash light, it was pitch black. Thankfully, I had a very powewrful flashlight I keep in my car which came in handy. The hotel does not provide any other dining other than breakfast."

Ameristar Casino Resort and Spa

8/10 Good

"We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of hotel."

More cheap stays in Northeast Missouri

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO

Rp1.074.689

Rp1.246.510 total

22 Nov - 23 Nov

includes taxes & fees

4.4/10 (1,006 reviews)

Explore a world of travel with Expedia

More ways to book

Book Hotels in Northeast Missouri on Expedia.com

Find hotels in Northeast Missouri, MO from Rp1.246.510

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Northeast Missouri

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Northeast Missouri hotels

1. Depot Inn and Suites

2. Holiday Inn Express & Suites Kirksville - University Area by IHG

3. Pinemark Inn & Suites

4. Best Western On The River

5. Comfort Inn Sullivan

6. Sleep Inn & Suites Hannibal West

7. Super 8 by Wyndham Kirksville-University Area

8. Best Western Plus Washington Hotel

9. Super 8 by Wyndham Washington

10. Oak Hill Inn & Suites

11. Travelier Motel

12. Hampton Inn By Hilton Warrenton I-70

13. Drury Inn & Suites Southwest St. Louis

14. The Wildwood Hotel

15. Holiday Inn Express & Suites St Peters by IHG

16. Hyatt Place St. Louis/Chesterfield

17. Town & Country Inn and Suites

18. Drury Plaza Hotel St. Louis Chesterfield

19. Super 8 by Wyndham Union

20. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Holiday Rentals in Northeast Missouri

Cannon Dam Cabins

Stay near popular Northeast Missouri attractions

St. Louis Zoo

Learn more about Northeast Missouri

Top Northeast Missouri Hotel Reviews

Pear Tree Inn St. Louis Airport

More cheap stays in Northeast Missouri

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Explore a world of travel with Expedia

Go further with the Expedia app