Search Hotels in Prague 21, Prague

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Prague 21 hotels

Holiday Inn Prague Airport by IHG

Holiday Inn Prague Airport by IHG
4.0 star property
28.4 km from Prague 21
8.8 out of 10, Excellent, (1003)
"The room was clean and breakfast was good "
United States
Kest
The price is Rp1.498.081
Rp1.759.062 total
includes taxes & fees
26 Jan - 27 Jan 2026
Holiday Inn Prague Airport by IHG

Dvůr Hoffmeister

Dvůr Hoffmeister
3.0 star property
31.9 km from Prague 21
9.6 out of 10, Exceptional, (92)
"The lovely bathroom and jet tub Place was pretty nice and away from the busy tourist areas "
United States
Natisha
Dvůr Hoffmeister

Majestic Plaza Hotel Prague

Majestic Plaza Hotel Prague
4.5 star property
Nové Město, 17.7 km from Prague 21
9.0 out of 10, Wonderful, (1091)
"Clean room, friendly staff, lovely balcony."
United Kingdom
Jude
The price is Rp1.143.976
Rp1.362.465 total
includes taxes & fees
20 Jan - 21 Jan 2026
Majestic Plaza Hotel Prague

Aurea Legends by Eurostars Hotel Company

Aurea Legends by Eurostars Hotel Company
4.0 star property
Nové Město, 18 km from Prague 21
9.8 out of 10, Exceptional, (187)
"Great Hotel"
Canada
Yitao
The price is Rp1.092.929
Rp1.304.109 total
includes taxes & fees
27 Jan - 28 Jan 2026
Aurea Legends by Eurostars Hotel Company

SKY Hotel Prague

SKY Hotel Prague
3.5 star property
26.1 km from Prague 21
8.6 out of 10, Excellent, (583)
"Very clean, comfortable. Well-lit with good locations of lights. The bed was comfortable and linens were great. There is a nice coffee machine in the lobby that makes espresso. Nice gentleman helped us with accessing our room. I really recommend this hotel and we enjoyed the visit, staying two extra nights."
United States
Lisa
SKY Hotel Prague

Michelangelo Grand Hotel Prague

Michelangelo Grand Hotel Prague
5.0 star property
Nové Město, 18 km from Prague 21
9.4 out of 10, Exceptional, (3166)
"Great room, comfy bed, great breakfast, location excellent "
United Kingdom
Carol
Michelangelo Grand Hotel Prague

Courtyard by Marriott Prague Airport

Courtyard by Marriott Prague Airport
4.0 star property
29 km from Prague 21
9.2 out of 10, Wonderful, (1002)
"Fantastic stay experience "
Canada
Yitao
The price is Rp2.521.213
Rp2.905.023 total
includes taxes & fees
18 Jan - 19 Jan 2026
Courtyard by Marriott Prague Airport

Charles Bridge Palace

Charles Bridge Palace
4.0 star property
Stare Mesto, 18.4 km from Prague 21
9.2 out of 10, Wonderful, (1003)
"We enjoyed our stay! The staff were wonderful and the location was amazing."
Australia
Robert
Charles Bridge Palace

Grandium Hotel Prague

Grandium Hotel Prague
5.0 star property
Nové Město, 17.3 km from Prague 21
9.2 out of 10, Wonderful, (1107)
"Great rooms, friendly staff, wonderful breakfast"
United States
Toni
The price is Rp1.495.913
Rp1.756.697 total
includes taxes & fees
25 Jan - 26 Jan 2026
Grandium Hotel Prague

a&o Prague Rhea

a&o Prague Rhea
3.0 star property
12.4 km from Prague 21
8.0 out of 10, Very good, (612)
"Everything was excellent "
United Kingdom
Babington
The price is Rp529.027
Rp673.774 total
includes taxes & fees
7 Jan - 8 Jan 2026
a&o Prague Rhea

Iron Gate Hotel & Suites Prague by BHG

Iron Gate Hotel & Suites Prague by BHG
5.0 star property
Stare Mesto, 18.1 km from Prague 21
9.2 out of 10, Wonderful, (1003)
"Beautiful rustic hotel in an excellent location"
United States
Paula
The price is Rp1.488.024
Rp1.748.193 total
includes taxes & fees
18 Jan - 19 Jan 2026
Iron Gate Hotel & Suites Prague by BHG

Mosaic House Design Hotel

Mosaic House Design Hotel
4.0 star property
Nové Město, 18.2 km from Prague 21
9.8 out of 10, Exceptional, (722)
"Breakfast is very good, nice staffs"
Hong Kong SAR China
Wilson
Mosaic House Design Hotel

Hotel Exe City Park

Hotel Exe City Park
3.0 star property
Nové Město, 17.1 km from Prague 21
9.0 out of 10, Wonderful, (1005)
"Friendly staff, large room, big comfy bed, decent location. The only let down was the breakfast selection was small"
United Kingdom
Stephanie
The price is Rp871.182
Rp1.054.176 total
includes taxes & fees
28 Jan - 29 Jan 2026
Hotel Exe City Park

Hotel Adalbert

Hotel Adalbert
3.0 star property
22.6 km from Prague 21
9.2 out of 10, Wonderful, (533)
"Spacious, clean, easy parking, great breakfast and kind staff "
United States
JI YEOUL
Hotel Adalbert

Art Deco Imperial Hotel

Art Deco Imperial Hotel
5.0 star property
Petrská čtvrť, 17.2 km from Prague 21
9.6 out of 10, Exceptional, (1003)
"Amazing hotel ! We really enjoyed it! Great staff, perfect room service , clean and delicious food! Highly recommended "
United States
Svetlana
The price is Rp2.059.158
Rp2.387.469 total
includes taxes & fees
20 Jan - 21 Jan 2026
Art Deco Imperial Hotel

Hilton Prague

Hilton Prague
5.0 star property
16.7 km from Prague 21
8.4 out of 10, Very good, (1007)
"Very excellent Hotel would recommend to anyone!"
Canada
Damien
The price is Rp1.307.439
Rp1.544.759 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hilton Prague

Allure Hotel & Residence Prague

Allure Hotel & Residence Prague
4.0 star property
Stare Mesto, 18 km from Prague 21
10.0 out of 10, Exceptional, (589)
"The hotels is traditional but has recently been redecorated so the rooms and amenities are very modern. Staff was very communicative, friendly and helpful. Would highly recommend and stay again when in Prague. "
United Kingdom
Alice
The price is Rp2.094.357
Rp2.426.103 total
includes taxes & fees
6 Jan - 7 Jan 2026
Allure Hotel & Residence Prague

Hotel Golf Prague

Hotel Golf Prague
4.0 star property
23.6 km from Prague 21
8.8 out of 10, Excellent, (640)
"Staff were okay, the hotel is very clean, and breakfast was great!!! All fresh foods!! I wish parking was a bit cheaper though. I would definitely recommend "
United States
Philomena
The price is Rp1.161.576
Rp1.382.177 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Golf Prague

Grand Majestic Hotel Prague

Grand Majestic Hotel Prague
4.0 star property
Petrská čtvrť, 17.4 km from Prague 21
9.2 out of 10, Wonderful, (1184)
"Clean rooms, quiet, great location"
Canada
Debra
The price is Rp1.407.971
Rp1.658.139 total
includes taxes & fees
4 Jan - 5 Jan 2026
Grand Majestic Hotel Prague

Art Nouveau Palace Hotel

Art Nouveau Palace Hotel
5.0 star property
Nové Město, 17.5 km from Prague 21
9.4 out of 10, Exceptional, (1001)
"Excellent hotel with friendly staff, great decor and convenient. Highly recommend this hotel."
United Kingdom
John
The price is Rp1.668.446
Rp1.949.872 total
includes taxes & fees
11 Jan - 12 Jan 2026
Art Nouveau Palace Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Prague 21

Find the best Prague 21 areas for the activities you enjoy most.

Prague City Center

Charles Bridge Museum and Museum of Medieval Torture are top sights in Prague City Center, and you should be sure to explore the acclaimed art galleries. Hop aboard the metro at Karlovy Lázně Stop or Staroměstská Stop to see more sights in the area.

Stare Mesto

The geographical and historical heart of Prague, this UNESCO-listed district features a tangle of cobblestone streets lined by Baroque churches, palaces and houses.

Nové Město

Dynamic and buzzy, this central commercial district is packed with cultural attractions, chic shops and ample dining and drinking options.

Prague 1

Known for its popular shops and acclaimed art galleries, there's plenty to explore in Prague 1. Check out top attractions like Old Town Square and Royal Route, and jump on the metro at Staromestska Station or Staroměstská Stop to see more of the city.

Prague 2

Known for its ample dining options and fascinating museums, there's plenty to explore in Prague 2. You can visit top attractions like Peace Square and New Town Hall, and jump on the metro at Náměstí Míru Stop or Namesti Miru Station to see more of the city.

Top Prague 21 Hotel Reviews

Frequently asked questions

What's it like in Prague 21?
Travellers will be sure to enjoy their time in Prague's Prague 21 neighbourhood.
If I need to cancel my hotel reservation in Prague 21, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. Enter your dates, click on "Search", then filter by "fully refundable" to review the best deals available in Prague 21.
What can I see and do in this Prague neighbourhood?
Some places to visit in the Prague area include House of the Black Madonna, Na Prikope and Powder Tower so get out of the neighbourhood to explore more of the city. While you're out sightseeing, Municipal House Hall and Museum of Communism are a couple of sights to visit in the city.
How can I get around Prague 21 and the greater Prague area?
If you're considering venturing out of town, train travel is a great option. Prague-Klanovice Station is the closest train station, but Prague-Běchovice střed Station and Prague-Bechovice Station are also close by.