Santa Clara Holidays

Book a Hotel + Flight or Car together to unlock savings

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  • Better together

    Save up to Rp16.000.000 when you book a flight and hotel together*

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Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is Rp2.435.448 per night from 17 Aug to 18 Aug
Rp2.435.448
Rp2.678.993 total
17 Aug - 18 Aug
includes taxes & fees
9/10 Wonderful! (5,758 reviews)
"Great staff great hotel best breakfast"

Reviewed on 22 Jul 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is Rp1.973.199 per night from 15 Aug to 16 Aug
Rp1.973.199
Rp2.170.519 total
15 Aug - 16 Aug
includes taxes & fees
8.6/10 Excellent! (2,621 reviews)
"Personal atento y servicial. Deben mejorar las duchas, están mohosas. No me pude comunicar con la recepción ni con room service, tuve que bajar al restaurante. No había servicio de TV en el momento. Buen buffet de desayuno."

Reviewed on 22 Jul 2026

Crowne Plaza Panama Airport by IHG
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
The price is Rp3.558.526 per night from 2 Aug to 3 Aug
Rp3.558.526
Rp3.914.379 total
2 Aug - 3 Aug
includes taxes & fees
8.4/10 Very good! (1,614 reviews)
"La localización del hotel la amabilidad del personal"

Reviewed on 23 Jul 2026

Megapolis Hotel Panamá
See all 1,810 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Clara holiday package cost?
Custom make your Santa Clara holiday package from as little as . Pick from any combination of hotels, flights and rental cars to craft the escape of your dreams. Be sure to add on some tours and experiences!
How do I get a cheap travel package to Santa Clara?
One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all. Select the combination that best fits you and watch your savings grow. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Clara getaway.
Where should I stay in Santa Clara?
Most travellers who visit Santa Clara include Miraflores Locks and Metropolitan Cathedral of Panama on their must-see lists. Why not select a hotel close to one of these main attractions?
How far in advance should I book my Santa Clara holiday?
Savvy travellers always book early. Air carriers generally advertise flights up to a year prior to departure, and this is a fantastic opportunity to score some of the cheapest prices. Just been told you should take some holiday time next week? No need to worry. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at an affordable price.
What does an Expedia Santa Clara travel package include?
It comes down to what you're looking for. If you're travelling solo, you might decide to combine hotels and flights. Bringing the whole family to Santa Clara? A travel package including flights, hotels and rental cars might suit you better. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking a Santa Clara travel package?
When you book your flights, hotels and car rentals together, you'll pick up awesome discounts. Whether you're organising a beach break in a villa or prefer to stay in an upscale city hotel, Expedia can make it happen for less.
Can I choose my airline with a Santa Clara Expedia holiday package?
Yes, you can. We offer more than 550 airline partners throughout the world, so opt for the carrier that fits your budget and travel needs.
If I'm not able to travel, can I cancel my Santa Clara holiday package?
Because we understand life is full of surprises, the answer is yes. For further details, check out our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for no charge. Your hotel, airline or car rental company may impose a fee if you made your booking a while ago.

Things to do

Panama Canal Half Transit Experience

Panama Canal Partial Transit

Rp2.678.850
per adult
84% of travellers recommend
Panama Canal Partial Transit
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

Rp573.306
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

Rp1.190.660
per adult
98% of travellers recommend
Half day of Panama city and canal tour: shared and private
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.