Santa Cruz Travel Guide

Tourist Guide

A colonial-style building with a bell tower, palm trees, and a paved walkway.
A brick building with arched windows and a spiral design on the facade.
A historic building with columns and flags, palm trees, and a clear blue sky.
A historic brick tower with a dome and bell, surrounded by lush green palm trees.
A historic church with two bell towers and a central facade.

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is Rp2.345.335 per night from 18 Aug to 19 Aug
Rp2.345.335
Rp2.345.335 total
18 Aug - 19 Aug
Stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...
9/10 Wonderful! (392 reviews)
"Wildlife on property. Great breakfast. Amazing spa. Great rooms. Professional atmosphere. My favorite hotel in Santa Cruz."

Reviewed on 21 Jul 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is Rp956.292 per night from 11 Aug to 12 Aug
Rp956.292
Rp956.292 total
11 Aug - 12 Aug
Stay at this business-friendly hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. ...
9.4/10 Exceptional! (127 reviews)
"Hotel muy lindo bien ubicado limpio el desayuno bueno y el personal A1 …. Totalmente recomendado"

Reviewed on 22 Jul 2026

Ibis Santa Cruz DE LA Sierra
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
The price is Rp2.901.092 per night from 3 Aug to 4 Aug
Rp2.901.092
Rp2.901.092 total
3 Aug - 4 Aug
Stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural Oriental ...
9/10 Wonderful! (433 reviews)
"Wonderful place to stay while visiting Santa Cruz Bolivia."

Reviewed on 7 Jul 2026

Camino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Stay at this business-friendly aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
Premium Suites Deluxe Aparthotel Equipetrol
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Stay at this business-friendly apartment in Santa Cruz. Enjoy free Wi-Fi, free parking and room service. Popular attractions Patio Design LifeStyle Center and ...
8.8/10 Excellent! (103 reviews)
"Great location."

Reviewed on 4 Jun 2026

Apart Hotel Premium Suites Santa Cruz
Terranova Suites

Terranova Suites

3.5 out of 5
7º Anillo 400 mts al Oeste de Santa Cruz Santa Cruz
Stay at this aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Popular attractions Las Brisas Shopping Center and Centro Cultural ...
8/10 Very good! (91 reviews)
"Hotel is clean and the breakfast was excellent. The rooms are older but good. I would stay again. Thanks!"

Reviewed on 4 Jul 2026

Terranova Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

Things to do