Santa Cruz Travel Guide

Tourist Guide

San Lorenzo Cathedral showing a garden
Santa Cruz featuring a city
San Lorenzo Cathedral featuring heritage architecture and heritage elements
Santa Cruz showing a city
San Lorenzo Cathedral

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

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Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Hamacas
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is Rp634.410 per night from 24 Dec to 25 Dec
Rp634.410
Rp634.410 total
24 Dec - 25 Dec
Stay at this business-friendly hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. ...
9.4/10 Exceptional! (72 reviews)
everything was perfect 👌

Reviewed on 27 Nov 2025

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is Rp1.848.700 per night from 12 Dec to 13 Dec
Rp1.848.700
Rp1.848.700 total
12 Dec - 13 Dec
Stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa and a rooftop terrace. Our guests praise the helpful staff in their reviews. ...
8.8/10 Excellent! (209 reviews)
The greeting employees at the entrancing the building and the restaurant employees, very friendly. Thank you

Reviewed on 10 Nov 2025

Marriott Santa Cruz de la Sierra Hotel
Hotel Las Américas

Hotel Las Américas

3 out of 5
Calle 21 de Mayo esq, Seoane N 356 Santa Cruz Santa Cruz Department
The price is Rp638.899 per night from 5 Dec to 6 Dec
Rp638.899
Rp638.899 total
5 Dec - 6 Dec
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and a 24-hour front desk. Popular attractions La Recova Artisan Walk and Guarani Nandereko ...
6/10 (1 review)
Hotel mediano, ótima localização
O chuveiro foi impossível tomar um.banho de qualidade

Reviewed on 29 Jul 2025

Hotel Las Américas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Stay at this business-friendly apartment in Santa Cruz. Enjoy free Wi-Fi, free parking and room service. Popular attractions Patio Design LifeStyle Center and ...
8.6/10 Excellent! (92 reviews)
Everything is perfect!!

Reviewed on 29 Oct 2025

Apart Hotel Premium Suites Santa Cruz
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Stay at this business-friendly aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
9/10 Wonderful! (78 reviews)
Great folks with there. Clean rooms.

Reviewed on 29 Aug 2025

Premium Suites Deluxe Aparthotel Equipetrol
AMERICA APARTMENTS

AMERICA APARTMENTS

3 out of 5
61 Carandí Santa Cruz Departamento de Santa Cruz
Stay at this apartment in Santa Cruz. Enjoy free Wi-Fi, laundry facilities and balconies or patios. Popular attractions Artecampo and Parque Ecológico are located ...
AMERICA APARTMENTS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

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Reviews of Santa Cruz

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