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Our top choices for Southern Illinois hotels

An outdoor patio with wicker furniture, a central table, and a view of a grassy field and trees.

1. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

Rp2.405.105 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.

2. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Mei

Rp2.271.833 total

includes taxes & fees

17 Nov - 18 Nov

A modern building with a covered entrance, large windows, and a clear sky.

3. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Kevin

Rp2.191.467 total

includes taxes & fees

11 Dec - 12 Dec

A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.

4. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Tammi

Rp2.612.026 total

includes taxes & fees

15 Nov - 16 Nov

A brick building entrance with a glass door featuring a reflective pattern and a mat with the text "MAKING YOU HAPPY MAKES US HAPPY."

5. Hampton Inn & Suites Effingham

Effingham

Scott

Rp2.550.954 total

includes taxes & fees

29 Nov - 30 Nov

A hotel lobby with a reception desk, a red sofa, a potted plant, and a fireplace.

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Paul

Rp2.252.533 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.

7. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Steve

Rp2.245.719 total

includes taxes & fees

4 Dec - 5 Dec

A bar area with a long counter, multiple bar stools, and overhead lighting.

8. Best Western Delta Inn

Effingham

Christian

Rp1.690.942 total

includes taxes & fees

29 Nov - 30 Nov

A breakfast buffet with various pastries, a bowl of oranges, and a waffle batter dispenser.

9. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

Rp1.506.646 total

includes taxes & fees

22 Nov - 23 Nov

A reception desk with a "Welcome to the Prairie State" sign, a receptionist, and a digital display.

10. Hampton Inn O'Fallon

O'Fallon

paul

Rp2.397.504 total

includes taxes & fees

22 Nov - 23 Nov

11. Comfort Inn & Suites Marion I-57

Marion

Dennis

Rp2.409.824 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a high ceiling, multiple seating areas, and a central plant.

12. Drury Inn & Suites Marion

Marion

Heather

Rp2.046.649 total

includes taxes & fees

22 Nov - 23 Nov

A modern living room with a fireplace, seating, and a television.

13. Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Marion

Jennifer

Rp2.830.700 total

includes taxes & fees

22 Nov - 23 Nov

A modern bar area with a large screen, seating, and gaming machines.

14. Walker's Bluff Casino Resort

Carterville

Ron

Rp2.519.807 total

includes taxes & fees

13 Dec - 14 Dec

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

15. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

Rp1.468.377 total

includes taxes & fees

13 Dec - 14 Dec

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

16. Best Western Plus Centralia Hotel & Suites

Centralia

Jeremy

Rp2.824.892 total

includes taxes & fees

19 Nov - 20 Nov

A hotel room with a large bathtub, a bed with a dark headboard, two bedside tables with lamps, and a mirror above the bathtub.

17. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Samantha

Rp1.780.532 total

includes taxes & fees

22 Nov - 23 Nov

18. Holiday Inn Effingham by IHG

Effingham

Penny

Rp2.246.643 total

includes taxes & fees

13 Dec - 14 Dec

A spacious lobby with a stone fireplace, a sofa, and a coffee table.

19. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

Rp1.540.643 total

includes taxes & fees

1 Dec - 2 Dec

An outdoor patio with tables and chairs, a brick building, and a parking lot in the background.

20. Fairfield Inn & Suites by Marriott O'Fallon, IL

O'Fallon

Mohamad

Rp2.891.641 total

includes taxes & fees

29 Nov - 30 Nov

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Holiday Rentals in Southern Illinois

Apartment

A wooden deck with a covered seating area, a sliding glass door, and a flag.

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

A covered porch with two blue Adirondack chairs, a ceiling fan, and a sliding glass door leading to a parking area.

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Cottage

An outdoor patio area with wooden furniture, including chairs and a table, and a fire pit.

Country Home Near EIU & Lake Charleston!

Charleston

"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...

Cottage

A modern kitchen with dark cabinets, a round dining table, and a tufted bench.

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

"The hosts were fantastic about working with us on our check-in time, since we were on time commitment. The house was in a great location. The interior was perfect for our needs. Nick responded immediately when I had a question. Very friendly. I will definitely stay here again if my family ever returns Robinson!"

Cottage

A spacious living room with leather sofas, a dining table, and a ceiling fan.

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

A narrow hallway with wooden flooring, white doors, and a window with blinds.

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

A wooden deck with a ceiling fan, outdoor furniture, and a view of a garden.

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

Comfort Suites Mount Vernon

10/10 Excellent

"Great handicap room. Breakfast"

Best Western St. Louis Fairview Heights

8/10 Good

"Much better than I expected for the price. Very quite and I had a great sleep. The room was dark and the bed was firm and comfortable. The shower head had plenty of pressure which was nice. I also was pleased with the breakfast selection. Yes, like other older hotels under new ownership, the place lacked attention to details, but for the price and location I recommend staying here."

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

Rp941.026

Rp1.081.991 total

23 Nov - 24 Nov

includes taxes & fees

6.6/10 (1,163 reviews)

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Our top choices for Southern Illinois hotels

1. Comfort Suites Mount Vernon

2. Drury Plaza Hotel Mt. Vernon

3. Holiday Inn Express & Suites Mount Vernon by IHG

4. DoubleTree by Hilton Mt. Vernon

5. Hampton Inn & Suites Effingham

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

7. La Quinta Inn & Suites by Wyndham Effingham

8. Best Western Delta Inn

9. Super 8 by Wyndham Mt. Vernon IL

10. Hampton Inn O'Fallon

11. Comfort Inn & Suites Marion I-57

12. Drury Inn & Suites Marion

13. Holiday Inn Express Hotel & Suites Marion Northeast by IHG

14. Walker's Bluff Casino Resort

15. Quality Inn Mount Vernon, IL

16. Best Western Plus Centralia Hotel & Suites

17. Country Inn & Suites by Radisson, Effingham, IL

18. Holiday Inn Effingham by IHG

19. SureStay Hotel by Best Western Whittington Rend Lake

20. Fairfield Inn & Suites by Marriott O'Fallon, IL

Holiday Rentals in Southern Illinois

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

Learn more about Southern Illinois

Top Southern Illinois Hotel Reviews

Comfort Suites Mount Vernon

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

Explore a world of travel with Expedia

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