Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Southern Minnesota hotels

An indoor swimming pool with a curved design, surrounded by palm trees and a white pool ladder.

1. Treasure Island Resort & Casino

Welch

Jacob

Rp1.997.144 total

includes taxes & fees

12 Nov - 13 Nov

A hotel lobby with a reception desk, a coffee station, and a seating area with tables and chairs.

2. AmericInn by Wyndham Mankato Event Center

Mankato

Brian

Rp1.583.075 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel lobby with a dining area, seating arrangements, and a stone fireplace.

3. Fairfield Inn & Suites by Marriott Winona

Winona

Leanne

Rp2.703.684 total

includes taxes & fees

22 Nov - 23 Nov

A hotel lobby with a reception desk, seating area, and artwork on the walls.

4. Holiday Inn Express & Suites Worthington by IHG

Worthington

Kirsten

Rp2.082.729 total

includes taxes & fees

15 Nov - 16 Nov

A modern American Inn by Wyndham with a parking lot and a clear sky.

5. AmericInn By Wyndham Mountain Lake Mn

Mountain Lake

Misty

Rp2.513.447 total

includes taxes & fees

18 Nov - 19 Nov

A modern dining area with high tables, chairs, and pendant lighting.

6. Hampton Inn & Suites Rochester-North

Rochester

Mark

Rp2.029.067 total

includes taxes & fees

28 Nov - 29 Nov

A courtyard with rows of white chairs and tables, a pool, and a Marriott hotel building in the background.

7. Courtyard Mankato Marriott

Mankato

John

Rp1.964.574 total

includes taxes & fees

22 Nov - 23 Nov

A spacious indoor pool area with multiple levels, a hot tub, and a seating area with tables and chairs.

8. Best Western Plus New Ulm

New Ulm

Betsy

Rp2.382.922 total

includes taxes & fees

25 Nov - 26 Nov

A Comfort Inn & Suites building with a covered entrance, numbered 2000, and a parking lot with cars.

9. Comfort Inn & Suites North Mankato

Mankato

Jeffrey

Rp1.780.733 total

includes taxes & fees

6 Dec - 7 Dec

A hotel with outdoor seating and a fire pit.

10. Country Inn & Suites by Radisson, Mankato Hotel and Conference Center, MN

Mankato

Bridget

Rp1.972.984 total

includes taxes & fees

6 Dec - 7 Dec

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

11. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Joseph

Rp1.484.683 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

12. AmericInn by Wyndham Winona

Winona

Jonathan

Rp2.696.830 total

includes taxes & fees

4 Dec - 5 Dec

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

13. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Robert Blaise

Rp2.312.280 total

includes taxes & fees

27 Nov - 28 Nov

A swimming pool with a tiled edge, a lifeguard stand, and a seating area with chairs and tables.

14. Holiday Inn Express Hotel and Suites Mankato East by IHG

Mankato

Dale

Rp1.942.749 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

15. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

Rp2.315.398 total

includes taxes & fees

29 Nov - 30 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

16. Hampton Inn Rochester-South

Rochester

Susan

Rp2.014.927 total

includes taxes & fees

12 Dec - 13 Dec

A modern indoor patio with a fire feature, seating, and large windows.

17. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

Ashley

Rp2.614.563 total

includes taxes & fees

26 Nov - 27 Nov

A modern restaurant with a central counter, seating area, and a clock on the wall.

18. Best Western Plus Albert Lea I-90/I-35 Hotel

Albert Lea

Patricia

Rp1.674.709 total

includes taxes & fees

29 Nov - 30 Nov

A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

19. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

LeeAnn

Rp1.562.037 total

includes taxes & fees

11 Dec - 12 Dec

An outdoor patio area with tables and chairs, a brick building labeled "St. James Hotel" in the background, and a clear sky.

20. St James Hotel, a Historic Hotel of America

Red Wing

Daniel

Rp2.801.055 total

includes taxes & fees

16 Nov - 17 Nov

View all properties

Holiday Rentals in Southern Minnesota

Aparthotel

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

The Berkman

Folwell

"Excellent service and wonderful room!"

Apartment

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester

"Clean room and great location"

Apartment

A wooden interior with a kitchen, bar area, and a staircase.

Lake Pepin Escape: Loft Cottage & Fireplace

Pepin

"Great location and very well furnished with new appliances."

Apartment

A bedroom with a bed, a chair, a table, a fireplace, and a ceiling fan.

Pet-friendly Wabasha Studio: Boat, Ski & Explore!

Wabasha

"Great property! Very convenient location as well."

Apartment

A modern kitchen with a central island, bar stools, and a large window.

1 Block to Lake City Marina: Condo w/ Rooftop Deck

Lake City

"Wonderful property, spacious, well-appointed and comfortable. Would definitely rent again."

Apartment

A two-story building with a green exterior, a covered porch, and a driveway leading to a garage.

Downtown Northfield Apt: Winter Walk & Shops

Northfield

"It was amazing!"

Cottage

A kitchen with wooden cabinets, a granite countertop, a refrigerator, and bar stools.

Lake City Retreat Near Wineries & State Park

Lake City

Cottage

A modern interior with a stone fireplace, wooden walls, a leather sofa, and a dining area.

Pet-friendly Cabin Retreat: Walk to Lake Pepin!

Pepin

"What a fun place! Plenty of room. We played foosball had a fire outside. We enjoyed the fireplace too. We hadn’t anticipated no TV though. You might want to add that to your description. The water is definitely smelly, so we truly appreciated the 40 bottles of water you provided. Definitely a great place for a girl’s weekend or family reunion!"

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Southern Minnesota attractions

Mayo Civic Center

9.2/10 (818 reviews)

Catch an event at Mayo Civic Center during your trip to Rochester. Attend a sporting event or simply visit the area's shops.

See properties

Learn more about Southern Minnesota

Explore the family-friendly area of Southern Minnesota—an opera house, shopping and sights from Mount Kato Ski Area to Blakeslee Stadium.

See all hotels in Southern Minnesota

A lake surrounded by dense forest and a distant hill with a fort.

Top Southern Minnesota Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"Great location and nice and comfy rooms"

Hyatt House Rochester/Mayo Clinic Area

8/10 Good

"Stay was as usual. The property has been sold to new owners, resulting in some changes. 1) They now charge for parking- $20 per night. It didn’t get charged earlier. But they now restrict access to parking via room keys so hopefully vehicles are safer. 2) Saw an upgrade in breakfast- it was visibly better from how it used to be earlier. 3) Room was the same, albeit saw water blockage in the sink- housekeeping needs better controls. All in all, will recommend the property- it’s walking distance from Meyo; you can also take a shuttle. Courteous staff; good pricing, comfortable rooms and convenient location."

St James Hotel, a Historic Hotel of America

10/10 Excellent

"Great stay. The room was fantastic, we did room service for supper something I never do. It was at our door in no time after ordering. The food was very reasonable and very satisfying. If or looking for a quick getaway to Red Wing you can't beat the St James."

More cheap stays in Southern Minnesota

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

Rp1.083.720

Rp1.231.377 total

3 Dec - 4 Dec

includes taxes & fees

Explore a world of travel with Expedia

More ways to book

Book Hotels in Southern Minnesota on Expedia.com

Find hotels in Southern Minnesota, MN from Rp1.231.377

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southern Minnesota

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Southern Minnesota hotels

1. Treasure Island Resort & Casino

2. AmericInn by Wyndham Mankato Event Center

3. Fairfield Inn & Suites by Marriott Winona

4. Holiday Inn Express & Suites Worthington by IHG

5. AmericInn By Wyndham Mountain Lake Mn

6. Hampton Inn & Suites Rochester-North

7. Courtyard Mankato Marriott

8. Best Western Plus New Ulm

9. Comfort Inn & Suites North Mankato

10. Country Inn & Suites by Radisson, Mankato Hotel and Conference Center, MN

11. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

12. AmericInn by Wyndham Winona

13. Hyatt House Rochester/Mayo Clinic Area

14. Holiday Inn Express Hotel and Suites Mankato East by IHG

15. Home2 Suites by Hilton Rochester Mayo Clinic Area

16. Hampton Inn Rochester-South

17. EVEN Hotel Rochester - Mayo Clinic Area by IHG

18. Best Western Plus Albert Lea I-90/I-35 Hotel

19. Comfort Inn & Suites Rochester South Mayo Clinic

20. St James Hotel, a Historic Hotel of America

Holiday Rentals in Southern Minnesota

The Berkman

Stay near popular Southern Minnesota attractions

Mayo Civic Center

Learn more about Southern Minnesota

Top Southern Minnesota Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

More cheap stays in Southern Minnesota

Super 8 by Wyndham Winona MN

Explore a world of travel with Expedia

Go further with the Expedia app