Downtown Clayton Travel Guide
St. Louis
Visit Downtown Clayton
Popular places to visit
St. Louis Union Station
You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Dome at America’s Center
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and great live music.
Things to do
Downtown St. Louis Smartphone Guided Audio Walking Tour App
Saint Louis Self Guided Driving and Walking Audio Tour
Gateway Arch National Park Self Guided Audio Walking Tour
An Epic Scavenger Hunt: Gateway to the West
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
Top hotels in Downtown Clayton
Clayton Plaza Hotel & Extended Stay
Comfortable. Excellent staff.
Reviewed on 18 Feb 2026
The Ritz-Carlton, St. Louis
Excellent hotel with various restaurants and expansive lobby area.. staff very attentive.
Reviewed on 6 Feb 2026
Le Méridien St. Louis Clayton
I cancellled they Exp
Reviewed on 4 Feb 2026
AC Hotel St. Louis Clayton
Front desk staff was excellent. Good service at the bar. Gentleman at the valet desk was inattentive and disappointing - and that was after I tipped him.
Reviewed on 15 Feb 2026
21C Museum Hotel St Louis
Pleasant staff
Reviewed on 17 Feb 2026
Pear Tree Inn St. Louis Airport
Check Downtown Clayton hotel availability
Other neighbourhoods around Downtown Clayton
Clayton
Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.
University City
Noted for its shopping and restaurants, there's plenty to explore in University City. Top attractions like Museum of Transportation and Center of Creative Arts are major draws, and you can hop on the metro at Forsyth Station or U City Big Bend Station to see more of the city.
Ladue
Ladue is well liked for its restaurants and churches. If you're hoping to see more of the larger area, Saint Louis Galleria Mall and St. Louis Art Museum are some interesting sights nearby to check out.
Dogtown
When in Dogtown, you can plan a visit to St. Louis Zoo and St. Louis Art Museum, some noteworthy sights in the nearby area.
The Hill
While The Hill isn't home to many top sights, St. Louis Science Center and Missouri Botanical Gardens and Arboretum are some notable places to visit nearby.
Central West End
If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.
