Find hotels in Defiance, MO from Rp1.133.229

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top 10 Defiance hotels and places to stay

Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (832)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is Rp1.831.280
Rp2.197.453 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
9.8 out of 10, Exceptional, (16)
"Very nice:) "
United States
Alicia
The price is Rp1.231.952
Rp1.416.129 total
includes taxes & fees
8 Dec - 9 Dec
WoodSpring Suites St Peters-OFallon
Ballroom
The Wildwood Hotel

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1600)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
The Wildwood Hotel
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very good, (1004)
"Great breakfast, clean room, hot tub!"
United States
Tony
The price is Rp1.451.706
Rp1.668.296 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn St. Charles St. Peters
Courtyard
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3.0 star property
Maryland Heights
7.4 out of 10, Good, (1003)
"Friendly staff "
United States
Keyona
The price is Rp1.066.804
Rp1.237.364 total
includes taxes & fees
5 Jan - 6 Jan 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very good, (1029)
"Very friendly staff "
United States
Amber
The price is Rp1.415.080
Rp1.634.501 total
includes taxes & fees
14 Dec - 15 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Front of property – evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2208)
"Decent room. Well priced and centrally located for out soccer tournament we were in town for"
United States
Travis
The price is Rp1.619.850
Rp2.131.264 total
includes taxes & fees
28 Dec - 29 Dec
Hollywood Casino & Hotel St. Louis
BBQ/picnic Area
Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (575)
"Very clean hotel with great staff "
United States
brad
The price is Rp1.781.336
Rp2.072.815 total
includes taxes & fees
20 Dec - 21 Dec
Courtyard by Marriott St. Louis Chesterfield
Lobby
Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
O'Fallon
7.6 out of 10, Good, (1000)
"Great front desk experience, no issues booking same day!"
United States
Tracy
The price is Rp1.201.320
Rp1.416.956 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites St. Louis - O'Fallon
Reception
Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville

2.5 star property
Wentzville
9.0 out of 10, Wonderful, (638)
"The room was clean and quiet The staff was very nice the temperature was perfect"
United States
candice
The price is Rp1.984.442
Rp2.271.287 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hampton Inn St. Louis Wentzville
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (830)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is Rp1.381.784
Rp1.629.814 total
includes taxes & fees
11 Dec - 12 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG
Front of property
Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1000)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
The price is Rp1.012.198
Rp1.179.089 total
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Eureka/Six Flags Nearby
Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is Rp1.259.921
Rp1.445.445 total
includes taxes & fees
12 Dec - 13 Dec
Baymont by Wyndham Warrenton
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1002)
"Nice breakfast, friendly staff"
United States
Damon
The price is Rp1.453.370
Rp1.714.251 total
includes taxes & fees
9 Dec - 10 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive
Lobby sitting area
Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
O'Fallon
8.8 out of 10, Excellent, (714)
"Clean room, quiet"
United States
Laura
The price is Rp1.448.542
Rp1.717.608 total
includes taxes & fees
22 Dec - 23 Dec
Hilton Garden Inn St. Louis/O'Fallon MO
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1003)
"Love this hotel. "
United States
Lisa
The price is Rp1.923.177
Rp2.210.249 total
includes taxes & fees
1 Jan - 2 Jan 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Lobby
Quality Inn

Quality Inn

2.5 star property
Foristell
8.2 out of 10, Very good, (903)
"Easy check in and out, the staff is very nice and professional. I would stay there any time Im in the area and need a room. Highly recommended."
United States
Ivaylo
The price is Rp1.393.438
Rp1.573.889 total
includes taxes & fees
14 Dec - 15 Dec
Quality Inn
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

2.5 star property
St. Charles
8.4 out of 10, Very good, (1003)
"Nice staff at reception. "
United States
Denise
The price is Rp1.465.024
Rp1.683.707 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Suites St Charles - St Louis
Exterior
Best Western Plus Fenton

Best Western Plus Fenton

2.5 star property
Fenton
9.2 out of 10, Wonderful, (168)
"Clean room, nice staff, great food, and great service "
United States
Thuy
The price is Rp1.765.021
Rp2.038.388 total
includes taxes & fees
9 Dec - 10 Dec
Best Western Plus Fenton
Indoor pool
Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG

3.0 star property
Eureka
9.0 out of 10, Wonderful, (1002)
"Great place to stay"
United States
John
The price is Rp1.797.984
Rp2.094.436 total
includes taxes & fees
15 Dec - 16 Dec
Holiday Inn St. Louis West Six Flags by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties
Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Very nice rodeo suite. I would recommend."
Jon 1-night trip
Posted 5 days ago
Hollywood Casino & Hotel St. Louis

More cheap stays in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is Rp1.048.824 per night from 8 Dec to 9 Dec
Rp1.048.824
Rp1.205.315 total
8 Dec - 9 Dec
includes taxes & fees
6.4/10 (999 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hollywood Casino & Hotel St. Louis and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Explore a world of travel with Expedia