Mesopotamia Travel Guide

Tourist Guide

Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
The price is Rp2.148.625 per night from 28 Apr to 29 Apr
Rp2.148.625
Rp2.148.625 total
28 Apr - 29 Apr
Stay at this luxury hotel in Corrientes. Enjoy a steam room. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
10/10 Exceptional! (26 reviews)
Todo excelente

Reviewed on 14 Apr 2026

Marriott Corrientes Hotel
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
The price is Rp696.154 per night from 23 Apr to 24 Apr
Rp696.154
Rp696.154 total
23 Apr - 24 Apr
Stay at this hotel in Gualeguaychú. Enjoy free Wi-Fi, a 24-hour front desk and a business centre. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.6/10 Good! (82 reviews)
Yes, it was good, well maintained and quiet.

Reviewed on 3 Apr 2026

O2 Hotel Gualeguaychú
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
The price is Rp931.128 per night from 22 Apr to 23 Apr
Rp931.128
Rp1.120.207 total
22 Apr - 23 Apr
Stay at this business-friendly hotel in Concordia. Enjoy free breakfast, free Wi-Fi and room service. Popular attractions Concordia Golf Course and Castillo ...
8.6/10 Excellent! (377 reviews)
AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road.

Reviewed on 22 Dec 2025

Hathor Concordia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Complejo La Loma

Complejo La Loma

3 out of 5
Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos
Stay at this aparthotel in Federacion. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ...
8.4/10 Very Good! (6 reviews)
Great self-contained suite!
Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on 9 Sept 2023

Complejo La Loma
Totoras Apart Federacion

Totoras Apart Federacion

2.5 out of 5
Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios
Stay at this aparthotel in Federacion. Enjoy free Wi-Fi, free parking and room service. Popular attractions Termas de Federacion and Termas Federacion Water ...
Totoras Apart Federacion
Agustín 1 Apart

Agustín 1 Apart

4 out of 5
130 Gral. Pedro Ferré Parana Entre Ríos
Stay at this aparthotel in Parana. Enjoy free Wi-Fi, parking (surcharge) and on-site spa services. Popular attractions Plaza de Mayo and Museu De Sitio are located ...
8.8/10 Excellent! (5 reviews)
Everything about the place was great. Our only complaint was that the kettle didn't heat water so it was hard to make mate.

Reviewed on 28 Feb 2026

Agustín 1 Apart
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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