Mesopotamia Travel Guide

Tourist Guide

Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
The price is Rp2.235.125 per night from 18 Jun to 19 Jun
Rp2.235.125
Rp2.235.125 total
18 Jun - 19 Jun
Stay at this luxury hotel in Corrientes. Enjoy a steam room. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
10/10 Exceptional! (32 reviews)
"Un hotel muy bien ubicado con unas vistas preciosas al río y su costanera."

Reviewed on 21 May 2026

Marriott Corrientes Hotel
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
The price is Rp569.331 per night from 28 Jun to 29 Jun
Rp569.331
Rp569.331 total
28 Jun - 29 Jun
Stay at this hotel in Corrientes. Enjoy free breakfast, free Wi-Fi and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ...
9/10 Wonderful! (7 reviews)
"The best place to stay in Corrientes! Amazing views"

Reviewed on 7 Apr 2026

Turismo Hotel Casino
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
The price is Rp724.180 per night from 3 Jun to 4 Jun
Rp724.180
Rp724.180 total
3 Jun - 4 Jun
Stay at this hotel in Gualeguaychú. Enjoy free Wi-Fi, a 24-hour front desk and a business centre. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.6/10 Good! (83 reviews)
"Yes, it was good, well maintained and quiet."

Reviewed on 3 Apr 2026

O2 Hotel Gualeguaychú
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Club Valle Termal Resort

Club Valle Termal Resort

3 out of 5
Ñandubay S/N, Corner Coronel Salas Federacion Entre Rios
Stay at this family-friendly hotel in Federacion. Enjoy free breakfast, free Wi-Fi and room service. Popular attractions Termas de Federacion and Termas Federacion ...
9.2/10 Wonderful! (94 reviews)
"La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto."

Reviewed on 18 Nov 2025

Club Valle Termal Resort
Agustín 1 Apart

Agustín 1 Apart

3.5 out of 5
130 Gral. Pedro Ferré Parana Entre Ríos
Stay at this apartment in Parana. Enjoy free Wi-Fi, parking (surcharge) and on-site spa services. Popular attractions Plaza de Mayo and Museu De Sitio are located ...
8.8/10 Excellent! (5 reviews)
"Everything about the place was great. Our only complaint was that the kettle didn't heat water so it was hard to make mate."

Reviewed on 28 Feb 2026

Agustín 1 Apart
Donsuites Apart Hotel

Donsuites Apart Hotel

3 out of 5
La Rioja 442 Corrientes Corrientes
Stay at this aparthotel in Corrientes. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ...
Donsuites Apart Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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