Mesopotamia Travel Guide

Tourist Guide

Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia
Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
The price is Rp2.208.500 per night from 17 Jun to 18 Jun
Rp2.208.500
Rp2.208.500 total
17 Jun - 18 Jun
Stay at this luxury hotel in Corrientes. Enjoy a steam room. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
10/10 Exceptional! (28 reviews)
"Great"

Reviewed on 22 Apr 2026

Marriott Corrientes Hotel
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
Fully refundableReserve now, pay when you stay
The price is Rp2.118.517 per night from 15 Jun to 16 Jun
Rp2.118.517
Rp2.118.517 total
15 Jun - 16 Jun
Stay at this hotel in Corrientes. Enjoy free breakfast, free Wi-Fi and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ...
9/10 Wonderful! (7 reviews)
"The best place to stay in Corrientes! Amazing views"

Reviewed on 7 Apr 2026

Turismo Hotel Casino
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros Colon Entre Rios
The price is Rp2.067.156 per night from 21 May to 22 May
Rp2.067.156
Rp2.067.156 total
21 May - 22 May
Stay at this spa hotel in Colon. Enjoy free breakfast, free Wi-Fi and an outdoor pool. Popular attractions Dr. Herminio J. Quiros Park and Termas De Colón are ...
8.8/10 Excellent! (63 reviews)
Motel masquerading as a SPA Hotel
"Short Version See pictures for detailed information) - Rooms and bathrooms are small, shower already tight spaced with doors that don’t close properly. - By day 3, construction noise and chemicals smells from remodeling work became a big issue. - Receptionist did not offer solutions and lied about ..."

Reviewed on 12 Sept 2025

Costarenas Hotel & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Complejo La Loma

Complejo La Loma

3 out of 5
Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos
Stay at this aparthotel in Federacion. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ...
8.4/10 Very Good! (6 reviews)
Great self-contained suite!
"Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ..."

Reviewed on 9 Sept 2023

Complejo La Loma
Donsuites Apart Hotel

Donsuites Apart Hotel

3 out of 5
La Rioja 442 Corrientes Corrientes
Stay at this aparthotel in Corrientes. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ...
Donsuites Apart Hotel
Club Valle Termal Resort

Club Valle Termal Resort

3 out of 5
Ñandubay S/N, Corner Coronel Salas Federacion Entre Rios
Stay at this family-friendly hotel in Federacion. Enjoy free breakfast, free Wi-Fi and room service. Popular attractions Termas de Federacion and Termas Federacion ...
9.2/10 Wonderful! (94 reviews)
"La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto."

Reviewed on 18 Nov 2025

Club Valle Termal Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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