Mesopotamia Travel Guide

Tourist Guide

Mesopotamia showing a river or creek and forests
Mesopotamia showing a river or creek and forests
Mesopotamia showing forest scenes
Foz do Iguaçu which includes bird life
Mesopotamia featuring a river or creek and forests

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
The price is Rp2.407.548 per night from 27 Feb to 28 Feb
Rp2.407.548
Rp2.407.548 total
27 Feb - 28 Feb
Stay at this luxury hotel in Corrientes. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
9.8/10 Exceptional! (21 reviews)
Fantastic stay. Room was immaculate and hotel staff were very friendly and helpful. Great pool and beds were super comfortable.

Reviewed on 6 Feb 2026

Marriott Corrientes Hotel
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
The price is Rp757.620 per night from 18 Feb to 19 Feb
Rp757.620
Rp757.620 total
18 Feb - 19 Feb
Stay at this hotel in Gualeguaychú. Enjoy free Wi-Fi, a 24-hour front desk and a business centre. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.6/10 Good! (70 reviews)
La limpieza de los cuartos necesita mejorar. También agregar servicios básicos como TV y teléfono en los cuartos

Reviewed on 12 Mar 2025

O2 Hotel Gualeguaychú
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
The price is Rp1.888.999 per night from 1 Mar to 2 Mar
Rp1.888.999
Rp1.888.999 total
1 Mar - 2 Mar
Stay at this hotel in Corrientes. Enjoy free breakfast, free Wi-Fi and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ...
8/10 Very Good! (4 reviews)
Boa infraestrutura, e localização!

Reviewed on 4 Feb 2026

Turismo Hotel Casino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Complejo La Loma

Complejo La Loma

3 out of 5
Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos
Stay at this aparthotel in Federacion. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ...
7.6/10 Good! (4 reviews)
Great self-contained suite!
Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on 9 Sept 2023

Complejo La Loma
Totoras Apart Federacion

Totoras Apart Federacion

2.5 out of 5
Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios
Stay at this aparthotel in Federacion. Enjoy free Wi-Fi, free parking and room service. Popular attractions Termas de Federacion and Termas Federacion Water ...
7.4/10 Good! (27 reviews)
Nada en particular, es buena la relación precio prestación.

Reviewed on 3 Jan 2026

Totoras Apart Federacion
Donsuites Apart Hotel

Donsuites Apart Hotel

3 out of 5
La Rioja 442 Corrientes Corrientes
Stay at this aparthotel in Corrientes. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ...
8.6/10 Excellent! (105 reviews)
Loved this place, super clean, and the staff were very nice and helpful😍

Reviewed on 30 Aug 2024

Donsuites Apart Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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