Santa Cruz Travel Guide

Tourist Guide

A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.
A historic church with two prominent towers, a plaza with people, and a sunset in the background.
A historic building with a clock tower and a white building with balconies.
A historic church with two towers, surrounded by a plaza with palm trees and a white building with a red roof.
A lush green landscape with a dense forest, rolling hills, and a small body of water.

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Equipetrol

When in Equipetrol, you can plan a visit to Santa Cruz Zoo and Municipal Library, some noteworthy sights in the nearby area.

Centro Histórico

If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.

Hamacas

When in Hamacas, you can plan a visit to Las Brisas Shopping Center and Santa Cruz Zoo, some noteworthy sights in the nearby area.

Zona Sur (South Zone)

Though Zona Sur (South Zone) may not have many top sights, you can venture to the surrounding area to see attractions like Ramon Tahuichi Aguilera Stadium and Plaza 24 de Septiembre.

Urubó

While there might not be top attractions in Urubó, you can explore the larger area and discover places like Guembe Biocenter and Ventura Mall.

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is Rp761.740 per night from 4 Dec to 5 Dec
Rp761.740
Rp761.740 total
4 Dec - 5 Dec
Stay at this business-friendly hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. ...
Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is Rp2.751.633 per night from 16 Nov to 17 Nov
Rp2.751.633
Rp2.751.633 total
16 Nov - 17 Nov
Stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...
9/10 Wonderful! (426 reviews)
"Beautiful hotel with so many things to explore. Pools and surrounding area are clean and well maintained. Staff are friendly and they are always around and so helpful. Room was exceptionally clean. The beautiful balcony leading out to the garden is just incredible. Breakfast was also incredible. ..."

Reviewed on 8 Nov 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
Fully refundable
The price is Rp2.075.713 per night from 28 Nov to 29 Nov
Rp2.075.713
Rp2.075.713 total
28 Nov - 29 Nov
Stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa and a rooftop terrace. Our guests praise the helpful staff in their reviews. ...
9/10 Wonderful! (261 reviews)
"Beautiful views and clean property. The food there is great, and it’s well located. However, the cleaning staff stole a $100 bill from my backpack and replaced it with a fake one. I would rather they just took the money, but replacing it with a fake note could’ve gotten me in serious trouble, and ..."

Reviewed on 30 Oct 2026

Marriott Santa Cruz de la Sierra Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Stay at this business-friendly apartment in Santa Cruz. Enjoy free Wi-Fi, free parking and room service. Popular attractions Patio Design LifeStyle Center and ...
8.6/10 Excellent! (107 reviews)
"Book at the hotel and they will take you in to different place. Building entrance key doesn't work most of the time. Very hard to take transportation to and to the place. Male attendants were very friendly and helpful. And many more small details."

Reviewed on 6 Oct 2026

Apart Hotel Premium Suites Santa Cruz
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Stay at this business-friendly aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
Premium Suites Deluxe Aparthotel Equipetrol
AMERICA APARTMENTS

AMERICA APARTMENTS

3 out of 5
61 Carandí Santa Cruz Departamento de Santa Cruz
Stay at this apartment in Santa Cruz. Enjoy free Wi-Fi, laundry facilities and balconies or patios. Popular attractions Artecampo and Parque Ecológico are located ...
10/10 Exceptional! (3 reviews)
"Clean room, great staff"

Reviewed on 10 Feb 2026

AMERICA APARTMENTS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

Things to do