Santa Cruz Travel Guide

Tourist Guide

A colonial-style building with a bell tower, palm trees, and a paved walkway.
A brick building with arched windows and a spiral design on the facade.
A historic building with columns and flags, palm trees, and a clear blue sky.
Santa Cruz
A historic church with two bell towers and a central facade.

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Ventura Mall, some noteworthy sights in the nearby area.

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is Rp959.233 per night from 14 Jul to 15 Jul
Rp959.233
Rp959.233 total
14 Jul - 15 Jul
Stay at this business-friendly hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. ...
9.4/10 Exceptional! (124 reviews)
"Good location and value for money."

Reviewed on 23 May 2026

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
Fully refundable
The price is Rp2.348.739 per night from 1 Jul to 2 Jul
Rp2.348.739
Rp2.348.739 total
1 Jul - 2 Jul
Stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on 29 May 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is Rp2.396.467 per night from 12 Jul to 13 Jul
Rp2.396.467
Rp2.396.467 total
12 Jul - 13 Jul
Stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa and a rooftop terrace. Our guests praise the helpful staff in their reviews. ...
9/10 Wonderful! (236 reviews)
"The room was too cold and the last day there was no hot water for the shower."

Reviewed on 13 Jun 2026

Marriott Santa Cruz de la Sierra Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Stay at this business-friendly aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
9/10 Wonderful! (108 reviews)
"We had a great stay with our family. It was fitting for our needs!"

Reviewed on 25 Jun 2026

Premium Suites Deluxe Aparthotel Equipetrol
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Stay at this business-friendly apartment in Santa Cruz. Enjoy free Wi-Fi, free parking and room service. Popular attractions Patio Design LifeStyle Center and ...
8.6/10 Excellent! (102 reviews)
"Great location."

Reviewed on 4 Jun 2026

Apart Hotel Premium Suites Santa Cruz
Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

2.5 out of 5
Equipetrol Santa Cruz Departamento de Santa Cruz
Stay at this business-friendly aparthotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and a 24-hour front desk. Popular attractions Centro Cultural San Isidro ...
Equipetrol Suites Apart Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

Things to do