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2 Oct - 4 Oct
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9 Oct - 11 Oct

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Our top choices for Isle of Palms South hotels

A hotel lobby with a bar area, seating arrangements, and a reception desk.

1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place to stay."
United States
Patsy
The price is Rp1.957.721
Rp2.222.014 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A modern restaurant with a bar area, wooden ceiling, and large windows.

2. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
1.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (365 reviews)
"Very nice stay!"
United States
Patricia
The price is Rp3.038.949
Rp3.449.207 total
includes taxes & fees
17 Oct - 18 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (603 reviews)
"Great stay"
United States
Michaelanne
The price is Rp2.456.132
Rp2.787.710 total
includes taxes & fees
18 Oct - 19 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A lobby with a reception desk, seating area, and a staircase.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,000 reviews)
"wonderful breakfast and friendly staff"
United States
frances
The price is Rp1.742.702
Rp1.977.967 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

5. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
8.8 out of 10, Excellent, (4,539 reviews)
"Great location with beautiful views, clean, beautiful rooms and lots to do around the area"
United States
Keisha
The price is Rp2.467.716
Rp2.800.857 total
includes taxes & fees
1 Nov - 2 Nov
Margaritaville Jacksonville Beach
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

6. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (661 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
The price is Rp2.137.954
Rp2.426.578 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

7. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
1.5 km from Isle of Palms South
8.4 out of 10, Very good, (798 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
The price is Rp2.730.832
Rp3.099.494 total
includes taxes & fees
10 Oct - 11 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

8. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (589 reviews)
"Nice lodging a block from the beach. Great food nearby."
United States
Nick
The price is Rp2.587.104
Rp2.936.363 total
includes taxes & fees
26 Oct - 27 Oct
Element by Marriott Jacksonville Beach
A terrace with wooden tables and chairs, overlooking a beach and a pier.

9. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
Oceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (805 reviews)
"Excellent room and customer service."
United States
MELISSA
The price is Rp3.115.304
Rp3.535.870 total
includes taxes & fees
25 Oct - 26 Oct
Springhill Suites By Marriott Jacksonville Beach Oceanfront
A beach with a sandy shore, waves, and buildings in the background.

10. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,002 reviews)
"Big room, clean, great breakfast, right on the beach, staff is friendly."
United States
Svetlana
The price is Rp2.333.422
Rp2.648.433 total
includes taxes & fees
4 Oct - 5 Oct
Best Western Oceanfront
A covered entrance with a dark tiled floor, white columns, and a green bench.

11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,236 reviews)
"Room was clean, staff were very pleasant and helpful. Will definitely stay here again when I come back to Jacksonville."
United States
Robert
The price is Rp2.112.758
Rp2.397.980 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Pool

12. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
Oceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,000 reviews)
"Awesome stay"
United States
Susan
The price is Rp3.038.949
Rp3.449.207 total
includes taxes & fees
26 Oct - 27 Oct
Four Points by Sheraton Jacksonville Beachfront
A modern dining area with wooden tables and chairs, pendant lighting, and artwork on the walls.

13. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (987 reviews)
"clean room nice beach location"
United States
Anne
The price is Rp2.428.105
Rp2.755.899 total
includes taxes & fees
8 Oct - 9 Oct
Fairfield Inn & Suites by Marriott Jacksonville Beach
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

14. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"Great place to stay"
United States
Bobby
The price is Rp2.048.124
Rp2.324.620 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express Jacksonville Beach by IHG
A balcony with a view of the beach, a wooden walkway, and a chair.

15. Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.4 out of 10, Very good, (1,002 reviews)
"Great accommodations."
United States
John
The price is Rp2.967.444
Rp3.368.049 total
includes taxes & fees
13 Oct - 14 Oct
Courtyard by Marriott Jacksonville Beach Oceanfront
A white building with a red-tiled roof, a covered patio area, and a view of the ocean.

16. Casa Marina Hotel

Casa Marina Hotel
3.0 star property
Oceanfront, 4.8 km from Isle of Palms South
8.4 out of 10, Very good, (1,001 reviews)
"Everything was good, personnel was nice an helpful the place is close to a nice area"
United States
Jimmy
The price is Rp2.910.492
Rp3.303.409 total
includes taxes & fees
13 Oct - 14 Oct
Casa Marina Hotel
A hotel room with a large bed, a desk with a chair, a television, and a mirror.

17. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (1,000 reviews)
"Great Hotel"
United States
Josh
The price is Rp1.491.178
Rp1.692.487 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Jacksonville E 295 Baymeadows by IHG
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

18. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (219 reviews)
"Very nice stay, they have grab and go breakfast as complimentary."
United States
Phi
The price is Rp1.976.260
Rp2.243.055 total
includes taxes & fees
31 Oct - 1 Nov
Hyatt Studios Jacksonville/St Johns Town Center
A beach view with a long stretch of sand, a pier, and a residential area with houses and a swimming pool.

19. Dune House Hotel & Spa

Dune House Hotel & Spa
4.5 star property
6.8 km from Isle of Palms South
8.8 out of 10, Excellent, (1,001 reviews)
"I love this place! Definitely will be back."
United States
Kelly
The price is Rp3.571.838
Rp4.826.575 total
includes taxes & fees
11 Oct - 12 Oct
Dune House Hotel & Spa
An outdoor patio area with wicker furniture, a fire feature, and string lights.

20. Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,002 reviews)
"Good location, clean"
United States
Kerrie
The price is Rp2.195.086
Rp2.491.422 total
includes taxes & fees
16 Oct - 17 Oct
Sheraton Jacksonville Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A sunset over a beach with fallen trees and a distant shoreline.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms South Hotel Reviews

Weekly Inn

Weekly Inn

10/10 Excellent
"The place was excellent it was clean the only thing I will say is they need to upgrade their pillows and mattress other than that it was phenomenal for the price"
Wayne 3-night trip
Posted 4 hours ago
Weekly Inn

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.