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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
Rp2.447.519
Rp2.777.934 total
includes taxes & fees
31 Oct - 1 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.
An outdoor patio with a pool, wooden pergola, and seating area.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
Rp2.202.069
Rp2.499.348 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

3. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
Rp3.028.292
Rp3.437.112 total
includes taxes & fees
24 Oct - 25 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A lobby with a reception desk, seating area, and a staircase.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
Rp1.847.614
Rp2.097.041 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
Rp2.124.728
Rp2.411.567 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
Rp2.721.256
Rp3.088.625 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A round marble table with a magazine, a pair of glasses, and a coffee cup.
A living room with a sofa, a coffee table, a hanging light fixture, a framed picture, and a floor lamp.
A cafe with a front desk, a coffee machine, and two chairs outside.
A backyard with a swimming pool, wooden deck, and outdoor furniture.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
Rp3.413.798
Rp3.874.661 total
includes taxes & fees
29 Oct - 30 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.
A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.
A hotel room with two beds, a desk, a chair, and a large window with a view.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
Rp1.991.118
Rp2.259.919 total
includes taxes & fees
2 Nov - 3 Nov
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.
A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.
A modern living room with sofas, a coffee table, and a dining area.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
Rp2.134.622
Rp2.422.796 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott® Jacksonville Mayport
A pathway leading to a sunset over a beach with sand and grass.
A modern building entrance with a sign reading "element by Westin".
A modern conference room with a long table, several chairs, and pendant lighting.
A modern hotel lobby with a long reception desk, seating area, and large windows.

10. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Lisa
Rp2.583.072
Rp2.931.787 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Room
Terrace/patio
Lobby

11. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Camoya
Rp2.166.263
Rp2.458.709 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".
A modern bar area with seating, a bar counter, and a view of the city through large windows.
A modern hotel with a pool, palm trees, and a clear blue sky.

12. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
Rp3.204.637
Rp3.637.263 total
includes taxes & fees
17 Oct - 18 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.
A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.
A modern bar area with a counter, bar stools, and a television screen.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
Rp2.188.436
Rp2.483.875 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.
An outdoor seating area with round tables and blue chairs, shaded by blue umbrellas with a logo, in front of a building with balconies and palm trees.
A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

14. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
Rp2.876.117
Rp3.264.393 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Jacksonville Beach/Oceanfront
A self-service beverage station with a refrigerated display and a coffee machine.
A modern lounge area with seating, tables, and hanging lights.
A snack display in a store with various chips and snacks.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

15. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Josephine
Rp1.963.852
Rp2.228.971 total
includes taxes & fees
1 Nov - 2 Nov
Tru By Hilton Jacksonville St Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.
A patio area with a stone fire pit, outdoor furniture, and a brick floor.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
Rp1.735.502
Rp1.969.794 total
includes taxes & fees
22 Oct - 23 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
An outdoor patio with seating, a fire pit, and string lights.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

17. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
Rp2.277.262
Rp2.584.693 total
includes taxes & fees
25 Oct - 26 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.
A coffee station with two espresso machines and a display of coffee products.
A golf course with a water hazard and a bridge.
A pier extending into the ocean at sunset with birds flying above.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
Rp2.040.942
Rp2.316.468 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express Jacksonville Beach by IHG
A spacious lobby with a reception desk, seating area, and large windows.
A multi-story hotel with a central entrance, large windows, and a well-lit facade.
A bar area with wooden chairs, a round table, and a brick wall.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

19. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Madison
Rp2.109.153
Rp2.351.705 total
includes taxes & fees
29 Oct - 30 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A hotel room with a dining area, two beds, a TV, and a kitchenette.
A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.
A compact kitchen with dark cabinetry, a built-in refrigerator, a dining table with a chair, and a wall-mounted lamp.
Two people near a grill with a plate of food and a bottle.

20. Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
9.2 km from Mayo Clinic Florida
United States
Joe
Rp1.879.815
Rp2.133.591 total
includes taxes & fees
25 Oct - 26 Oct
Candlewood Suites Jacksonville - Mayport by IHG
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
608 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
664 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
375 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,006 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,001 reviews
View

Top Mayo Clinic Florida Hotel Reviews

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

8/10 Good
"."
Shaneen 1-night trip
Posted 4 hours ago
TownePlace Suites by Marriott Jacksonville East
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"The number one thing about our stay was the staff. John checked is in and everyone we interacted with was positive and helpful. They were generous with coffee and towels. When a little maintenance was needed, they were two quick to reply, the problem wasn't significant enough and we needed to rest. A wild party interrupted next door to us and I asked when quiet time started and at that time (10pm) the wild noise stopped. The TV was good, the balcony better, and the exercise room more than adequate. We did not eat on property but service is available. Thank you Margaritaville."
Patrick 4-night trip
Posted 15 hours ago
Margaritaville Jacksonville Beach
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"The Evening/Night staff was exceptional"
William 4-night trip
Posted 16 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.