The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix - 2026 Updated Prices

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Our top choices for Mayo Clinic Scottsdale hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A breakfast buffet area with various pastries and a sign indicating the price of a cheese danish.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Michael

Rp1.928.889

Rp2.198.355 total

includes taxes & fees

20 Oct - 21 Oct

A cluster of modern, multi-story buildings with a river in the foreground.

A dining area with a glass table, wooden chairs, and potted plants.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

A golf course with a pond, a clubhouse, and a hilly backdrop.

2. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Stephanie

Rp2.320.529

Rp2.649.349 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

3. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

LAURA

Rp1.963.140

Rp2.238.372 total

includes taxes & fees

1 Nov - 2 Nov

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

A reception area with marble reception desks, a wooden ceiling, and a wall-mounted refrigerator.

A multi-story hotel with a central courtyard, parking, and a mountainous backdrop.

A spacious living area with a sofa, chairs, a coffee table, and a TV mounted on the wall.

4. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Cassie

Rp2.433.645

Rp2.773.625 total

includes taxes & fees

25 Oct - 26 Oct

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

A hotel room with a sofa, a TV, a desk, and a chair. There are framed pictures on the wall.

5. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Wilson

Rp1.516.972

Rp1.728.892 total

includes taxes & fees

25 Oct - 26 Oct

A wooden door with a glass panel, a doormat, and a small window above it.

A bedroom with a desk, a bed, a ceiling fan, and a window with blinds.

6. Close to Hiking! Family-friendly Mesa Retreat

13.6 km from Mayo Clinic Scottsdale

Rp3.244.860

Rp14.115.141 total

includes taxes & fees

26 Oct - 27 Oct

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

A modern lobby with a seating area, a kitchen, and a reception desk.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

7. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

Rp2.758.131

Rp3.151.716 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

A golf course with a mountain backdrop, surrounded by desert vegetation.

8. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

jennifer

Rp2.097.441

Rp2.930.215 total

includes taxes & fees

19 Oct - 20 Oct

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A modern hotel lobby with a reception desk, marble counter, and a seating area with tables and chairs.

A bar area with a bar counter, multiple chairs, and a sofa.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

9. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

PATRICK

Rp1.844.342

Rp2.101.997 total

includes taxes & fees

26 Oct - 27 Oct

A modern infinity pool with a view of mountains and a sunset.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

An outdoor seating area with fire pits and lounge chairs, surrounded by trees and a building with illuminated windows in the background.

10. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Jessica

Rp3.828.574

Rp4.879.290 total

includes taxes & fees

8 Nov - 9 Nov

A spacious living area with a kitchen, modern furniture, and a fireplace.

A hotel room with a large bed, a dresser with drawers, a wardrobe, and a wall-mounted TV displaying a pool view.

A modern lobby with a pool view, orange seating, and a wooden accent wall.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

11. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

Rp1.964.943

Rp2.243.460 total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A hotel gym with dumbbells on racks, a bench, and a mirror.

A hotel room with a desk, chair, television, lamp, and a framed artwork on the wall.

A hotel breakfast area with a self-serve station, seating, and a trash bin.

12. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

Rp1.892.835

Rp2.157.471 total

includes taxes & fees

26 Oct - 27 Oct

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

A hotel room with two beds, a desk, a sofa, and a TV.

A multi-story hotel with a parking lot and a road leading to a roundabout.

A spacious living area with a sofa, armchairs, and a coffee table. There is a TV mounted on the wall and a balcony with outdoor seating.

13. Hyatt Place Scottsdale - North

14.1 km from Mayo Clinic Scottsdale

Ted

Rp2.992.482

Rp3.410.531 total

includes taxes & fees

25 Oct - 26 Oct

A resort with multiple buildings, a large pool area, and surrounding mountains.

Three people in a swimming pool with rocks and a red umbrella in the background.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

An outdoor wedding reception with round tables set with white chairs, floral centerpieces, and a view of the city in the background.

14. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Garrett

Rp3.877.608

Rp5.147.430 total

includes taxes & fees

21 Oct - 22 Oct

A swimming pool with a water slide, a sun lounger, and a covered seating area.

A Holiday Inn & Suites building with a curved facade, multiple balconies, and a well-lit entrance.

A reception area with a blue counter, a television screen, and a modern interior design.

A breakfast bar with a variety of baked goods and a sign indicating fresh baked items.

15. Holiday Inn & Suites Scottsdale North - Airpark by IHG

9.7 km from Mayo Clinic Scottsdale

Ally Marie

Rp2.794.185

Rp3.184.533 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

A buffet counter with various food items, a refrigerator, and a wall-mounted clock.

16. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale

Susan

Rp2.024.793

Rp2.307.657 total

includes taxes & fees

22 Oct - 23 Oct

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

A hotel room with a bed, a desk with a TV, a sofa, and a coffee table.

An outdoor patio with a grill, table, and chairs.

A breakfast buffet with various food items and a coffee machine.

17. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Denine

Rp2.145.213

Rp2.444.898 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio area with round tables and chairs, a pool in the background, and a covered seating area.

A hotel room with a bed, a desk, a chair, a sofa, a small table, and a TV.

A hotel reception area with a large bridge mural, a reception desk, and a snack bar.

A multi-story hotel with illuminated signage reading "Talking Stick" and "Resort".

18. Staybridge Suites Scottsdale - Talking Stick by IHG

9.7 km from Mayo Clinic Scottsdale

Steve

Rp3.226.833

Rp3.679.235 total

includes taxes & fees

19 Oct - 20 Oct

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A modern lobby with a central water feature, seating area, and a stone pillar.

A Courtyard by Marriott hotel with a modern design, featuring a covered entrance and stone pillars.

A modern bar area with seating, a digital menu display, and a beverage refrigerator.

19. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

Rp2.794.185

Rp3.184.533 total

includes taxes & fees

25 Oct - 26 Oct

An indoor water park with slides, a wave pool, and seating areas.

An indoor adventure park with rope bridges, climbing structures, and a large bear statue.

A modern bar area with a long counter, multiple stools, and a view through large windows.

A lobby with a stone fireplace, wooden beams, and a chandelier.

20. Great Wolf Lodge Arizona

10.2 km from Mayo Clinic Scottsdale

Dejanira

Rp2.865.392

Rp3.353.081 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,085 reviews	View
Inn at Eagle Mountain	9.0 Wonderful 1,031 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 2,053 reviews	View
Hyatt House North Scottsdale	9.6 Exceptional 1,001 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,874 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Aiden by Best Western Scottsdale North

10/10 Excellent

"Great breakfast and served until 10:00 a.m. all days; could sleep in."

Staybridge Suites Scottsdale - Talking Stick by IHG

10/10 Excellent

"Breakfast was better than most with fresh fruit and lots of options."

Holiday Inn & Suites Scottsdale North - Airpark by IHG

10/10 Excellent

"Wonderful personnel, clean environment and easy access to restaurants etc. The only down was the towels were very scratchy. The free Lyft was so convenient and easy to use. I really enjoyed my week."

Comfort Suites Scottsdale Talking Stick Entertainment District

10/10 Excellent

"Property was really relaxing, close to restaurants and shopping centers. Pop stroke being in the parking lot was fun. We'll definitely be going back!"

Sonesta Simply Suites Phoenix Scottsdale

10/10 Excellent

"W"

Tru By Hilton Scottsdale Salt River

10/10 Excellent

"Very clean rooms and the staff very polite and friendly,"

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, take a look at the 22 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodation options within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can use the "fully refundable" filter to get the best deals available near Mayo Clinic Scottsdale.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain or SunRidge Canyon Golf Club are some local sights worth checking out.

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Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Comfort Suites Scottsdale Talking Stick Entertainment District

4. Hyatt House North Scottsdale

5. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

6. Close to Hiking! Family-friendly Mesa Retreat

7. Home2 Suites by Hilton Mesa Longbow, AZ

8. Wekopa Casino Resort

9. Aiden by Best Western Scottsdale North

10. Talking Stick Resort

11. Fountain Park Hotel, BW Signature Collection

12. Holiday Inn Express Scottsdale North by IHG

13. Hyatt Place Scottsdale - North

14. ADERO Scottsdale Resort, Autograph Collection

15. Holiday Inn & Suites Scottsdale North - Airpark by IHG

16. Best Western Plus Scottsdale Thunderbird Suites

17. Sonesta ES Suites Scottsdale Paradise Valley

18. Staybridge Suites Scottsdale - Talking Stick by IHG

19. Courtyard Scottsdale Salt River

20. Great Wolf Lodge Arizona

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Aiden by Best Western Scottsdale North

Staybridge Suites Scottsdale - Talking Stick by IHG

Holiday Inn & Suites Scottsdale North - Airpark by IHG

Comfort Suites Scottsdale Talking Stick Entertainment District

Sonesta Simply Suites Phoenix Scottsdale

Tru By Hilton Scottsdale Salt River

Frequently asked questions

Explore a world of travel with Expedia

Search Hotels Near Mayo Clinic Scottsdale, Phoenix

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Comfort Suites Scottsdale Talking Stick Entertainment District

4. Hyatt House North Scottsdale

5. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

6. Close to Hiking! Family-friendly Mesa Retreat

7. Home2 Suites by Hilton Mesa Longbow, AZ

8. Wekopa Casino Resort

9. Aiden by Best Western Scottsdale North

10. Talking Stick Resort

11. Fountain Park Hotel, BW Signature Collection

12. Holiday Inn Express Scottsdale North by IHG

13. Hyatt Place Scottsdale - North

14. ADERO Scottsdale Resort, Autograph Collection

15. Holiday Inn & Suites Scottsdale North - Airpark by IHG

16. Best Western Plus Scottsdale Thunderbird Suites

17. Sonesta ES Suites Scottsdale Paradise Valley

18. Staybridge Suites Scottsdale - Talking Stick by IHG

19. Courtyard Scottsdale Salt River

20. Great Wolf Lodge Arizona

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Aiden by Best Western Scottsdale North

Staybridge Suites Scottsdale - Talking Stick by IHG

Holiday Inn & Suites Scottsdale North - Airpark by IHG

Comfort Suites Scottsdale Talking Stick Entertainment District

Sonesta Simply Suites Phoenix Scottsdale

Tru By Hilton Scottsdale Salt River

Frequently asked questions

Explore a world of travel with Expedia