Search Hotels in Otay Mesa, San Diego

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
29 Jul - 30 Jul
Tomorrow
30 Jul - 31 Jul
This weekend
1 Aug - 3 Aug
Next weekend
8 Aug - 10 Aug

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Otay Mesa, San Diego

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Welcome to Holiday Inn Express & Suites, featuring a modern design with a lush entrance area and a prominent address sign.

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.8 out of 10, Good, (1402)
"Great stay, close to the Cross Border Xpress "
The price is Rp2.078.228
Rp2.363.984 total
includes taxes & fees
5 Aug - 6 Aug
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Quality Suites San Diego Otay Mesa
Two single beds with green bedspreads, a small armchair, and a bedside table with a lamp are featured in this cozy space.

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1006)
"Great location and spacious room "
The price is Rp1.783.676
Rp2.028.931 total
includes taxes & fees
9 Aug - 10 Aug
Quality Suites San Diego Otay Mesa
Sycuan Casino Resort
Relax by the resort pool surrounded by palm trees and a pebble bed.

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1441)
"We had a wonderful stay, will definitely visit again!"
Sycuan Casino Resort
Days Inn by Wyndham San Diego-East/El Cajon
Relax in this serene space with a large bed, ocean-inspired artwork, and a cozy reading nook by the window.

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1000)
"Cozy bed, very quiet and convenient"
The price is Rp1.752.748
Rp1.931.441 total
includes taxes & fees
3 Aug - 4 Aug
Days Inn by Wyndham San Diego-East/El Cajon
Super 8 by Wyndham El Cajon/San Diego
Welcome to the reception area, where a friendly staff is available to assist with your stay. A staircase leads to additional floors, and a clock keeps perfect time.

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.8 out of 10, Good, (1013)
"Great place "
The price is Rp1.701.856
Rp1.872.042 total
includes taxes & fees
10 Aug - 11 Aug
Super 8 by Wyndham El Cajon/San Diego
Best Western Plus La Mesa San Diego
Relax in the stylish lobby, featuring a reception desk, comfortable seating area, and decorative shelving unit.

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very good, (1000)
"Staff was friendly, hotel was clean and breakfast was great"
The price is Rp1.885.133
Rp2.073.646 total
includes taxes & fees
17 Aug - 18 Aug
Best Western Plus La Mesa San Diego
SpringHill Suites by Marriott Chula Vista Eastlake
Relax by the ocean with a clear view from this pool area, surrounded by lounge chairs and tables under the shade of palm trees.

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (385)
"Clean property and great breakfast!"
The price is Rp2.372.780
Rp2.614.685 total
includes taxes & fees
10 Aug - 11 Aug
SpringHill Suites by Marriott Chula Vista Eastlake
Ayres Hotel San Diego South - Chula Vista
Relax in a comfortable seating area surrounded by lush greenery and a bar.

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1093)
"Very nice hotel"
The price is Rp2.563.257
Rp2.824.590 total
includes taxes & fees
3 Aug - 4 Aug
Ayres Hotel San Diego South - Chula Vista
Heritage Inn La Mesa
Relax by the pool surrounded by a deck with comfortable seating and umbrellas.

Heritage Inn La Mesa

2.0 star property
6.6 out of 10, (1043)
"Familiar stay"
The price is Rp1.251.682
Rp1.380.140 total
includes taxes & fees
31 Jul - 1 Aug
Heritage Inn La Mesa
Lamplighter Inn & Suites at SDSU
Relax by the pool surrounded by lounge chairs and umbrellas, with a lifeguard on duty.

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1224)
"Great place"
Lamplighter Inn & Suites at SDSU
Best Western Chula Vista/Otay Valley Hotel
Relax in a well-appointed room with a comfortable seating area, desk, and coffee station.

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1453)
"Clean, great staff. "
The price is Rp1.938.723
Rp2.132.596 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Chula Vista/Otay Valley Hotel
La Quinta Inn by Wyndham San Diego Chula Vista
Experience the charm of this historic hotel, featuring a striking bell tower and sheltered entrance.

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1325)
"Love the breakfast and convenient location. "
The price is Rp1.988.226
Rp2.187.049 total
includes taxes & fees
11 Aug - 12 Aug
La Quinta Inn by Wyndham San Diego Chula Vista
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Two single beds with geometric-patterned bedding and a dark headboard, set against a backdrop of white and blue walls.

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (1162)
"Nice hotel to stay in "
The price is Rp1.358.048
Rp1.547.360 total
includes taxes & fees
31 Jul - 1 Aug
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Valli Hi Motel
Relax in a spacious room with a large bed, wooden desk, and comfortable seating area.

Valli Hi Motel

2.5 star property
8.2 out of 10, Very good, (1033)
"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."
Valli Hi Motel
Best Western Americana Inn
Two large beds with white linens and wooden headboards, a flat-screen TV, and a desk with a lamp.

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1133)
"The breakfast was very good and the front desk and housekeeping hospitality were great. I would definitely stay here again!"
The price is Rp2.007.149
Rp2.283.132 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Americana Inn
Chula Vista Inn
Stunning hotel entrance with arched design, surrounded by lush greenery and a palm tree.

Chula Vista Inn

2.5 star property
6.6 out of 10, (1015)
"Pleasant quiet and so affordable. I look forward to coming back when their pool and Jacuzzi is fully functioning."
Chula Vista Inn
Quality Inn San Diego South - Chula Vista
Enjoy a perfectly brewed cup at our in-room coffee station, featuring a coffee machine, milk frother, and water dispenser.

Quality Inn San Diego South - Chula Vista

2.5 star property
7.8 out of 10, Good, (1000)
"Good hotel "
The price is Rp1.516.125
Rp1.667.738 total
includes taxes & fees
10 Aug - 11 Aug
Quality Inn San Diego South - Chula Vista
Hotel Palmeras Chula Vista
Guests can park adjacent to the building, with a covered entrance nearby.

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1806)
"It’s was good experience staying in hotel "
The price is Rp1.130.351
Rp1.243.386 total
includes taxes & fees
31 Jul - 1 Aug
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
Relax in a serene space with a large bed, desk, and comfortable seating area.

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1210)
"Great place to stay!"
The price is Rp1.858.168
Rp2.047.608 total
includes taxes & fees
31 Jul - 1 Aug
Hercor Hotel - Urban Boutique
Howard Johnson by Wyndham National City/San Diego South
Contemporary bathroom with sleek countertop, white sink, and large mirror.

Howard Johnson by Wyndham National City/San Diego South

2.0 star property
7.4 out of 10, Good, (1012)
"Great place 👍"
The price is Rp1.456.396
Rp1.604.817 total
includes taxes & fees
31 Jul - 1 Aug
Howard Johnson by Wyndham National City/San Diego South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Belmont Park featuring a park and rides
Mission Beach map

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Gaslamp Quarter featuring a bar, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach map

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa Hotel Reviews

The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"Wonderful place!"
Dawne 4-night trip
Posted 2 days ago
The Dana on Mission Bay

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodation options, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.