Otay Mesa Travel Guide

San Diego


Popular places to visit

Things to do


Top hotels in Otay Mesa

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St, San Diego, CA
The price is Rp2.161.831 per night from 26 Oct to 27 Oct
Rp2.161.831
Rp2.484.917 total
26 Oct - 27 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and a fitness centre. Popular attractions Mission Bay and Mission ...
9/10 Wonderful! (163 reviews)
"This is a nice place. The room was comfortable and clean. The breakfast was good although tables should have been cleaned after guest use. Spillage on floors also should have been addressed. My complaint lies with the location of this establishment. Not really a safe area. A number of police helicopters ..."

Reviewed on 15 Oct 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is Rp3.962.859 per night from 30 Oct to 31 Oct
Rp3.962.859
Rp5.496.767 total
30 Oct - 31 Oct
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 6 restaurants and 3 bars/lounges. Our guests praise the pool and the bar in their ...
9/10 Wonderful! (2,847 reviews)
"Always great! Room and view were beautiful. Only thing was the hallway had bits of trash throughout."

Reviewed on 12 Oct 2025

Manchester Grand Hyatt San Diego
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

3.5 out of 5
San Diego, CA
The price is Rp1.367.103 per night from 28 Oct to 29 Oct
Rp1.367.103
Rp1.544.075 total
28 Oct - 29 Oct
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, a rooftop terrace and parking (surcharge). Our guests praise the helpful staff ...
7.8/10 Good! (1,070 reviews)
"Had an early flight could not get breakfast and did notifier a to go breakfast."

Reviewed on 15 Oct 2025

Comfort Inn San Diego Airport At The Harbor
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the pool and the bar in their ...
8.2/10 Very Good! (2,128 reviews)
"The hotel is very clean, pool and spa are fantastic, the food at the hotel was excellent"

Reviewed on 13 Oct 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is Rp2.522.799 per night from 23 Oct to 24 Oct
Rp2.522.799
Rp3.405.908 total
23 Oct - 24 Oct
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (6,004 reviews)
"Great that there is an airport shuttle. Very convenient to cruise terminal."

Reviewed on 12 Oct 2025

Wyndham San Diego Bayside
Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street, San Diego, CA
The price is Rp4.396.350 per night from 9 Nov to 10 Nov
Rp4.396.350
Rp5.968.821 total
9 Nov - 10 Nov
includes taxes & fees
Stay at this 5-star luxury hotel in San Diego. Enjoy free Wi-Fi, a full-service spa and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,019 reviews)
"The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!"

Reviewed on 15 Oct 2025

Pendry San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

Petco Park showing a statue or sculpture

East Village

Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

East Village
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Mid-City

While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Gaslamp Quarter
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Downtown San Diego

4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Downtown San Diego
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North Park

North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

North Park
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Little Italy

Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Little Italy


Otay Mesa Travel Guide