What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and Drury Inn & Suites San Antonio Northwest Medical Center .

How many hotels will I be able to find in Medical Center District?

Expedia has 124 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Our top choices for Medical Center District hotels

1. Courtyard by Marriott Medical Center San Antonio

Medical Center District

Melissa

Rp1.861.515 total

includes taxes & fees

4 Sept - 5 Sept

2. Park Inn by Radisson, Medical Center

Medical Center District

Amanda

Rp1.375.806 total

includes taxes & fees

30 Aug - 31 Aug

3. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District

Melissa

Rp1.882.223 total

includes taxes & fees

30 Aug - 31 Aug

4. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District

Melissa

Rp1.857.331 total

includes taxes & fees

25 Aug - 26 Aug

5. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Medical Center District

Matthew

Rp1.786.482 total

includes taxes & fees

6 Sept - 7 Sept

6. OYO Inn & Suites Medical Center San Antonio

Medical Center District

Ronnie

Rp1.138.177 total

includes taxes & fees

6 Sept - 7 Sept

7. San Antonio Marriott Northwest Medical Center

Medical Center District

Mario

Rp2.305.460 total

includes taxes & fees

18 Sept - 19 Sept

8. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Medical Center District

Jose

Rp1.122.806 total

includes taxes & fees

25 Aug - 26 Aug

9. Atria Inn & Suites

Medical Center District

Gloria

Rp1.256.610 total

includes taxes & fees

20 Sept - 21 Sept

10. Studio 6 San Antonio, Tx - Northwest Medical Center

Medical Center District

Ruben

Rp968.923 total

includes taxes & fees

25 Aug - 26 Aug

11. Motel 6 San Antonio, TX - Northwest Medical Center

Medical Center District

Rachel

Rp1.054.985 total

includes taxes & fees

30 Aug - 31 Aug

12. Flex Studios

Medical Center District

Jasper

Rp828.269 total

includes taxes & fees

25 Aug - 26 Aug

13. Drury Plaza Hotel San Antonio Airport

9 km from Medical Center District

Alejandra

Rp2.384.203 total

includes taxes & fees

30 Aug - 31 Aug

14. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Uptown, 9.3 km from Medical Center District

Victor M.

Rp1.673.145 total

includes taxes & fees

25 Aug - 26 Aug

15. Hyatt Place San Antonio-Northwest/Medical Center

3.7 km from Medical Center District

Daniel

Rp1.966.766 total

includes taxes & fees

31 Aug - 1 Sept

16. La Quinta Inn & Suites by Wyndham San Antonio Airport

Shearer Hills - Ridgeview, 9.3 km from Medical Center District

Roland

Rp1.656.512 total

includes taxes & fees

30 Aug - 31 Aug

17. Holiday Inn Express San Antonio-Airport by IHG

8.9 km from Medical Center District

Edgar

Rp2.112.506 total

includes taxes & fees

30 Aug - 31 Aug

18. Wyndham Garden San Antonio Airport

Uptown, 9.2 km from Medical Center District

Michelle

Rp1.780.901 total

includes taxes & fees

20 Sept - 21 Sept

19. Drury Plaza Hotel San Antonio North Stone Oak

Stone Oak, 14.8 km from Medical Center District

Olga

Rp2.133.212 total

includes taxes & fees

30 Aug - 31 Aug

20. Crowne Plaza San Antonio Airport by IHG

Uptown, 11.8 km from Medical Center District

Emmanuel

Rp1.568.693 total

includes taxes & fees

27 Aug - 28 Aug

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Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,431 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,056 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,015 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,160 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,611 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A large, abstract sculpture with a flowing design, set against a dramatic sky.

Uptown

If you're spending some time in Uptown, Alamo Quarry Market and San Antonio Zoo and Aquarium are top sights worth seeing.

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A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

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A field of bluebonnets under a vibrant sunset sky.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

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Top Medical Center District Hotel Reviews

Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent

"They staff were friendly and efficient. We were locked out of our room at one point. One of the cleaners paged the one of the managers and took us to the front desk. A manager met us there and were able to open the door for us and, for security purposes, she check our ID with the room. She resolved our problem and maintained security measures. Also their breakfast varieties were excellent. My only recommendations were to extend the time for the swimming pool from 10pm to 11pm. That would be great."